Uterine histopathological changes induced by acute administration of tamoxifen and its modulation by sex steroid hormones

Sá, Susana I.; Maia, J. Costa; Bhowmick, Niloy; Silva, Samuel M.; Silva, Ana; Correia-da-Silva, Georgina; Teixeira, Natércia; Fonseca, Bruno M.

doi:10.1016/j.taap.2018.11.015

Cited by 6 publications

(2 citation statements)

References 47 publications

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“…The interaction between ESR1 and BECLIN1 could potentially in uence the functions of both BECLIN1 and ESR1 as downstream targets of miRNA-222. It is conceivable that a reciprocal regulatory mechanism between BECLIN1 and ESR1 might yield unfavorable outcomes, including the negative modulation of ESR1 [59]. Furthermore, endometrial hyperplasia seems to be dependent on ESR1 activation [60].…”

Section: Discussionmentioning

confidence: 99%

Chitosan/Alginate-loaded Astragalus hamosus shows ameliorating effects on lipid profile, inflammatory and hormonal parameters, and reduces miRNA-222 expression in Polycystic Ovary Syndrome Rats

Bostani,

Kohnehshahri,

Tabatabaei

et al. 2024

Preprint

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Objective This study aimed to investigate the effects of Chitosan/Alginate-loaded Astragalus hamosus extract (AH) on the expression of miRNA-222 and ESR1 genes, pro-inflammatory cytokines, lipid profiles, and sex hormone levels in rats with PCOS-induced by estradiol valerate (EV). Methods 25 female Wistar rats, with an average weight of 180 g, were divided into control and PCOS groups. The PCOS model was induced by a single intramuscular injection of EV (4 mg/kg). After 28 days of PCOS induction, the rats were orally administered Chitosan/Alginate-loaded AH at doses of 5, 10, and 15 mg/kg. Following four weeks of treatment, histological and biochemical parameters, pro-inflammatory cytokines, body weight, and the expression of miRNA-222 and ESR1 genes were evaluated. Results EV-induced PCOS rats exhibited a significant increase in body weight, abnormal lipid profiles, elevated pro-inflammatory cytokine levels, altered sex hormone levels, upregulation of miRNA-222 expression, and downregulation of ESR1 gene expression. The administration of Chitosan/Alginate-loaded AH (Chn/Al-AH) demonstrated ameliorative effects on the PCOS rats, restoring both endocrine and metabolic abnormalities to normal levels and attenuating complications in EV-induced PCOS rats. Notably, it significantly reduced miRNA-222 expression and promoted follicular development at various stages while reducing cystic follicles and increasing corpus luteum formation. Conclusions Chn/Al-AH was found to have beneficial effects in attenuating and improving certain complications in the PCOS rat models.

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Section: Discussionmentioning

confidence: 99%

Chitosan/Alginate-loaded Astragalus hamosus shows ameliorating effects on lipid profile, inflammatory and hormonal parameters, and reduces miRNA-222 expression in Polycystic Ovary Syndrome Rats

Bostani,

Kohnehshahri,

Tabatabaei

et al. 2024

Preprint

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“…To estimate the total length of the vessels, the parts of the left uterine horn were cut using isotropic uniform random (IUR) sections procedure ( Figure 1 ). 14 , 15 Each uterine horn segment was sectioned into pieces parallel to the direction of the second cut with a distance of 1 mm, giving rise to 8-12 slabs. The slabs were then held in 10% neutral buffered formalin for tissue procedure.…”

Section: Methodsmentioning

confidence: 99%

Effects of N-acetylcysteine and metformin treatment on the stereopathological characteristics of uterus and ovary

et al. 2022

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In this study, the stereo-pathological effect of metformin and N-acetyl cysteine is evaluated on the uterus and ovary of polycystic ovary syndrome (PCOS) mice. 96 mature females (8-weekold, weight of 20–30 gr) BALB/c mice were classified into 6 groups including the control group (n= 16), letrozole-induced PCOS group (n=16), PCOS + metformin (n=16), PCOS+NAC (n=16) and a separate control group for NAC (n=16). Another PCOS group was maintained for a month to make sure that features remain till the end of the study. Testosterone level, vaginal cytology and stereological evaluations were assessed. Vaginal cytology in letrozole-receiving mice showed a diestrus phase continuity. Testosterone level, body weight, uterine weight, endometrial volume, myometrial volume, gland volume, stromal volume, epithelial volume, vessel volume, daughter and conglomerate glands, endometrial thickness, and myometrial thickness exhibited an increasing trend in the uterus of PCOS mice. While normal gland and vessel length decreased in the PCOS group. Ovarian volume, corticomedullary volume, primary follicles, secondary follicles, and ovarian cysts were increased in PCOS ovaries. While corpus luteum, primordial, graafian, and atretic follicles showed a decline in the PCOS group. NAC and metformin, however, managed to restore the condition to normal. Given the prevalence of PCOS and its impact on fertility, the use of noninvasive methods is of crucial significance. NAC can control and treat pathological parameters and help as a harmless drug in the treatment of women with PCOS.

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Acute uterine effects and long-term reproductive alterations in postnatally exposed female rats to a mixture of commercial formulations of endosulfan and glyphosate

Ingaramo

Schimpf

Milesi

et al. 2019

Food and Chemical Toxicology

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Uterine histopathological changes induced by acute administration of tamoxifen and its modulation by sex steroid hormones

Cited by 6 publications

References 47 publications

Chitosan/Alginate-loaded Astragalus hamosus shows ameliorating effects on lipid profile, inflammatory and hormonal parameters, and reduces miRNA-222 expression in Polycystic Ovary Syndrome Rats

Chitosan/Alginate-loaded Astragalus hamosus shows ameliorating effects on lipid profile, inflammatory and hormonal parameters, and reduces miRNA-222 expression in Polycystic Ovary Syndrome Rats

Effects of N-acetylcysteine and metformin treatment on the stereopathological characteristics of uterus and ovary

Acute uterine effects and long-term reproductive alterations in postnatally exposed female rats to a mixture of commercial formulations of endosulfan and glyphosate

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