Uterine Tumor Resembling Ovarian Sex Cord Tumors Treated by Resectoscopic Surgery

Garuti, Giancarlo; Gonfiantini, Cristina; Mirra, Maurizio; Galli, Carlo; Luerti, Massimo

doi:10.1016/j.jmig.2008.12.006

Cited by 27 publications

(22 citation statements)

References 23 publications

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“…The long-term clinical behaviors of UTROSCT are less aggressive than ESTSCLE (4,18). The recurrence rate is approximately 13% in sex-cord-like uterine tumors, but most include ESTSCLE (45).…”

Section: Discussionmentioning

confidence: 99%

Recurrence in uterine tumors with ovarian sex-cord tumor resemblance: a case report and systematic review

Cömert

Kılıç²,

Çavuşoğlu³

et al. 2018

TJPATH

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Objective: The aim of this study was to evaluate the prognostic factors of recurrence in uterine tumors resembling ovarian sex-cord tumors (UTROSCT) and to determine clinical-pathological characteristics, treatment options and outcome. Material and Method:An electronic literature search was conducted from 1976 to 2018. After the comprehensive evaluation and conjunction with our case, the study included 79 cases. Results:The median age at initial diagnosis was 49 years (range; 16-86 years). The age was under 40 years in 21 (26.6%) patients. Whereas 68 patients underwent at least hysterectomy, 9 patients had organ sparing surgery. There was necrosis in 4 (5.1%) patients, atypia in 16 (20.3%) patients, and infiltrative tumor border in 34 (43%) patients. At least one mitosis per 10 high power fields was determined in 36 (45.5%) patients. The tumor involved at least part of the myometrium in 54 (68.3%) patients. Median follow-up time was 30 months (range; 3-296 months). Recurrence was determined in 5 (6.3%) patients. The disease free survival (DFS) was significantly related only to surgery type. None of the pathologic features were associated with DFS. The 5-year DFS was 86% and 96% in patients who underwent organ sparing surgery or not, respectively (p=0.038). Conclusion:The accurate pathologic diagnosis of UTROSCT has great value in shaping surgical management and management during the follow-up period. Organ sparing surgery was related to poor DFS. Although recurrence is rare, it should be kept in mind for patients with UTROSCT.Key Words: Uterine neoplasms, Recurrence, UTROSCT, Surgery, Prognosis INTRODUCTIONUterine tumors with sex-cord-like elements can be divided into two groups. The first group of tumors is called endometrial stromal tumors with sex cord-like elements (ESTSCLEs) involving endometrial stromal neoplasms with focal areas (<50%) resembling ovarian sex-cord elements. The second group of tumors is called uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) corresponding to uterine tumors with a predominant or exclusive pattern similar to ovarian sex-cord tumors (1, 2). This morphologic differentiation is clinically significant because these tumors have different biological behaviors. ESTSCLE has a tendency for recurrence and metastases, whereas UTROSCT usually shows more benign clinical behavior (3). UTROSCTs rarely recur and are thus considered uterine tumors with low malignant potential (4). UTROSCTs are extremely rare tumors mostly documented as case series in the literature; therefore, it is difficult to draw a distinct conclusion about the management or recurrence rates of these tumors.In this study, a recurrent case of UTROSCT is presented. This analysis evaluated prognostic factors related to UTROSCT recurrence and determined clinicalpathological characteristics, treatment options, and outcomes of UTROSCT. CASE REPORTA 61-year-old patient was referred to our gynecologiconcology clinic because of a UTROSCT diagnosis. She underwent total abdominal hysterectomy (TAH) and bilateral...

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Section: Discussionmentioning

confidence: 99%

Recurrence in uterine tumors with ovarian sex-cord tumor resemblance: a case report and systematic review

Cömert

Kılıç²,

Çavuşoğlu³

et al. 2018

TJPATH

View full text Add to dashboard Cite

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“…Garuti et al 61 reported a rare case of uterine tumor resembling ovarian sex cord tumors treated by resectoscopic surgery. After definitive diagnosis, the patient was followed up, and a control H/S and endometrial biopsy 2 months after initial surgery revealed no residual disease.…”

Section: Conservative Surgical Treatment Hysteroscopic Resectionmentioning

confidence: 99%

Fertility-Sparing Therapy in Young Women With Endometrial Cancer

Erkanli

Ayhan

2010

International Journal of Gynecological Cancer

112

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Endometrial cancer (EC) in young and especially null gravid women is a challenging problem with increasing frequency due to both detailed investigations for infertile couples seeking treatment in in vitro fertilization centers and women delaying their plans for pregnancy. Considering very low number of such cases in the literature, fertility-sparing therapy for EC in young women is not standard, although it is widely used. In this review we searched the relevant literature, reviewed selection criteria, therapeutic options, response rates to therapy, special challenges, reproductive outcomes, and follow-up strategies for young women diagnosed with EC.

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“…Neoplasms showing an exclusive sex cord-like differentiation or focal low-grade sarcoma differentiation, designated as UTROSCTs, are even rarer with only 48 cases described earlier (12). Generally, this subtype of neoplasm is characterized by a benign course (2,13,14).…”

Section: Clinicopathologic Features Of Utrosctmentioning

confidence: 99%

“…To our knowledge, only 3 earlier case reports of UTROSCTs were treated by conservative management (11,12,20,38). In all of these examples, the women were young (range: 28-32 y) and because they were keen to remain fertile, they opted for hysteroscopic resection.…”

Section: Clinicopathologic Features Of Utrosctmentioning

confidence: 99%

Clinicopathologic Features of 2 New Cases of Uterine Tumors Resembling Ovarian Sex Cord Tumors

Giordano

Lombardi²,

Brigati³

et al. 2010

International Journal of Gynecological Pathology

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Uterine neoplasms showing an exclusive sex cord-like differentiation or focal low-grade sarcoma differentiation, designated as uterine tumors resembling ovarian sex cord tumors (UTROSCTs), are rare, with only 48 cases described earlier in international literature. Generally, this entity is characterized by benign behavior. In this study, we report the clinical and pathologic features of 2 peculiar new cases of UTROSCTs. In these examples, the pathologic diagnosis of UTROSCT was made incidentally after the clinical diagnosis of a leiomyoma and endometrial polyp. On examination of small biopsies, the diagnosis was facilitated by specific immunohistochemical analysis using markers for the sex cord component. In 1 of these cases, the patient, because of her young age and her desire to preserve her fertility, was only treated by minimally invasive hysteroscopic surgery. In the other case, the neoplasm seemed to be the consequence of tamoxifen treatment for breast carcinoma. After diagnosis, in this second case, the woman underwent hysterectomy that showed a residue of the tumor and cervical metastasis from the earlier breast carcinoma. The differential diagnosis of UTROSCT and the role of immunohistochemistry in confirming a diagnosis are discussed.

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Uterine Tumor Resembling Ovarian Sex Cord Tumors Treated by Resectoscopic Surgery

Cited by 27 publications

References 23 publications

Recurrence in uterine tumors with ovarian sex-cord tumor resemblance: a case report and systematic review

Recurrence in uterine tumors with ovarian sex-cord tumor resemblance: a case report and systematic review

Fertility-Sparing Therapy in Young Women With Endometrial Cancer

Clinicopathologic Features of 2 New Cases of Uterine Tumors Resembling Ovarian Sex Cord Tumors

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