Uterine Relaxation Potential of Ethanol Leaf Extract of Moringa oleifera Lam. VIA the Muscarinic Receptor Pathway

Ijioma, N.; Madubuike, Kelechi G.; Nwankudu, O.N.; Nwosu, C.; Emelike, Chinedum Uche

doi:10.9734/bjpr/2014/12140

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…The muscarinic receptor is bind to G proteins, resulting in the activation of (PLC) and the formation (InsP3) and diacylglycerol (DAG) (Prestwich and Bolton, 1995) InsP3 causes release of calcium from its cellular stores (Morel et al, 1997). The obtained results were consistent with those recorded by (Ijioma et al, 2014) who stated that, ELMO relaxed the rat's uterine smooth muscles by its action on the uterine muscarinic receptors. ELMO may contain active anticholinergic principles capable of relaxing uterine motility via the muscarinic receptor pathway.…”

Section: Discussionsupporting

confidence: 86%

The Pharmacodynamic Profile of Hydroethanolic Seed Extract of Moringa Oleifera on Intestinal and Uterine Contractility

Elsayed¹,

Elkomy²,

Salah³

2018

Benha Veterinary Medical Journal

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Moringa oleifera is extensively distributed and used in many countries all over the world. The seed of Moringa oleifera is a high value part and has an amazing medicinal and therapeutic uses with high nutritional value. This study, therefore, was designed to clarify the pharmacological effects of hydroethanolic seed extract of Moringa oleifera (HSMO) on isolated intestinal and uterine motility with a view to finding out the site of actions of Moringa oleifera (MO). Tension recording technique was used for studying the effect of Moringa oleifera seeds extract on isolated rabbit's duodenum, guinea pig's ileum, rat's colon and uterus. Results obtained showed that HSMO produced a concentrations dependent relaxation of intestinal muscle. The minimal effect of MO was observed at concentration of 4 μg/ml bath that produced 6.3% inhibition of duodenum contractility. Complete relaxation of duodenum smooth muscle was established after the addition of MO at concentration of 512 μg/ml bath. While in isolated guinea pig's ileum and rat's colon, complete inhibition was established after the addition of MO at concentration of 256 μg/ml bath. HSMO inhibited the contractility of rat's uterus during nonpregnant and pregnant stages. Complete relaxation was attained by addition of 256 µg of MO extract /ml bath. The inhibitory action of MO could be attributed to, at least partly, its action on muscarinic receptors, indicated by decreasing stimulant effect of Ach. The phytochemical screening of Moringa oleifera seeds in our investigation indicated the presence of flavonoids and tannins and these components play a key role in spasmolytic activity by blocking muscarinic receptors. It could be concluded that, MO may have a depressant effect on intestinal and uterine muscles via muscarinic cholinergic pathway. These data may support the effective and safe use of MO in gastrointestinal disorders and pregnancy and these finding may give evidence to its traditional use on the management of intestinal ailments such as pains, diarrhea and dysentery.

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Section: Discussionsupporting

confidence: 86%

The Pharmacodynamic Profile of Hydroethanolic Seed Extract of Moringa Oleifera on Intestinal and Uterine Contractility

Elsayed¹,

Elkomy²,

Salah³

2018

Benha Veterinary Medical Journal

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“…Recent studies have reported that C. olitorius leaf extracts significantly reduced the amplitudes of uterine tissue contraction dose-dependently, with the highest dose (666.67 μg/mL) achieving a 100% inhibitory effect, and significant inhibition of oxytocin-induced contractions was also seen [ 22 ]. Significant smooth relaxing effects of the uterine and gastrointestinal muscles, possibly due to their molecular interactions with receptors, inhibited contractions of the smooth muscles for extracts rich in flavonoids [ 104 ]. According to Parvin et al 2015, a methanolic extract of C. olitorius aerial parts had a significant impact on reducing the number of abdominal constrictions induced by acetic acid through intraperitoneal administration [ 105 ].…”

Section: Biological Activitymentioning

confidence: 99%

A Comprehensive Review of C. capsularis and C. olitorius: A Source of Nutrition, Essential Phytoconstituents and Pharmacological Activities

et al. 2022

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Plant bioactive compounds have gained global significance in terms of both medicinal and economic ramifications due to being easily accessible and are believed to be effective with fewer side effects. Growing relevant clinical and scientific evidence has become an important criterion for accepting traditional health claims of medicinal plants and also supports the traditional uses of Corchorus as folk medicine. C. capsularis and C. olitorius have broad applications ranging from textile to biocomposite, and young leaves and shoots are used as healthy vegetables and have long been used as traditional remedies for fever, ascites, algesia, liver disorders, piles, and tumors in many cultures. This review systematically summarized and emphasized the nutritional attributes, mostly available bioactive compounds, and biological and potential pharmaceutical properties of C. capsularis and C. olitorius, disclosed to users and non-users. Results suggest that various phytochemicals such as cardiac glycosides, phenols, flavonoids, sterols, lipids, and fatty acids were found or analytically identified in different plant parts (leaf, stem, seed, and root), and many of them are responsible for pharmacological properties and their antitumor, anticancer, antioxidant, antinociceptive, anti-inflammatory, analgesic, antipyretic, antiviral, antibacterial, anticonvulsant, antidiabetic and antiobesity, and cardiovascular properties help to prevent and cure many chronic diseases. In addition to their use in traditional food and medicine, their leaves have also been developed for skin care products, and some other possible uses are described. From this review, it is clear that the isolated compounds of both species have great potential to prevent and treat various diseases and be used as functional foods. In conclusion, this comprehensive review establishes a significant reference base for future research into various medical and functional food applications.

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Gastrointestinal and uterine smooth muscles relaxant and anti-inflammatory effects of corchorus olitorius leaf extract in laboratory animal models

Orieke

Ohaeri

Ijeh

et al. 2020

Journal of Ethnopharmacology

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Uterine Relaxation Potential of Ethanol Leaf Extract of Moringa oleifera Lam. VIA the Muscarinic Receptor Pathway

Abstract: Aim:The effect of Ethanol Leaf Extract of Moringa oleifera (ELMO) on uterine smooth muscles of non-pregnant female rats was studied in vitro with a view to finding out the mechanism(s) for observed effects.

Cited by 4 publications

References 9 publications

The Pharmacodynamic Profile of Hydroethanolic Seed Extract of Moringa Oleifera on Intestinal and Uterine Contractility

The Pharmacodynamic Profile of Hydroethanolic Seed Extract of Moringa Oleifera on Intestinal and Uterine Contractility

A Comprehensive Review of C. capsularis and C. olitorius: A Source of Nutrition, Essential Phytoconstituents and Pharmacological Activities

Gastrointestinal and uterine smooth muscles relaxant and anti-inflammatory effects of corchorus olitorius leaf extract in laboratory animal models

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