Uterine Sarcomas: Histogenesis and Taxonomy

Ober, William B.

doi:10.1111/j.1749-6632.1959.tb44576.x

Cited by 98 publications

(18 citation statements)

References 22 publications

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“…Endometrial adenofibroma was first described by Ober in 1959 as a benign variant of mixed m€ ullerian tumour composed of epithelial and stromal components. 6 Since then, approximately 30 cases have been reported in the literature. 1,4e16 However, the origin of this m€ ullerian adenofibroma is a continuing source of debate.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic challenges in a rare case of müllerian adenofibroma of the uterus: instructive case and literature review

Skorupskaite

Al‐Nafussi

McKillop

2011

Diagnostic Histopathology

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Section: Discussionmentioning

confidence: 99%

Diagnostic challenges in a rare case of müllerian adenofibroma of the uterus: instructive case and literature review

Skorupskaite

Al‐Nafussi

McKillop

2011

Diagnostic Histopathology

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“…3,11 Adenofibroma of the endometrium was first described by Ober in 1959 as a form of mixed mesodermal tumor, 12 and Abell described the first case of a papillary adenofibroma of endocervical origin in 1971. 13 Adenofibroma, which is composed of a uniform admixture of histologically benign müllerian epithelium and histologically benign stroma, typically occurring in the endometrium, is rare.…”

Section: Discussionmentioning

confidence: 99%

Benign endometrial adenofibroma and polyp in patients receiving tamoxifen: findings on transvaginal ultrasonography and magnetic resonance imaging

Ikuta¹,

Tanaka²,

Mizokami³

et al. 2005

J Med Ultrasonics

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Tamoxifen, a selective estrogen receptor modulator, is widely used to treat breast cancer, but an association has been reported between tamoxifen and the development of endometrial lesions, including endometrial carcinoma, endometrial polyps, and endometrial hyperplasia. There have also recently been a few reports on the relation between tamoxifen and adenofibroma. We present two case reports, one of a patient with a uterine adenofibroma and one of a patient with an endometrial polyp, both of whom received tamoxifen. Cases 1 and 2 are 75- and 65-year-old postmenopausal women, respectively, undergoing tamoxifen therapy. In both cases, endometrial thickening and many small cysts in the uterine cavity were revealed by transvaginal ultrasonography or magnetic resonance imaging. Postoperative microscopic examination confirmed the mass as an adenofibroma in case 1 and as an endometrial polyp in case 2.

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“…Jan duct derivation are present, including leiomyosarcoma. Ahernatively, these tumors may be heterologous with sarcomatous cells exhibiting differentiation extrinsic to mullerian origin, such as chondrosarcoma, liposarcoma, osteosarcoma, and rhabdomyosarcoma (5,6,12,13,21,26,30).…”

Section: Introductionmentioning

confidence: 99%

“…It has been proposed that stem cell precursors present in pluripotent ovarian surface epithelium and/or subcapsular stroma give rise to the epithelial and mesenchymal cells comprising these tumors (6,7). Numerous theories have been postulated to account for the simultaneous development of multiple malignant elements (13,21,26). The collision theory suggests that the independent sarcomatous and carcinomatous cell populations present within mixed mullerian tumors are derived from separate primary sites.…”

Section: Introductionmentioning

confidence: 99%

Cytogenetic, morphologic and oncogene analysis of a cell line derived from a heterologous mixed mullerian tumor of the ovary

Becker

Papenhausen

Widen

1997

In Vitro Cell.Dev.Biol.-Animal

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A cell line was established from a mixed mullerian tumor of the ovary and designated LN1. Histopathologic analysis of the fresh tumor specimen demonstrated a highly aneuploid heterologous tumor comprised of undifferentiated mesodermal components with carcinomatous cells present as a smaller population. Long-term in vitro culture resulted in the establishment of a cell line that exhibits an epithelial-like morphology and expresses epithelial antigens cytokeratin, epithelial membrane antigen, and carcinoma antigen TAG-72. These cells also express mesenchymal intermediate filaments, vimentin, and desmin. Karyotypic analysis revealed a basic triploid pattern with multiple chromosomal abnormalities, most notably an isochromosome of the short arm of five present in three copies. Analysis of oncogene expression revealed that LN1 cells constitutively express mRNA for c-ras, c-erbB2, and p53. The expression of mRNA for cellular oncogenes correlated with the presence of corresponding oncoproteins, p21H-ras, p21K-ras, and p185erB2 and mutant p53 protein. In summary, coexpression of epithelial and mesenchymal antigens by LN1 cells lends support to the hypothesis that epithelial and mesenchymal elements comprising mixed mullerian tumors of the ovary are derived from a common stem cell precursor. Furthermore, this cell line represents a functional in vitro model to evaluate the biologic activities of these unusual and highly aggressive ovarian malignancies.

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Uterine Sarcomas: Histogenesis and Taxonomy

Cited by 98 publications

References 22 publications

Diagnostic challenges in a rare case of müllerian adenofibroma of the uterus: instructive case and literature review

Diagnostic challenges in a rare case of müllerian adenofibroma of the uterus: instructive case and literature review

Benign endometrial adenofibroma and polyp in patients receiving tamoxifen: findings on transvaginal ultrasonography and magnetic resonance imaging

Cytogenetic, morphologic and oncogene analysis of a cell line derived from a heterologous mixed mullerian tumor of the ovary

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