The Accuracy of an Intraoperative Frozen Section for Premalignant Endometrial Pathology

Abstract

<p><strong>OBJECTIVE</strong>: Abnormal uterine bleeding which is the most frequent complaint among pre- and postmenopausal women should be investigated to rule out endometrial cancer. An intra-operative frozen section can be taken to examine the suspicious of the malignancy. The study aims to investigate the accuracy of frozen section in suspicious of endometrial malignancy.</p><p><strong>STUDY DESIGN:</strong> Fifty patients with pre-malign endometrial pathology and malignant ultrasound characteristics were included in this study and their preoperative biopsy, frozen and postoperative pathological results were examined. </p><p><strong>RESULTS:</strong> The kappa coefficient between postoperative pathology and frozen section was 0.88 (p<0.05) and 95% confidence interval was (0.63-1.12). This indicates that the amount of agreement between the two tests was strong, thus the frozen section would be considered as a valid indicator of postoperative pathology results.</p><p><strong>CONCLUSIONS:</strong> Frozen section is a valuable method to investigate the suspicious of malignancy in endometrial pre-malign lesions.</p>