Uterine Leiomyosarcoma: A Case Report

Forghani, Fereidoun; Kashi, Abolfazl Mehdizadeh; Sadegi, Kambiz; Kaveh, Mania; Ghafari, Mehrangiz

doi:10.15296/ijwhr.2018.38

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…It was found that 81 (81%) of the women had successful medical abortion and 19 women underwent suction curettage. In a rando-mized, controlled trial designed to compare the methotrexate/misoprostol vs. a more standard approach for termination of pregnancies, the mean interval to the end point in the methotrexate/misoprostol group was higher (26.4 days vs. 4.5 days, p<0.0001) [24] .…”

Section: Discussionmentioning

confidence: 99%

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A Comparative Study between Methotrexate versus Letrozole Prior to Misoprostol in Induction of First Trimester Missed Miscarriage

Bahaa

Ahmed²,

Amen³

et al. 2022

Minia Journal of Medical Research

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Background: Miscarriage is the loss of a pregnancy before the period of viability. In the better resourced parts of the world, fetuses weighing 500 g or more or a gestational age above 24 weeks can survive although they may be handicapped. A missed miscariage is a nonviable intrauterine pregnancy that has been retained within the uterus without spontaneous abortion. Aim is to compare the synergistic effect of methotrexate versus letrozole before misoprostol for induction of first trimester missed miscarriage. Method: The study was conducted at Minia University Hospital and Eledwa General Hospital in the period from February 2021 to February 2022. The study included 199 women randomly allocated into two groups: Group (A): 99 women received letrozole (2.5 mg×3 tablets/day) + misoprostol (200 μg)/8h for 3 days], and Group (B): 100 women received [methotrexate (50 mg) im+ misoprostol (200 μg)/8h for 3 days]. Result: Both letroazole and methotrexate are effective in increasing the efficiency of misoprostol in inducing first trimester missed with a better side effects profile in the letrozole group. Conclusion: Letrozole administration prior to misorostol can be a safe and effective treatment in inducing first trimester missed miscarriage.

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Section: Discussionmentioning

confidence: 99%

“…In a study conducted by Rudasari et al, [24] in Mashhad (2004Mashhad ( -2006 on 100 pregnant women at their first trimester, the effect of Methotrexate and Misoprostol on the success rate of abortion was investigated. It was found that 81 (81%) of the women had successful medical abortion and 19 women underwent suction curettage.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study between Methotrexate versus Letrozole Prior to Misoprostol in Induction of First Trimester Missed Miscarriage

Bahaa

Ahmed²,

Amen³

et al. 2022

Minia Journal of Medical Research

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show abstract

“…In a study conducted by Rudasari et al in Mashhad (2004Mashhad ( -2006 on 100 pregnant women at their first trimester, the effect of Methotrexate and Misoprostol on the success rate of abortion was investigated. It was found that 81 (81%) of the women had successful medical abortion and 19 women underwent suction curettage (16).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Induction Abortion in the First Trimester Using Misoprostol Alone and Misoprostol With Estrogen Priming

Teimoori

Esmaeilpoor

Ashkezari

et al. 2019

International Journal of Women’s Health and Reproduction Scienc

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Objectives: Miscarriage is defined as the loss of pregnancy before the 20 weeks of gestational age. This study was conducted to compare the induction abortion in the first trimester using misoprostol alone and misoprostol with estrogen priming. Materials and Methods: This clinical trial was conducted in Ali ibn-e Abitalib hospital of Zahedan in 2017. A total of 100 women with missed abortions under 14 weeks of gestational age were evaluated. The women were randomly assigned into the misoprostol alone and misoprostol with estrogen priming groups. Ultrasound was done to evaluate the presence of remnants 4 hours after the abortion. If it was less than 10 mm, the abortion was considered successful. Results: The success rate was 38% in the misoprostol group and 86% in the misoprostol with estrogen priming group. Conclusions: Overall, this study showed that estrogen increases the success rate of abortion and reduces the time to abortion.

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“…LMS is usually diagnosed following the surgery , although in rare conditions, a frozen section is used during the surgery. 6 In most cases, the diagnosis of LMS is made by pathological examination of hysterectomy or myomectomy specimen. 5 Here we present an extremely rare case of uterine LMS coexisting with endometrial endometrioid adenocarcinoma of the uterus.…”

mentioning

confidence: 99%

A Rare Case of Synchronous Uterine Leiomyosarcoma and Endometrial Endometrioid Adenocarcinoma

et al. 2023

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Assessment Synchronous primary neoplasms are defined when two or more neoplasms take place concurrently in the same patient. Concomitant endometrial adenocarcinoma and uterine leiomyosarcoma are extremely rare. Here we present an extremely rare case of uterine leiomyosarcoma coexisting with endometrial endometrioid adenocarcinoma of the uterus. A 52 years old woman was reported to a gynecology outpatient clinic with chief complaints lower abdominal pain, severe dysmenorrhea, and irregular vaginal bleeding for 7 months. Ultrasound of pelvis and abdomen showed a solitary intramural fibroid measuring 10x10cm. Surgery was planned and a simple total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed and specimen was sent to the laboratory for examination. Histopathological examination from intramural mass showed high-grade leiomyosarcoma, spindle cell type with less than 50% of myometrial invasion. Sections from thickened endometrium showed endometrial endometrioid adenocarcinoma, FIGO grade I with an invasion of superficial fascicles of myometrium (<50%). Morphological diagnosis was supported by Immunohistochemistry. Here we report an exceptionally rare case of synchronous uterine leiomyosarcoma and endometrial endometrioid adenocarcinoma. Our study may contribute to understand the prognosis of such multiple malignancies, common associations, and etiology of the disease so that a proper plan for further management of the patient can be implemented.

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Uterine Leiomyosarcoma: A Case Report

Cited by 3 publications

References 7 publications

A Comparative Study between Methotrexate versus Letrozole Prior to Misoprostol in Induction of First Trimester Missed Miscarriage

A Comparative Study between Methotrexate versus Letrozole Prior to Misoprostol in Induction of First Trimester Missed Miscarriage

Comparison of Induction Abortion in the First Trimester Using Misoprostol Alone and Misoprostol With Estrogen Priming

A Rare Case of Synchronous Uterine Leiomyosarcoma and Endometrial Endometrioid Adenocarcinoma

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