Uterine low grade endometrial stromal sarcoma: a case report with review of literature

Devi, P. Urmila; Himaja, S.; Manasa, R.; Atla, Bhagya Lakshmi

doi:10.18203/2320-6012.ijrms20150665

Cited by 4 publications

(7 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 6 ] Low-grade ESS shows <10 mitoses per 10 HPF whereas a high-grade ESS shows more than 10 mitotic figures per 10 HPF. [ 4 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 2 7 ] Imaging studies such as ultrasonography and magnetic resonance imaging are often inconclusive as it is diagnosed as a leiomyoma or a benign pelvic mass. [ 4 ] Endometrial curettage scrapes the superficial lining only and myometrium is not included; hence, the procedure is of little diagnostic help for definitive diagnosis of stromal tumors. ESS has a propensity to grow intramurally in the uterus rather than intracavitary portion as in endometrial carcinomas.…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 30% cases of low-grade ESS have an extrauterine disease at the time of presentation; rarely, these tumors may initially present at other extrauterine sites, most commonly ovary. [ 4 ]…”

Section: Discussionmentioning

confidence: 99%

“…Total abdominal hysterectomy with bilateral salpingo-oophorectomy with pelvic and periaortic selective lymphadenectomy is the treatment of choice. [ 4 ] For stage 3/4 low-grade ESS and recurrent disease, hormonal therapy with medroxyprogesterone, tamoxifen, gonadotropin-releasing hormone analogs, and aromatase inhibitors has been suggested. [ 2 8 ] There will be no reoccurrence in 75% patients with stage 1 disease if treated with adjuvant medroxyprogesterone acetate as compared with 29% with same stage patients in which adjuvant therapy with medroxyprogesterone is not given.…”

Section: Discussionmentioning

confidence: 99%

“…Patients usually present with heavy menstrual bleeding, pain abdomen, and enlarged uterus. [ 4 ] ESSs due to their low incidence are difficult to diagnose preoperatively and detected only after histopathological examination of the resected hysterectomy specimen. ESS is commonly associated with various chromosomal aberrations, of which deletion of chromosome 7p is most common.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Low-grade endometrial stromal sarcoma in a postmenopausal woman with third-degree uterovaginal prolapse: A rare case with review of the literature

et al. 2018

View full text Add to dashboard Cite

Endometrial stromal sarcomas (ESSs) are rare malignant tumors of the uterus that arise from the endometrial stroma, the annual incidence of ESS being 1–2/million women. Patients present with nonspecific complaints of abnormal uterine bleeding, pelvic pain, and pressure symptoms. Postmenopausal women rarely present with a low-grade ESS, as it is more common in younger women. ESS is usually confused with leiomyomas radiologically. Histopathological examination and immunohistochemistry are essential for the diagnosis. We, herein, report a case of a postmenopausal female who presented with something coming out per vagina. The clinical impression was that of a third-degree uterovaginal prolapse that on histopathological examination was diagnosed as a low-grade ESS.

show abstract

“…[ 6 ] Low-grade ESS shows <10 mitoses per 10 HPF whereas a high-grade ESS shows more than 10 mitotic figures per 10 HPF. [ 4 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Low-grade endometrial stromal sarcoma in a postmenopausal woman with third-degree uterovaginal prolapse: A rare case with review of the literature

et al. 2018

View full text Add to dashboard Cite

show abstract

Immunohistochemical and Molecular Characterization of Endometrial Stromal Sarcomas

Subbaraya

Murthy

2020

Clin Med�Insights�Pathol

View full text Add to dashboard Cite

Introduction: Endometrial stromal sarcomas (ESSs) are rare and characterized by translocations t(7;17)(p15;q11.2) and t(10;17)(q22;p13), resulting in JAZF1-SUZ12 and YWHAE-FAM22 gene fusions used for defining low-grade (LG-ESS) and high-grade (HG-ESS) tumours. Aim: The objective of the study was to characterize ESSs using immunohistochemical and molecular markers. Material and Methods: Patients diagnosed as having ESSs between January 2014 and December 2018 were included in the study. The slides were reviewed along with a panel of immunohistochemical markers, CD10, cyclin D1, oestrogen receptor (ER) and progesterone receptor (PR), Ki67, and vimentin and classified according to World Health Organization (2014) criteria into LG-ESS, HG-ESS, and undifferentiated uterine sarcoma (UUS). Molecular characterization was performed by fluorescence in situ hybridization using relevant probes. Results: Over a 4-year period, 552 cases of endometrial malignancies were reported, 10 of which were ESS (1.8%). Of these, 5 were LG-ESS, 3 HG-ESS, and 2 UUS. CD10 was 100% sensitive and 75% specific for LG-ESS. Oestrogen receptor and PR were 100% specific but less sensitive (80%) for LG-ESS. Forty per cent (2/5) of LG-ESS demonstrated JAZF1-SUZ12 gene rearrangement. All 3 cases of HG-ESS showed diffuse strong cyclin D1 (>70% nuclei) positivity and were negative for cluster differentiation 10, ER, and PR and demonstrated YWHAE gene rearrangement. None of the UUS cases demonstrated this gene rearrangement. Conclusion: Endometrial stromal sarcomas are rare tumours (1.8% in this study). JAZF1-SUZ12 and YWHAE-FAM22 gene rearrangement helps in accurate characterization of ESS and can be used as diagnostic tools especially when the diagnosis is unclear or difficult. Cyclin D1 can be used as an adjuvant immunomarker for YWHAE gene–rearranged HG-ESS.

show abstract

Low-Grade Endometrial Stromal Sarcoma in a Young Woman: A Case Report

Talayeh

Arab

Teymoordash³

et al. 2022

J Obstet Gynecol Cancer Res

View full text Add to dashboard Cite

Endometrial stromal sarcoma is a rare condition, constituting nearly 0.2% of all reproductive tract malignancies. The condition mainly affects the peri-menopausal population; however, it can occasionally be found in younger women and adolescents.Here, this is a case of a 20-year-old primiparous female who was referred to us with the main complaint of vaginal bleeding (menometrorrhagia), ongoing for 6 months after delivery. Her sonography report indicated a 5 cm intra-cavitary mass suspicious for myoma or placental polyp. Given the pathology report of low-grade endometrial stromal sarcoma (LGESS) on samples obtained through hysteroscopy and D&C, she underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH+BSO). Endometrial stromal sarcoma is a rare uterine malignancy of mesenchymal origin that should be considered, even in very young patients.

show abstract

Uterine low grade endometrial stromal sarcoma: a case report with review of literature

Cited by 4 publications

References 3 publications

Low-grade endometrial stromal sarcoma in a postmenopausal woman with third-degree uterovaginal prolapse: A rare case with review of the literature

Low-grade endometrial stromal sarcoma in a postmenopausal woman with third-degree uterovaginal prolapse: A rare case with review of the literature

Immunohistochemical and Molecular Characterization of Endometrial Stromal Sarcomas

Low-Grade Endometrial Stromal Sarcoma in a Young Woman: A Case Report

Contact Info

Product

Resources

About