Natural products and traditional medicine products with known safety profiles are a promising source for the discovery of new drug leads.

No abstract

N- [(3-(3-methyl-1-oxo-butyl)amino)propyl]-3- (3,4-dihydroxyphenyl)prop-2-enamide (7), named "Bassiamide A", a new alkaloid, together with six known compounds including one lignan (1) and five lignanamides (2-6), were isolated from the aerial parts of Bassia indica Wight. The study also reported an optimal separation of a rare occurring R-isomer lignanamide derivative (6) from a natural origin, in addition to its known corresponding Sisomer (5). Structures of isolated compounds were elucidated based on NMR spectroscopic data, HR-MS, and comparison with known related ones, and they were identified as syringaresinol (1), N-trans-feruloyl-3-methoxytyramine (2), N-trans-feruloyltyramine (3), S-(-)-N-trans-feruloyl normetanephrine (4), S-(-)-N-trans-feruloyl octopamine (5), R-(+)-N-trans-feruloyl octopamine (6). The isolated compounds were evaluated for their antiacetylcholinesterase activity, and they showed weak inhibitory activity.