Uterine histology and prostaglandin concentrations and utero-ovarian venous steroid and prostaglandin concentrations during the luteal phase of the menstrual cycle in baboons (Papio spp.) with or without an IUD

Wheeler, A. G.; Hurst, Philip; Poyser, N.L.; Eckstein, Peter P.

doi:10.1530/jrf.0.0670035

Cited by 7 publications

(2 citation statements)

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“…Mossman (1937) clearly pointed out the differences in the response to pregnancy of some stromal cells (conversion to decidual cells) and of many epithelial cells fiyperplasia, conversion to multinucleate or giant cells, etc.). Nevertheless many authors still refer to epithelial plaque cells as decidual cells, or as deciduomal cells in the case of artificial stimuli (Rossman, 1940;Marston et al, 1971;Wheeler et al, 1983). In some cases it is not clear that a distinction has been made (Wadsworth et al, 1980).…”

Section: Discussionmentioning

confidence: 99%

Implantation in the rhesus monkey: Endometrial responses

1985

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In this continuing series of studies of implantation in the rhesus monkey, eight specimens, ranging in gestation age from 9.5 days to 16.5 days after ovulation, were examined with a focus on localized modifications in the endometrium as a response to implantation. Additionally, evidence of continuing changes in early pregnancy was provided by three specimens at the end of the first month of gestation (days 24, 28, and 35). The responses of the endometrium to pregnancy start with a localized accumulation of stromal eosinophils, which is rapidly followed by epithelial plaque formation in the basal cells of the luminal epithelium and gland necks. Plaque cells hypertrophy, develop marginal dense granules, and accumulate glycogen. They form a pad underlying the margins but not the central zone of the implantation site. However, some degenerating plaque cells are found as early as day 15; and little more than a region of leukocytic infiltration remains of the plaque by day 35. Shortly after the plaque response is initiated there is a striking subepithelial edema surrounding the plaque, and the venular capillaries enlarge by engorgement and by endothelial hyperplasia. The endothelial cells subsequently hypertrophy, resulting in a largely columnar endothelium. There is a localized decidual cell response, consisting of an increase in rough endoplasmic reticulum and in filaments, but only a moderate amount of hypertrophy of these cells. Endometrial granular cells become more conspicuous in the area as they accumulate glycogen. Patches of large pale cells appear in the lumen and walls of arterioles subjacent to the implantation site, but the cytology of these cells provided insufficient clues to their origin (cytotrophoblast?). Although the endometrial responses described are impressive and diverse, their advantages to the organism are not obvious. The hypertrophy of the anastomotic capillary bed that accompanies plaque formation may well provide an extensive vascular network available to the developing trophoblastic lacunae. The role of endometrial granular cells, decidual cells, and even plaque cells may be more related to their largely unexplored secretory activity than to their physical contribution to the formation of the basal plate.

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Section: Discussionmentioning

confidence: 99%

Implantation in the rhesus monkey: Endometrial responses

1985

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“…The use of an animal model might allow a systematic evaluation of PID and IUC use. Baboons have been previously used in IUC trials [6,7]. However, while the male baboon is susceptible to infection with C. trachomatis [8], this has not been studied in the female reproductive tract.…”

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confidence: 99%