Electrochemical sensor for Isoniazid based on the glassy carbon electrode modified with reduced graphene oxide–Au nanomaterials

Guo, Zhuo; Wang, Zeyu; Wang, Huihua; Huang, Guoqing; Li, Mengmeng

doi:10.1016/j.msec.2015.07.045

Cited by 48 publications

(22 citation statements)

References 55 publications

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“…The band at 1052 cm −1 belongs to the C-O (alkoxy), while the band at 1633 cm −1 derives from the vibration of the adsorbed water molecules and/or the contribution of the skeletal vibration of unoxidized graphitic domains. After the reduction, the peaks at 1070 cm −1 assigned to epoxy groups are decreased significantly, clearly indicating the removal of oxygen-containing groups of GO (curve b in Figure 2 ) and suggesting the successful reduction of GO [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

Highly Sensitive Amperometricα-Ketoglutarate Biosensor Based on Reduced Graphene Oxide-Gold Nanocomposites

Peng

Chen

et al. 2020

International Journal of Analytical Chemistry

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Herein, a rapid and highly sensitive amperometric biosensor for the detection of α-ketoglutarate (α-KG) was constructed via an electrochemical approach, in which the glutamate dehydrogenase (GLUD) was modified on the surface of reduced graphene oxide-gold nanoparticle composite (rGO-Aunano composite). The rGO-Aunano composite was one-step electrodeposited onto glassy carbon electrode (GCE) surface and was characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and electrochemical techniques. In addition, the rGO-Aunano/GCE was also found to electrocatalyze the oxidation of β-nicotinamide adenine dinucleotide (NADH) at the peak potential of 0.3 V, which was negatively shifted compared with that at bare GCE or Aunano/GCE, illustrating better catalytic performance of rGO-Aunano. After the modification of GLUD, the GLUD/rGO-Aunano/GCE led to effective amperometric detection of α-KG through monitoring the NADH consumption and displayed a linear response in the range of 66.7 and 494.5 μM, with the detection limit of 9.2 μM. Moreover, the prepared GLUD/rGO-Aunano/GCE was further evaluated to be highly selective and used to test α-KG in human serum samples. The recovery and the RSD values were calculated in the range of 97.9–102.4% and 3.8–4.5%, respectively, showing a great prospect for its real application.

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Section: Resultsmentioning

confidence: 99%

Highly Sensitive Amperometricα-Ketoglutarate Biosensor Based on Reduced Graphene Oxide-Gold Nanocomposites

Peng

Chen

et al. 2020

International Journal of Analytical Chemistry

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“…Of course, it is often combined with other anti-tuberculosis agents to resist the mycobacterium strains. It is undeniable that isoniazid is an indispensable essential medicine for treating tuberculosis in medicine [4][5][6][7]. Unfortunately, even in excellent effects on treatment of tuberculosis, there has not avoid to cause pains from a number of side effects, toxicity such as hepatotoxicity and multiple drug resistances, sometimes it can even cause death [8,9].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Application of Keggin Silicomolybdic acid Modified Electrode

M¹,

Li²

2020

Preprint

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An innovative method for the determination of isoniazid tablets is studied through electrochemical method for the modification of glassy carbon electrode (GCE). Polyoxomolybdate, with stable structures, has not been widely used for the determination of substance. In this study, the mentioned polyoxomolybdate was characterized by Fourier transform infrared spectroscopy (FT-IR), UV-vis, X-ray diffraction (XRD), Atomic force microscope (AFM) and X-ray photoelectron spectroscopy (XPS), and used to modify the glassy carbon electrode. The electrochemical performance of the polyoxomolybdate@GCE was investigated with cyclic voltammetry (CV) and differential pulse voltammetry (DPV), compared with the unmodified electrode, the proposed polyoxomolybdate modified electrode exhibited strong electro-catalytic activities towards isoniazid (INH). Under the optimized conditions, there was linear relationships between the DPV peak currents and the concentrations in the range of 1 × 10 -7 g/L to 3 × 10 -7 g/L for INH (R 2 = 0.9979), with the limit of detection (LOD) of 0.024 μg/L (based on S/N = 3). The modified electrode has proper reproducibility (RSD < 5%), stability, response time (< 3 min) and lifetime (up to 6 days).

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“…Graphenes are 2-D structures, providing large surface area, zero band gap, extremely high intrinsic charge carrier mobility and high chemical stability [ 20 , 21 , 22 , 23 , 24 , 25 ]. Many researchers have studied the physical characteristics of graphene [ 26 , 27 ]. Graphene was used to modify the ion sensors, with significant improvement of the sensing characteristics.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Sensitivities and Drift Effects of the Arrayed Flexible Chloride Sensor Based on RuO2/GO at Different Temperatures

Tseng

Chou

et al. 2018

Sensors

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We investigate the temperature effect on sensing characteristics and drift effect of an arrayed flexible ruthenium dioxide (RuO2)/graphene oxide (GO) chloride sensor at different solution temperatures between 10 °C and 50 °C. The average sensor sensitivities according to our experimental results were 28.2 ± 1.4 mV/pCl (10 °C), 42.5 ± 2.0 mV/pCl (20 °C), 47.1 ± 1.8 mV/pCl (30 °C), 54.1 ± 2.01 mV/pCl (40 °C) and 46.6 ± 2.1 mV/pCl (50 °C). We found the drift effects of an arrayed flexible RuO2/GO chloride sensor in a 1 M NaCl solution to be between 8.2 mV/h and 2.5 mV/h with solution temperatures from 10 °C to 50 °C.

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Electrochemical sensor for Isoniazid based on the glassy carbon electrode modified with reduced graphene oxide–Au nanomaterials

Cited by 48 publications

References 55 publications

Highly Sensitive Amperometricα-Ketoglutarate Biosensor Based on Reduced Graphene Oxide-Gold Nanocomposites

Highly Sensitive Amperometricα-Ketoglutarate Biosensor Based on Reduced Graphene Oxide-Gold Nanocomposites

Preparation and Application of Keggin Silicomolybdic acid Modified Electrode

Investigation of Sensitivities and Drift Effects of the Arrayed Flexible Chloride Sensor Based on RuO2/GO at Different Temperatures

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