Uterine body invasion of carcinoma of the uterine cervix as seen from surgical specimens

Noguchi, Hiroshi; Shiozawa, I; Kitahara, Taketo; Yamazaki, Teruyuki; Fukuta, Toru

doi:10.1016/0090-8258(88)90021-2

Cited by 42 publications

(23 citation statements)

References 11 publications

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“…In previous studies, patients with endometrial extension have been shown to have a poor prognosis because of a higher rate of development of distant metastases, [2][3][4][5]18 but there was no explanation of this finding. Narayan et al has shown a correlation between magnetic resonance imaging (MRI) endometrial extension and FDG-PET-detected lymph nodes.…”

Section: Discussionmentioning

confidence: 65%

“…Therefore, we suggest that endometrial extension is correlated with lymph node metastases, which correlates with development of distant metastases and a worse prognosis. [2][3][4][5]18 In the absence of FDG-PET evaluation, evidence of endometrial extension may assist in assessing a patient-s risk of lymph node metastasis. This prognostic information may be useful in stratifying patients for risk-adjusted therapies.…”

Section: Discussionmentioning

confidence: 99%

“…7 Surgical studies have also reported that endometrial extension seen on the radical hysterectomy specimen is associated with a substantial risk of pelvic lymph node metastases and a decreased 5-year survival (93% vs. 54%, P Ͻ 0.001). 3 Endometrial extension demonstrated by magnetic resonance imaging (MRI) was shown to correlate with FDG-PET-detected lymph node metastases. 8 Our recent studies have previously demonstrated that outcomes in cervical carcinoma are more accurately predicted by FDG-PET evidence of lymph node metastases than by FIGO stage.…”

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confidence: 99%

“…[2][3][4][5] Staging systems of cervical carcinoma, including the League of Nations system, included endometrial invasion as a distinguishing criterion, 6 but this factor is not used in the current International Federation of Gynecology and Obstetrics (FIGO) staging system. Perez and colleagues showed that endometrial invasion by cervical cancer was a significant negative prognostic factor associated with a 10 -20% decrease in overall survival among irradiated patients of the same stage.…”

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confidence: 99%

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FDG‐PET in carcinoma of the uterine cervix with endometrial extension

Hope

Saha

Grigsby

2005

Cancer

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BACKGROUNDThe authors wished to determine whether pretreatment pathologic evidence of endometrial invasion correlated with fluorine‐18 fluorodeoxyglucose positron emission tomography (FDG‐PET) findings and outcomes in patients with carcinoma of the uterine cervix.METHODSPretreatment whole body FDG‐PET was performed in 58 patients with cervical carcinoma who also underwent pathologic evaluation of the endometrium by biopsy or dilation and curettage. FDG‐PET lymph node status, disease free survival, and overall survival were evaluated.RESULTSThirty seven (64%) patients had pathologic evidence of endometrial invasion. Pelvic lymph node metastases were three times more frequent in patients with evidence of endometrial invasion compared with those without endometrial invasion (70% vs. 23%, P < 0.001). Patients with endometrial invasion also had a significantly increased risk of paraaortic and supraclavicular lymph node metastases at presentation (30% vs. 0% P = 0.006). Endometrial invasion was associated with a decreased 2‐year disease‐free survival (78% vs. 58%, P = 0.046) and overall survival (92% vs. 65%, P =0.047).CONCLUSIONSEndometrial extension in cervical cancer correlated strongly with risk of FDG‐PET detected lymph node metastases in this study's population and was associated with a poor prognosis. Cancer 2006. © 2005 American Cancer Society.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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FDG‐PET in carcinoma of the uterine cervix with endometrial extension

Hope

Saha

Grigsby

2005

Cancer

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“…The more we know about the importance of the individual risk factors, the better we are able to exactly differentiate between high-risk and low-risk patients. At present, however, pathohistological criteria are almost exclusively considered as risk fac tors [14][15][16][19][20][21][22][23]. Immunological factors, the psychological situation of the patient, her general condition and nicotine abuse have as yet hardly been taken into consideration in therapy recommendations, although there are indications of psychological influence on immunological reactions against tumors [24,25], For more than a decade it has been known from epidemiolo gical studies that nicotine abuse is associated with the develop ment of different types of carcinoma, including cervical carci noma [1][2][3][4][5].…”

Section: Commentmentioning

confidence: 99%

Nicotine Abuse as a Prognostic Factor in Stage Ib Cervical Carcinoma

et al. 1992

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Background: The present retrospective study attempts to evaluate the significance of nicotine abuse as a prognostic factor for cervical carcinoma in addition to factors such as histological type, adjuvant radiotherapy, age, histological grading, tumor infiltration of the corpus uteri, tumor size and lymph node metastases. Patients and Methods: Between 1981 and 1987, 163 patients operated at our department or referred to postoperative radiotherapy fulfilled the inclusion criteria: histopathological stage lb (International Federation of Gynecology and Obstetrics, FIGO) radical hysterectomy with pelvic lymphadenectomy, and known history of smoking. Results: Univariate and multivariate analyses confirmed that in addition to the factors tumor size [tumor infiltration of the cervix > 2/3 vs. < 2/3: relative risk (RR) = 4.48; 95% CI = 1.28 -15.72] and pelvic lymph node metastases (positive vs. negative: RR = 3.63; 95% CI = 1.53-8.60). nicotine abuse (yes vs. no: RR = 3.03; 95% CI = 0.14-0.75) is of significant importance for the relapse-free survival. Conclusion: Therefore smokers suffering from cervical carcinoma should be considered as a high-risk group.

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Neoplasms of the Cervix

Jhingran

Rodrı́guez

2017

Holland‐Frei Cancer Medicine

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Overview Cervical cancer is the third most common cancer among women worldwide and the fourth leading cause of cancer deaths in females, with an estimated 529,800 new cases and 275,100 deaths in the year 2008. The incidence is declining in the United States with 12,900 new cases and 4100 deaths in 2015. Squamous cell carcinoma is the most common histology with the human papilloma virus (HPV) being the most common etiology. Cervical cancer can be easily prevented with pap smears, HPV testing, and hopefully the HPV vaccine. Early stage cervix cancer can be treated with surgery including now fertility sparing surgery and there are high cure rates. Local advance cervical cancer is treated with combination of chemotherapy and radiation therapy with high survival rates but there is room for improvements with advancing stage. Systemic chemotherapy can be used for treatment of both recurrent and metastatic disease, but careful attention should be paid to balancing benefit and toxicity. The key to success will be the transportation of success seen in the developing countries to success in areas of the world where advanced‐stage invasive cervical cancer is most common.

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Uterine body invasion of carcinoma of the uterine cervix as seen from surgical specimens

Cited by 42 publications

References 11 publications

FDG‐PET in carcinoma of the uterine cervix with endometrial extension

FDG‐PET in carcinoma of the uterine cervix with endometrial extension

Nicotine Abuse as a Prognostic Factor in Stage Ib Cervical Carcinoma

Neoplasms of the Cervix

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