Utility of base deficit, lactic acid, microalbuminuria, and C-reactive protein in the early detection of complications in the immediate postoperative evolution

Fast-track Surgery Improves Postoperative Recovery in Patients with Gastric Cancer: A Randomized Comparison with Conventional Postoperative Care

“…37 Several cytokines such as IL-6, TNF-α, and CRP have been demonstrated to be involved in the response to surgical stress and are therefore useful serum markers for evaluating the severity of surgery-induced stress. [21][22][23][24] The postoperative profile of IL-6, TNF-α and CRP in patients with GC supported the notion that FTS generated significantly less stress in patients. Surgical trauma causes marked metabolic changes, and REE also acts as the marker for surgical stress.…”

“…[15][16][17][18] It has been established that a higher rate of serious postoperative complications is associated with an excessive response to surgical stress, 2,19,20 and that C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor-α (TNF-α), and resting energy expenditure (REE) may act as markers for the severity of the surgical stress response. [21][22][23][24][25][26] FTS is based on the reduction of surgical stress by various surgical and anesthetic approaches to aid faster recovery. Reports on fast-track rehabilitation in GC are very rare, and the feasibility and safety of fast-track rehabilitation programs in patients with GC requires further evaluation.…”

Diagnostic value of C-reactive protein to rule out infectious complications after major abdominal surgery: a systematic review and meta-analysis

“…Inclusion criteria were not met in 30 studies. Most of the excluded studies either had a retrospective design or assessed the value of CRP in settings other than major abdominal surgery [3, 10, 14, 17–19, 21, 28–38]. The remaining 22 studies were included for qualitative analysis of which 16 studies could also be used for meta-analysis (Fig.…”

“…CRP levels are known to increase in the postoperative period, because of surgical tissue damage. CRP levels tend to normalize rapidly in patients with an uncomplicated postoperative course due to its short plasma half-life of 19 h [10, 11]. …”

Role of C-Reactive Protein Assessment as Early Predictor of Surgical Site Infections Development after Pancreaticoduodenectomy

“…C-reactive protein (CRP) and white blood cells (WBCs) are extensively used as inflammatory markers in clinical practice, while their levels in the early postoperative period are strongly influenced by the physiologic stress response; this is the reason why inference regarding their values and SSI development is not obvious. In recent years, different authors have started to investigate the predictive role on postoperative morbidity of different laboratory assays, including serum albumin, aminotransferase and blood urea nitrogen [20], retrospectively considering large surgical series and often including pancreatic resections in their study population [21]. The primary outcomes varied, as they alternatively highlighted overall morbidity, global inflammatory complications [22,23] or, more selectively, POPF development [11,24]; furthermore, some authors proposed a series containing a combination of different surgical procedures [22], thus weakening the predictive power on complications development.…”