Utility of diffusion-weighted magnetic resonance imaging for liver fibrosis in chronic active hepatitis

Soylu, Aliye; Kılıçkesmez, Özgür; Poturoğlu, Şule; Dolapcioglu, Can; Serez, Kemal; Sevindir, İsa; Yaşar, Nurgül; Akyıldız, Murat; Kumbasar, Abdülbaki

doi:10.4261/1305-3825.dir.2810-09.1

Cited by 15 publications

(13 citation statements)

References 45 publications

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“…To our knowledge, only three studies have examined how HAI scores changed with ADC values. In two of these studies, Soylu et al [28] and Boulanger et al [30] did not find statistically significant relationships between ADC values and HAI scores. Koinuma et al [29], on the other hand, did find a statistically significant relationship between ADC values and HAI scores although this relationship was not as strong as the relationship between ADC values and fibrosis scores.…”

Section: Discussionmentioning

confidence: 96%

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Utility of diffusion-weighted imaging in the evaluation of liver fibrosis

et al. 2011

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Section: Discussionmentioning

confidence: 96%

“…Several previous studies have found that the ADC values of the liver are lower in patients with cirrhotic liver compared with control subjects [21][22][23][24][25][26][27][28][29][30]. However, there is very limited research on the utility of DWI in the staging of fibrosis [25][26][27]30].…”

Section: Introductionmentioning

confidence: 93%

Utility of diffusion-weighted imaging in the evaluation of liver fibrosis

et al. 2011

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“…In accordance to the recent studies, our initial part of the current study confirmed that liver ADC is significantly reduced in chronic liver disease patients compared with normal subjects. 6,[17][18][19][20][21][22] This can be attributed to the presence of fibrous tissue, which are collagenous tissue associated with restricted diffusion and subsequent diminished ADC values. However, we also found that spleen ADC is significantly increased in patients with chronic liver disease correlating to their splanchnic hyperaemia.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Utility of Adc Value of the Spleen in Assessing Severity of Portal Hypertension in Cirrhosis

Subbiah¹,

Ayyamperumal²,

Chellathurai³

et al. 2018

jemds

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BACKGROUND ADC (Apparent diffusion coefficient) value of the diffusion weighted imaging is a measure of the haemodynamics of the organ. Portal hypertension (PH) is one of the essential manifestations of chronic liver disease. ADC was used in previous studies to indirectly assess fibrosis of the liver. However, no studies have evaluated the ADC value of the spleen to assess the PH features in cirrhosis. Aims and Objectives-We did the study to analyse the correlation of ADC value of the spleen in cirrhotic patients, to the severity of PH in the form of clinically significant PH (CSPH) and also the surrogate markers of PH. MATERIALS AND METHODS We prospectively evaluated patients with chronic liver disease in our hospital from the month of June 2017 to October 2017 with MRI of the abdomen. 1.5-tesla diffusion-weighted imaging with ADC mapping was performed with b value of 0, 300 and 500 and the ADC value of the spleen and liver were calculated. They were correlated with the severity of the PH in terms of CSPH and PH surrogate markers. RESULTS In chronic liver disease/ cirrhotic patients, we found a significant correlation between ADC value of the spleen and CSPH as well as PH surrogate markers in the form of grade of oesophageal varices and symptomatic hypersplenism. CONCLUSION Our study showed that ADC value of the spleen correlated well with the severity of PH. ADC measurements may allow for noninvasive evaluation of portal pressure and even in assessment of treatment response.

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“…However, Boulanger et al used DWI at b values of 50–250 s/mm 2 to examine 18 hepatitis C virus patients and 10 control subjects and found no significant correlation between the ADC values and the inflammation or fibrosis scores [8]. Similarly, Soylu et al calculated the ADC values using measurements from four segments of liver lobes at b values of 0, 500 and 1,000 s/mm 2 and did not find any correlation between the ADC values and liver fibrosis scores at the b 500 and b 1,000 diffusion gradients [17]. In our study, we used b 100, b 600 and b 1,000 gradients representing low, intermediate and high level diffusion gradients, respectively, in order to determine which gradient would be most effective in obtaining a correlation between ADC values and histopathological scores of CVH.…”

Section: Discussionmentioning

confidence: 99%

Diffusion weighted MRI in chronic viral hepatitis: correlation between ADC values and histopathological scores

et al. 2013

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ObjectiveTo investigate the utility of apparent diffusion coefficient (ADC) measurement in the diagnosis of chronic viral hepatitis (CVH) and correlation between ADC values and histopathologic severity of CVH.Materials and methodsThe ADC values of liver parenchyma on diffusion-weighted magnetic resonance imaging (DWMRI) were measured in 50 patients with a history of CVH and 51 healthy subjects at b 100, b 600 and b 1,000 gradients. Comparison between mean ADC values of the CVH and control groups and correlation results between ADC values and necroinflammation and fibrosis scores in CVH were obtained.ResultsMean ADC values of CVH patients were significantly lower than mean ADC values of the control group at b 100 and b 600 gradients (P < 0.05). There was no significant difference between the CVH and control groups at the b 1,000 gradient (P > 0.05). No significant correlation was found between ADC values and histopathologic scores of CVH (P > 0.05).ConclusionADC values obtained at the b 100 and b 600 gradients can be used to distinguish between the liver parenchyma of CVH and healthy subjects. ADC measurement was not found to be useful for estimation of the degree of necroinflammation and fibrosis in CVH.Teaching Points• In chronic viral hepatitis apparent coefficient values are decreased in the liver• There is no correlation between ADC values and histopathologic severity of CVH• DW images obtained at low b values have more ability to demonstrate an ADC decrease in viral hepatitis

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Utility of diffusion-weighted magnetic resonance imaging for liver fibrosis in chronic active hepatitis

Cited by 15 publications

References 45 publications

Utility of diffusion-weighted imaging in the evaluation of liver fibrosis

Utility of diffusion-weighted imaging in the evaluation of liver fibrosis

Diagnostic Utility of Adc Value of the Spleen in Assessing Severity of Portal Hypertension in Cirrhosis

Diffusion weighted MRI in chronic viral hepatitis: correlation between ADC values and histopathological scores

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