FDG‐PET in carcinoma of the uterine cervix with endometrial extension

Abstract

BACKGROUNDThe authors wished to determine whether pretreatment pathologic evidence of endometrial invasion correlated with fluorine‐18 fluorodeoxyglucose positron emission tomography (FDG‐PET) findings and outcomes in patients with carcinoma of the uterine cervix.METHODSPretreatment whole body FDG‐PET was performed in 58 patients with cervical carcinoma who also underwent pathologic evaluation of the endometrium by biopsy or dilation and curettage. FDG‐PET lymph node status, disease free survival, and overall survival were evaluated.RESULTSThirty seven (64%) patients had pathologic evidence of endometrial invasion. Pelvic lymph node metastases were three times more frequent in patients with evidence of endometrial invasion compared with those without endometrial invasion (70% vs. 23%, P < 0.001). Patients with endometrial invasion also had a significantly increased risk of paraaortic and supraclavicular lymph node metastases at presentation (30% vs. 0% P = 0.006). Endometrial invasion was associated with a decreased 2‐year disease‐free survival (78% vs. 58%, P = 0.046) and overall survival (92% vs. 65%, P =0.047).CONCLUSIONSEndometrial extension in cervical cancer correlated strongly with risk of FDG‐PET detected lymph node metastases in this study's population and was associated with a poor prognosis. Cancer 2006. © 2005 American Cancer Society.

Nonsurgical Management of Cervical Cancer: Locally Advanced, Recurrent, and Metastatic Disease, Survivorship, and Beyond

“…1). 15–20 The relapse rate in those with PET-positive node disease has been reported to be approximately 50% after standard chemoradiation. 17,21,22 Some suggest that a follow-up fludeoxyglucose (FDG)-PET scan done 3 to 4 months postchemoradiation can predict patient outcome and may help to determine the intensity of follow-up needed.…”

Sister Mary Joseph Nodule and peritoneal carcinomatosis from squamous cell cervical carcinoma

“…5 Although endometrial extension is not included in the International Federation of Gynecology and Obstetrics staging, this extension is associated with a high risk of lymph node metastases and decreased disease-free and overall survival. 6 The superficial squamous tumor replaces the entire endometrium in the intrauterine spread of cervical carcinoma. The tumor must satisfy …”

Intérêt pronostique de la TEP-TDM au 18F-FDG dans le bilan initial du cancer du col de l’utérus : étude rétrospective de 53 cas

“…Sur une population de 47 patientes en TEP seule, les auteurs ont rapporté qu'une analyse visuelle seule de la tumeur cervicale, selon des critè res prenant en compte la taille, la forme et l'hé té rogé né ité de l'hypermé tabolisme, é tait le meilleur facteur pronostique. D'autres é tudes portant sur l'atteinte ganglionnaire visuelle en TEP seule, comme par exemple celle de Hope et al en 2006 [19] ou celle de Narayan en 2009 [6], ont é té rapporté es. Malheureusement les auteurs n'ont pas pré cisé si la localisation de l'atteinte ganglionnaire é tait pelvienne ou lombo-aortique.…”