Electrochemical oxidation of isoniazid catalyzed by (FcM)TMA at the platinum electrode and its practical analytical application

Abstract

The electrocatalytic oxidation of isoniazid (INH) by (ferrocenylmethyl)trimethylammonium [(FcM)TMA] at the platinum electrode in 0.10 M Na2SO4 aqueous solution was studied by cyclic voltammetry (CV). Although INH itself showed a very poor electrochemical response at the platinum electrode, the response could be greatly enhanced by using (FcM)TMA as a mediator, which enables a sensitive electrochemical determination of the substrate INH. The reaction rate constant for catalytic oxidation reaction was evaluated as (3.98+/-0.10)x10(3) M(-1) s(-1) by using chronoamperometry (CA). Experimental conditions such as supporting electrolyte and its concentration, solution pH, and the concentrations of the catalyst (FcM)TMA and the substrate INH were investigated to maximize the current efficiency of the electrocatalytic oxidation. The method can be used for the sensitive practical determination of INH, and also opens an avenue for using (FcM)TMA as a mediator in electroanalytical determination which is very simple, cheap, and rapid. Furthermore, no sample pretreatment or time-consuming extraction steps are required prior to the analysis.

Electrochemical sensor for Isoniazid based on the glassy carbon electrode modified with reduced graphene oxide–Au nanomaterials

“…Larger faradic currents were obtained at RGO-Au/GCE electrode, indicating that the RGO-Au/GCE electrode has more favorable electron transfer kinetics than GCE, Au/GCE, and RGO/GCE electrode. In previous reports, INZ was oxidized at (FcM)TMA/Pt electrode in neutral media at 0.6 V vs. SCE [51], the PASA electrode in PBS (pH 6.5) at 0.55 V vs. SCE [27] and the OMC/GCE electrode in PBS ( pH 7.0) at 0.20 V vs. Ag/AgCl [26]. From Fig.…”

Selective determination of isoniazid using bentonite clay modified electrodes

“…From the slope of I C /I vs. t 1/2 plot (supporting information Fig. S3), k C was estimated to be 2.3 × 10 3 M -1 s -1 which is comparable to reported value [36] for (FcM)TMA catalyst at platinum electrode and indicate the efficient electrocatalytic oxidation. Chronoamperometry experiments are performed at different concentrations of IZ at GC/Na + -bt/Fe(dmbpy) 3 2+ electrode to determine the diffusion coefficient (D) of IZ and Cottrell equation is employed for the determination [34] (equation 2).…”

Silver Hexacyanoferrate (III) on a Hybrid Graphene Oxide/PAMAM Dendrimer Surface and Application as an Electrocatalyst in the Detection of Isoniazid

“…The Fe III produced during the anodic scan chemically oxidizes isoniazid, while Fe III is reduced to Fe II , which will then be electrochemically oxidized to Fe III . The electrochemical (ES) and chemical (CS) steps that occur are represented by Equations 3 and 4, respectively . …”