Utility of Certain π-Acceptors for the Spectrophotometric Determination of Isoniazid

Hassan, Hoda Y.; Mohamed, Abdel-Maboud I.; Mohamed, Fardous A.

doi:10.1080/00032719008052469

Cited by 13 publications

(2 citation statements)

References 15 publications

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“…Thus, isoniazid because of its activated amino pyridine skeleton, has been used as coupling agents with diazotized reagents such as dapsone and 1-amino anthraquinone zinc chloride 18,19 ; in Schiff base formation with cis-cinnamaldehyde 20 , 4-dimethylaminocinnamaldehyde 21 and as substrate for nucleophilic substitution reactions with epichlorohydrine and 4-hydroxyphenaylchloride 22 . The donor capability of the drug has also been employed in charge-transfer complexation with various acceptors including chloranil, bromanil 23 etc. and condensation reactions with 6,7-dichloroquinoline-5,8-dione, sodium 1,2-naphthoquinone-4-sulphonate 24,25 etc.…”

Section: Introductionmentioning

confidence: 99%

Two new spectrophotometric methods for the determination of isoniazid in bulk form and tablet dosage form

Adegoke¹,

Thomas²,

Babatunde³

et al. 2019

actapharm

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To develop two new spectrophotometric methods for the analysis of isoniazid in bulk form and tablets. The methods involved condensation of isoniazid with salicylaldehyde and diazo coupling with diazotized p-nitroaniline. Critical factors were optimised; evidence for new product formation, selection of analytical wavelengths, temperature and time and solvent for dilution. Validation was carried out according to ICH guidelines. The new methods were used for isoniazid tablets. Isoniazid formed an imine and azo adduct readily with the two reagents at 30 ⁰C after 5 and 20 mins, and determined at 405 and 420 nm, respectively. Low LODs were obtained for the two methods and recoveries were generally above 98%. The methods were successfully adopted for the assay of isoniazid in tablets and there were no significant differences in the contents when compared with the official titrimetric method of analysis. The methods could find application as in-process method in pharmaceutical industries.

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Section: Introductionmentioning

confidence: 99%

Two new spectrophotometric methods for the determination of isoniazid in bulk form and tablet dosage form

Adegoke¹,

Thomas²,

Babatunde³

et al. 2019

actapharm

View full text Add to dashboard Cite

show abstract

“…Several spectrophotometric procedures for the assay of INH employ sodium 1,2-naphthoquinone-4-sulphonate and cetyltrimethyl ammonium bromide [1]; vanadophosphoric acid [2]; 2,5-diphenyl-3-thiazolyltetrazolium chloride [3]; ohydroxyquinolphthalein-Pd (II)-hexadecyl trimethyl ammonium chloride complex [4]; 6,7-dichloroquinoline-5,8-dione [5]; 1-fluoro-2,4-dinitrobenzene [6]; pbenzoquinone [7]; chloranil or bromanil [8]; Fe(II) and 2,2-dipyridyl [9]; tetrazolium blue chloride [10]; ethyl 8-quinolyloxyacetate [11]; and N-bromosuccinimide with celestine blue [12]. The reported analytical procedures for the estimation of RTH in bulk samples and in unit dosage forms are reviewed in a recent work on the spectrophotometric determination of RTH [13].…”

Section: Introductionmentioning

confidence: 99%

Simple Sensitive Spectrophotometric Determination of Isoniazid and Ritodrine Hydrochloride

Naidu¹,

Kanchi²,

Kumar³

et al. 2005

J Anal Chem

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A novel coupling reagent was used for simple, rapid, and sensitive spectrophotometric determination of isoniazid (1NH) and ritodrine hydrochloride (RTH) in pure form or in pharmaceutical preparations of it. The method is based on the diazotization of 4,4-methylene-bism -nitroaniline followed by a coupling reaction with either INH or RTH in hydrochloric acid medium. The resulting colored products have absorption maxima at 495 and 473 nm, respectively. Beer's law is obeyed in the concentration ranges of 0.1-15 µ g/mL and 0.1 − 17 µ g/mL. The method is applied for the analysis of INH/RTH in pharmaceutical preparations and the results agree favorably with the official and reported data. Common excipients used as additives in pharmaceuticals do not interfere in the proposed method. The method offers the advantages of simplicity, rapidity, and sensitivity without the need of extraction or heating.

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Electrochemical oxidation of isoniazid catalyzed by (FcM)TMA at the platinum electrode and its practical analytical application

et al. 2006

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The electrocatalytic oxidation of isoniazid (INH) by (ferrocenylmethyl)trimethylammonium [(FcM)TMA] at the platinum electrode in 0.10 M Na2SO4 aqueous solution was studied by cyclic voltammetry (CV). Although INH itself showed a very poor electrochemical response at the platinum electrode, the response could be greatly enhanced by using (FcM)TMA as a mediator, which enables a sensitive electrochemical determination of the substrate INH. The reaction rate constant for catalytic oxidation reaction was evaluated as (3.98+/-0.10)x10(3) M(-1) s(-1) by using chronoamperometry (CA). Experimental conditions such as supporting electrolyte and its concentration, solution pH, and the concentrations of the catalyst (FcM)TMA and the substrate INH were investigated to maximize the current efficiency of the electrocatalytic oxidation. The method can be used for the sensitive practical determination of INH, and also opens an avenue for using (FcM)TMA as a mediator in electroanalytical determination which is very simple, cheap, and rapid. Furthermore, no sample pretreatment or time-consuming extraction steps are required prior to the analysis.

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Utility of Certain π-Acceptors for the Spectrophotometric Determination of Isoniazid

Cited by 13 publications

References 15 publications

Two new spectrophotometric methods for the determination of isoniazid in bulk form and tablet dosage form

Two new spectrophotometric methods for the determination of isoniazid in bulk form and tablet dosage form

Simple Sensitive Spectrophotometric Determination of Isoniazid and Ritodrine Hydrochloride

Electrochemical oxidation of isoniazid catalyzed by (FcM)TMA at the platinum electrode and its practical analytical application

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