Utilidad de los fitoestrógenos en la reducción de la presión arterial. Revisión sistemática y metaanálisis

Arenas, Malagón; Arenas, Esteban Rosero; Armiñana, M. Amparo Portaceli; García, Miguel Ángel

doi:10.1157/13118060

Cited by 6 publications

(1 citation statement)

References 62 publications

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“…Several meta-analyses of the epidemiological and clinical trials conducted in Asian and Western populations published thus far have shown that the dietary intake of soy isoflavones lowers blood pressure sufficiently in hypertensive and pre-hypertensive subjects [ 46 , 47 , 48 , 49 , 50 ] to the point that they can lower overall cardiovascular risk [ 51 ]. Table 1 summarizes the main findings of the most recently published systematic reviews and meta-analyses on the anti-hypertensive effects of dietary intake of isoflavones.…”

Section: Introductionmentioning

confidence: 99%

The Vascular Effects of Isolated Isoflavones—A Focus on the Determinants of Blood Pressure Regulation

Silva

2021

Biology

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Isoflavones are phytoestrogen compounds with important biological activities, including improvement of cardiovascular health. This activity is most evident in populations with a high isoflavone dietary intake, essentially from soybean-based products. The major isoflavones known to display the most important cardiovascular effects are genistein, daidzein, glycitein, formononetin, and biochanin A, although the closely related metabolite equol is also relevant. Most clinical studies have been focused on the impact of dietary intake or supplementation with mixtures of compounds, with only a few addressing the effect of isolated compounds. This paper reviews the main actions of isolated isoflavones on the vasculature, with particular focus given to their effect on the determinants of blood pressure regulation. Isoflavones exert vasorelaxation due to a multitude of pathways in different vascular beds. They can act in the endothelium to potentiate the release of NO and endothelium-derived hyperpolarization factors. In the vascular smooth muscle, isoflavones modulate calcium and potassium channels, leading to hyperpolarization and relaxation. Some of these effects are influenced by the binding of isoflavones to estrogen receptors and to the inhibition of specific kinase enzymes. The vasorelaxation effects of isoflavones are mostly obtained with plasma concentrations in the micromolar range, which are only attained through supplementation. This paper highlights isolated isoflavones as potentially suitable alternatives to soy-based foodstuffs and supplements and which could enlarge the current therapeutic arsenal. Nonetheless, more studies are needed to better establish their safety profile and elect the most useful applications.

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Section: Introductionmentioning

confidence: 99%

The Vascular Effects of Isolated Isoflavones—A Focus on the Determinants of Blood Pressure Regulation

Silva

2021

Biology

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The association between urinary phytoestrogen excretion and components of the metabolic syndrome in NHANES

et al. 2013

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Estrogenic and anti-neutrophilic inflammatory phenanthrenes from Juncus effusus L.

Tsai

Chuang

et al. 2021

Natural Product Research

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Utilidad de los fitoestrógenos en la reducción de la presión arterial. Revisión sistemática y metaanálisis

Abstract: There are no statistically significant or clinically important differences in blood pressure between patients treated with phyto-oestrogens and those not treated.

Cited by 6 publications

References 62 publications

The Vascular Effects of Isolated Isoflavones—A Focus on the Determinants of Blood Pressure Regulation

The Vascular Effects of Isolated Isoflavones—A Focus on the Determinants of Blood Pressure Regulation

The association between urinary phytoestrogen excretion and components of the metabolic syndrome in NHANES

Estrogenic and anti-neutrophilic inflammatory phenanthrenes from Juncus effusus L.

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