Utility of B-type natriuretic peptide in predicting postoperative complications and outcomes in patients undergoing heart surgery

Abstract

Preoperative BNP levels >385 pg/ml predict the postoperative complications and one-year mortality after heart surgery. Postoperatively, elevated peak BNP levels and elevated change to peak BNP levels were associated with prolonged hospital stay and mortality within one year.

The Relationship between the Changes of Blood NT-proBNP Levels and Postoperative Atrial Fibrillation Occurance in Coronary Artery By-Pass Grafting Surgery Patients

“…Recently in some studies, it has been put forth that perioperative NT-proBNP levels correlate with complications such as; inotropic agency, intra aortic oballoon pump use, length of hospitalization, postoperative AF and mortality [12] [28].…”

“…BNP enables diuresis and vasodilatation, inhibiting the hypertrophy of vascular smooth muscles and cardiac muscle by renin aldosterone production. It has been shown that natriuretic hormones help determine ventricle dysfunction and predict the complications occuring in the early postoperative period [12] [13]. ANP inhibits the collagen synthesis in fibroblasts and the hypertrophy in myocytes [14].…”

Amino Terminal Pro-B-Type Natriuretic Peptide and Late Left Ventricular Reverse Remodeling in Coronary Artery Bypass Grafting Patients with Low Ejection Fraction

“…31 Si mi larly, nu me ro us stu di es we re pub lis hed re por ting a cor re la ti on bet we en BNP levels and LV func ti on or out co me fol lo wing CABG. 4,8,10,18,22, The ef fects of co ro nary bypass on ven tric le di a me ters and sha pe ha ve not be en well-do cu men ted with lar ge stu di es. Sur gi cal Treat ment for Isc he mic He art Fa i lu re (STICH) in ves tiga tors re por ted 6% re duc ti on in left ven tri cu lar end systo lic vo lu me in dex at the fo urth pos to pe ra ti ve month fol lo wing CABG in pa ti ents with isc he mic car di om yo pathy.…”

“…[1][2][3][4][5][6][7][8][9][10] In the set ting of vo lu me ex pan si on or pres su re over lo ad, in cre a sing wall stress sti mu la tes synthesis of pre -p roBNP in the ven tri cu lar myo car di um. The re le a se of BNP re sults in furt her myo car di al re la xa ti on and exerts an im por tant re gu la tory ro le in res pon se to an acu te in cre a se in ven tri cu lar vo lu me by op po sing the va so cons tric ti on, so di um reten ti on, and an ti di u re tic ef fects of the ac ti va ted re nin-an gi o ten sin-al dos te ro ne system.…”

Comparative Assessment of the Preventive Use of Intra-Aortic Baloon Counterpulsation and Levosimendan in Patients with Coronary Heart Disease and Low Left Ventricular Ejection Fraction

“…Пред и послеопераци онная концентрация BNP является предиктором по требности в инотропных агентах, продленного пребыва ния в реанимации и высокой госпитальной летальности [25]. Риск интраоперационной дисфункции сердца по вышен у больных с концентрацией натрийуретического пептида В типа более 50 пг/мл.…”