Uterine rhabdomyosarcoma in adults

Pinto, André; Kahn, Richard L.; Rosenberg, Andrew E.; Slomovitz, Brian M.; Quick, Charles M.; Whisman, Michella K.; Huang, Marilyn

doi:10.1016/j.humpath.2018.01.007

Cited by 33 publications

(49 citation statements)

References 20 publications

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“…It is largely a disease of childhood and is the most frequently diagnosed soft tissue tumor found in children, comprising up to nearly 50% of all pediatric soft tissue tumors [2]. RMS can originate anywhere in the body; however, the head and neck region is the most frequent site of RMS involvement in children [3]. Adult RMS is exceedingly uncommon, accounting for less than 4% of all soft tissue sarcomas specifically, and 1% of all malignancies generally [4,5].…”

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confidence: 99%

Primary Uterine Rhabdomyosarcoma in a 54-Year-Old Postmenopausal Woman

Aljehani¹,

Abu‐Zaid²,

Alomar³

et al. 2020

Cureus

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Rhabdomyosarcoma (RMS) is a malignant neoplasm that originates from undifferentiated myogenic progenitor cells. It is predominantly a pediatric disease, and its occurrence in adults is exceedingly rare. Adult primary RMS of gynecologic origin is an uncommon phenomenon, and the cervix is the most frequently involved site. The incidence of adult primary uterine RMS is extremely scarce. Herein, we present the case of primary uterine RMS in a 54-year-old Saudi postmenopausal woman who presented to clinic attention with a six-month history of abdominal pain and vaginal bleeding.

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Section: Introductionmentioning

confidence: 99%

Primary Uterine Rhabdomyosarcoma in a 54-Year-Old Postmenopausal Woman

Aljehani¹,

Abu‐Zaid²,

Alomar³

et al. 2020

Cureus

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“…In the human uterus, all subtypes of rhabdomyosarcoma can occur and similar to rhabdomyosarcoma in other anatomical locations, the pleomorphic subtype is the most prevalent in adults and the embryonal subtype is the most common in children [ 10 , 13 ]. The incidence of the alveolar subtype in the human uterus appears to be low, regardless of patient age [ 10 , 13 ]. In our case, uterine mass and other metastatic masses were considered to be the pleomorphic subtype on the basis of the histological findings and the animal’s age.…”

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“…However, the prognostic relevance of the rhabdomyosarcoma subtypes in animals is unknown [ 2 , 3 ]. In humans, uterine rhabdomyosarcoma generally has a poor prognosis because, in many patients, the tumor is metastasized to other organs at the time of diagnosis [ 13 ]. In humans, the pleomorphic subtype of uterine rhabdomyosarcoma is highly aggressive and associated with a high mortality rate [ 4 ].…”

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“…Uterine leiomyosarcoma should be considered as the principal differential diagnosis for uterine rhabdomyosarcoma. Leiomyosarcoma is more common than rhabdomyosarcoma and can be histologically similar to rhabdomyosarcoma [ 13 ]. It may be especially difficult to differentiate between pleomorphic rhabdomyosarcoma and pleomorphic leiomyosarcoma [ 13 ].…”

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confidence: 99%

“…Leiomyosarcoma is more common than rhabdomyosarcoma and can be histologically similar to rhabdomyosarcoma [ 13 ]. It may be especially difficult to differentiate between pleomorphic rhabdomyosarcoma and pleomorphic leiomyosarcoma [ 13 ]. In our case, we confirmed rhabdomyosarcoma on the basis of the IHC results for SMA and sarcomeric actin.…”

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Uterine metastatic rhabdomyosarcoma in a scimitar-horned oryx (<i>Oryx dammah</i>)

Woo

Lee

et al. 2018

The Journal of Veterinary Medical Science

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A 13-year-old female scimitar-horned oryx (Oryx dammah) died after progressive anorexia, weight loss, and depression. The necropsy showed that the retroperitoneum was compressed by a large white-to-tan uterine mass and on several sections of the mass, the uterine wall was markedly thickened because of ill-defined transmural tumor tissue. Metastatic nodules were detected in the omentum, mesentery, diaphragm, and lung. The genital tract and pulmonary and abdominal nodules exhibited highly pleomorphic sarcoma. The primary and metastatic neoplastic cells showed positive results for vimentin, desmin, and sarcomeric actin, and negative results for smooth muscle actin. Uterine metastatic rhabdomyosarcoma was diagnosed on the basis of the gross, histopathology and immunohistochemistry results.

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