Estrogenic and anti-neutrophilic inflammatory phenanthrenes from <i>Juncus effusus</i> L.

Hu, Haisheng; Tsai, Yi‐Hong; Chuang, Yu Che; Lai, Kuei Hung; Hsu, Yu Ming; Hwang, Tsong Long; Lin, Chao-Cheng; Fülöp, Ferenc; Wu, Yang Chang; Yu, Szu Yin; Kuo, Yi Chun; Chang, Fang Rong

doi:10.1080/14786419.2021.1954644

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…A recent study has reported that phenanthrenes, compounds isolated from J . effuses , can significantly inhibit superoxide anion generation and elastase release in a fMLP/CB-induced human neutrophilic inflammation model [ 57 ]. Despite the concern that ethanol can potentially increase the risk of oral cancer, many mouthwashes contain more than 80% ethanol, which is not crucial for preventing and reducing gingivitis caused by dental plaque [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Protective Effects of Juncus effusus L. Water Extract on Oral Keratinocytes

Wada

Murakami

Ishikawa

et al. 2022

BioMed Research International

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Periodontitis is a chronic inflammatory disease caused by periodontopathogenic bacteria that form biofilms in periodontal pockets. The gingival epithelium acts as the first physical barrier in fighting attacks by periodontopathogenic pathogens, such as the primary etiological agent Porphyromonas gingivalis, and various exogenous chemicals, as well as regulates the local innate immune responses. Therefore, the development of novel oral care products to inhibit inflammatory reactions caused by bacterial infection and protect the gingival epithelium is necessary. Juncus effusus L. has generally been used as an indigenous medicine, such as a diuretic, an antipyretic, and an analgesic, in ancient practice. In this study, we examined the effects of a water extract from J. effusus L. on the inhibition of the inflammatory reaction elicited by bacterial infection and protection of the oral epithelium by chemical irritation. Pretreatment of oral epithelial cells with the water extract from J. effusus L. significantly reduced P. gingivalis or its lipopolysaccharide- (LPS-) mediated production of chemokines (interleukin-8 and C-C-chemokine ligand20) in a concentration-dependent manner with comparable to or greater effects than epigallocatechin gallate and protected oral epithelial cells from injury by chemical irritants, cetylpyridinium chloride, and benzethonium chloride. Moreover, the water extract from J. effusus L. in the presence of antimicrobial agents or antifibrinolytics already used as ingredients in mouthwash could significantly reduce the production of chemokines from P. gingivalis LPS-stimulated oral epithelial cells in a concentration-dependent manner. These findings suggest that the water extract from J. effusus L. is potentially useful for oral care to prevent oral infections, such as periodontal infections, and maintain oral epithelial function.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Protective Effects of Juncus effusus L. Water Extract on Oral Keratinocytes

Wada

Murakami

Ishikawa

et al. 2022

BioMed Research International

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Norsesquiterpenoids from the octocoral Paralemnalia thyrsoides (Ehrenberg 1834)

Phan

Chang

et al. 2022

RSC Adv.

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Phytochemical, ethnomedicinal uses and pharmacological profile of Juncus decipiens (Buchenau) Nakai (common rush)

Ullah

Amen

Nakagawa

2023

Natural Product Research

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Juncus decipiens is a member of the Juncaceae family and has culinary, medicinal, and decorative properties. It is also used in traditional Chinese Medicines for many years that promotes diuresis for strangury and clears out heart fire. This species has recently gained medicinal attention as a source of phenanthrenes, phenolic compounds, glycerides, flavonoids, and cycloartane triterpenes. This plant was also shown to be active, and researchers explored its antioxidant, anti-inflammatory, antialgal, antibacterial, and psychological behaviour-boosting properties. Preliminary research suggests that this species might be used for skin protection and brain disorders if proper clinical trials are conducted. The ethnomedicinal, phytochemistry, biological potencies, dangers, and scopes of Juncus decipiens have been examined in this respect.

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Estrogenic and anti-neutrophilic inflammatory phenanthrenes from Juncus effusus L.

Cited by 3 publications

References 30 publications

Anti-Inflammatory and Protective Effects of Juncus effusus L. Water Extract on Oral Keratinocytes

Anti-Inflammatory and Protective Effects of Juncus effusus L. Water Extract on Oral Keratinocytes

Norsesquiterpenoids from the octocoral Paralemnalia thyrsoides (Ehrenberg 1834)

Phytochemical, ethnomedicinal uses and pharmacological profile of Juncus decipiens (Buchenau) Nakai (common rush)

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