Uterine fibroids in pregnancy: prevalence, clinical presentation, associated factors and outcomes at the Limbe and Buea Regional Hospitals, Cameroon: a cross-sectional study

Abstract

ObjectivesUterine fibroids are common among the black race and associated with adverse outcomes in pregnancy. The aim of this study was to determine the prevalence, clinical presentation and maternal and foetal outcomes of birth among pregnant women with leiomyoma in two secondary care hospitals in Limbe and Buea, Cameroon.ResultsThe prevalence of fibroid in pregnancy was 16.7%. Respondents with leiomyoma were older than those without (p < 0.001) and of low parity (p = 0.02). Acute abdominal pain, (OR 3.8; 95% CI 1.4–9.9, p = 0.007), vaginal bleeding (OR 5.2; 95% CI 1.6–16.3, p = 0.004) were clinical presentation of leiomyoma in pregnancy. Cesarean birth (OR 4.5; 95% CI 1.4–13.6, p = 0.008), low Apgar score, (OR 6.0; 95% CI 1.9–19.1, p = 0.002), and postpartum hemorrhage (OR 4.7; 95% CI 1.7–13.2, p = 0.003) were adverse outcomes recorded.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-4007-0) contains supplementary material, which is available to authorized users.

Uterine fibroids and preterm birth risk: A systematic review and meta‐analysis

“…Finally, 19 articles (18 studies) were included in this meta-analysis. [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] One of these papers reported complementary information to the primary outcome information. 35,38 The selection process is shown in Figure 1.…”

“…26,33,35,38,41 There were also 13 case-control studies, including 10 270 pregnant women with UF and 150 795 control women without UF. 24,25,[27][28][29][30][31][32][34][35][36][37]40,42 In all included studies, the presence or absence of UF was determined by ultrasound examination during the first or second trimesters of gestation. Characteristics of the included studies and participants are displayed in Table 1.…”

“…Characteristics of the included studies and participants are displayed in Table 1. Five populations were studied in the United States, 26,29,30,35,39 seven in Europe, 24,25,28,[32][33][34]41 three in Asia, 27,36,42 two in Africa 31,40 and one in Mexico. 37 Two articles reported different results of the same cohort.…”

“…35,38 Studies were published between 1990 29 and 2018. 31,33 Some clinical information was heterogeneously reported ( Table 1).…”

“…[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] In 10 studies, pregnant women with UF were older than those without fibroids (MD = 2.40 years, 95% CI 0.94-3.85, P < 0.001). [24][25][26][30][31][32][33]37,39,40 Six studies also showed the association of UF with preterm birth <34 weeks (RR = 1.79, 95% CI 1.32-2.42, P < 0.001; I 2 = 68%; Figure 2b). 24,26,32,33,36,39 These two associations (<37 and <34 weeks) had moderate degrees of heterogeneity.…”