Uterine Residual Disease After Conization in Women Treated for Microinvasive Carcinoma of the Cervix-Evaluation of 607 Cases

Abstract

Objective: to assess the prevalence of residual disease in hysterectomy specimens after conization in women treated for squamous microinvasive carcinoma of the uterine cervix (MIC). A cohort of 607 patients with MIC diagnosed and treated at Campinas State University, Brazil was analyzed. All patients underwent cervical conization and of these, 388 followed by hysterectomy. Residual carcinoma / CIS in the hysterectomy was highly associated with positive endocervical conization margins (p<0,0001), in 171 cases of free conization endocervical margins, 32/171 (18.7%) had residual disease: 20 CIS (11.7%), and 12 MIC (7%).Positive endocervical margins are highly associated with residual disease in hysterectomy specimen (61.1%) so further treatment is mandatory. Conservative treatment should be carefully evaluated.