Utilisation and expenditure on glucose-lowering drugs used for the treatment of type 2 diabetes mellitus in Ireland, a repeated cross-sectional study

Smith, Amelia; Kennedy, Carmel; Clarke, Sarah; Barry, Michael

doi:10.1016/j.deman.2021.100038

Cited by 2 publications

(1 citation statement)

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“…Therefore, blocking the enzymes α-amylase and α-glucosidase can inhibit the digestion of carbohydrates, delay glucose absorption, and subsequently lower blood sugar levels [13]. This plays a crucial role in the treatment of type 2 diabetes [14]. Figure 4 a and b showed that the leave extracts of Mentha spicata from three different regions have high effectiveness towards both α-amylase and α-glucosidase enzymes.…”

Section: α-Amylase and α-Glucosidase Inhibitory Activitymentioning

confidence: 99%

Total phenolic and flavonoid contents of Mentha spicata leaves aqueous extracts in different regions of Algeria and their antioxidant, and antidiabetic activities

Kaddour¹,

Amara²,

Moussaoui³

et al. 2022

Trop. J. Pharm Res

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Purpose: To evaluate the total phenolic and flavonoid contents of Mentha spicata (MS) leaves aqueous extracts obtained from different regions (El-Oued, Tebessa and El-Tarf) of Algeria, as well as their in vitro antioxidant and antidiabetic activities. Methods: Aqueous extracts were obtained from the air-dried leaves of MS by maceration followed by filtration and evaporation using a rotary evaporator. Folin-Ciocalteu and Aluminium chloride colorimetric techniques were used to determine the total phenolic and flavonoid contents, respectively. The radical DPPH, ABTS, and FRAP tests were used to determine their antioxidant activities, while the in vitro inhibition percentages of α-amylase and α-glucosidase enzymes were used to assess the anti-diabetic activity. Results: The El-Oued's extract exhibited the highest total phenolic content (108.94 mg GAE/g dry extract (DE)), while the highest total flavonoid content (0.039 mg QE/g DE) was found in El-Tarf's extract. The radical DPPH and FRAP scavenging activity of the El-Oued extract exhibited the highest inhibition activities (IC50 = 102.5 and 289.5 μg/mL), respectively, while the ABTS inhibition activity of the El-Tarf extract exhibited a maximum IC50 value of 111 ± 2.8 μg/mL. The MS extract of the El-Oued region had the highest α-amylase and α-glucosidase enzyme activities with IC50 values of 121.4 and 216.9 μg/mL, respectively. Conclusion: The leaves of Mentha spicata exhibit high phenolic and flavonoid contents, along with significant antioxidant and antidiabetic properties. This study reveals that Mentha spicata flavonoid and phenolic contents as well as other properties vary by region.

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Section: α-Amylase and α-Glucosidase Inhibitory Activitymentioning

confidence: 99%