Uterine artery Doppler longitudinal changes in pregnancies complicated with intrauterine growth restriction without preeclampsia

Contro, E.; Hyun, Dong; Maggio, Irene De; Ismail, Sara; Falcone, Veronica; Gabrielli, S.; Farina, Antonio

doi:10.1002/pd.4476

Cited by 9 publications

(13 citation statements)

References 17 publications

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“…( The first trimester uterine artery Doppler (UAD) is highly predictive of both preeclampsia and FGR [5,7,9,10, II 24…”

Section: Methodsmentioning

confidence: 99%

“…While retrospective case-control studies suggest on strong associations between the UAD pulsatility index and FGR intensified with gestational age [9,10], prospective cohort studies compliment that the FGR shows associations with the uterine artery PI but no associations with the uterine artery notching (P = 0.83) [11], and that the abnormal PI and [soluble fms-like tyrosine kinase 1 (sFlt-1)]/[placental growth factor] ratio show high specificity but low sensitivity in diagnostics of preeclampsia [12,13].…”

Section: Problem Definitionmentioning

confidence: 99%

“…(1) the first trimester UAD indices are highly predictive of both preeclampsia and FGR [5,7,9,10,; (2) the first trimester UAD is highly predictive of preeclampsia and fairly predictive or not predictive of the FGR [1,2,8,; (3) the first trimester UAD has elusive or limited diagnostic accuracy in preeclampsia and FGR [3,11,12,[57][58][59][60][61][62][63][64][65][66][67][68][69][70]; and (4) the first trimester UAD indices are not predictive of preeclampsia or FGR [6,[71][72][73][74][75][76][77][78].…”

Section: Problem Definitionmentioning

confidence: 99%

“…Der stärkste prädiktive Parameter für Prä-eklampsien und FGR war der Index plazentaseitiger Gebärmutterarterien-Resistenz, wobei die höchsten Mittelwerte bei einer Mittellinienlage der Plazenta erzielt wurden (OR 0, 9).…”

Section: Zusammenfassungunclassified

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Predictive accuracy of the first trimester Doppler scan: a meta-study

Matevosyan

2015

Wien Med Wochenschr

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“…( The first trimester uterine artery Doppler (UAD) is highly predictive of both preeclampsia and FGR [5,7,9,10, II 24…”

Section: Methodsmentioning

confidence: 99%

Section: Problem Definitionmentioning

confidence: 99%

Section: Problem Definitionmentioning

confidence: 99%

Section: Zusammenfassungunclassified

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Predictive accuracy of the first trimester Doppler scan: a meta-study

Matevosyan

2015

Wien Med Wochenschr

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“…It was documented that IUGR can develop without the manifestation of preeclampsia [55]. The uterine artery pulsatility index shows a gradual increase with the gestational age in confirmed cases of IUGR without preeclampsia [56]. Also, different placental histopathological changes were observed in IUGR with preeclampsia and without preeclampsia [57].…”

Section: Pathophysiology Of Iugr and Relationship With Preeclampsia Smentioning

confidence: 95%

First trimester plasma-derived exosomal proteins: putative biomarker for early detection of pathological pregnancies

Sarker¹

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Background: Of the 130 million babies born each year, 8 million die before their first birthday. A contributing factor in many of these deaths is poor pregnancy outcome as a result of complications of pregnancy. Preeclampsia (PE) and Gestational Diabetes Mellitus (GDM) are the common pregnancy complications that have no effective antenatal treatment other than steroid administration and timely delivery. Each occurs with an incidence of 5-10% and is responsible for the majority of obstetric and paediatric morbidity and mortality. These can permanently impact on lifelong health.Early detection of disease risk and onset is the first step in implementing efficacious treatment and improving patient outcome. In the context of antenatal screening, the objective is to identify biomarkers (e.g. proteins) that are informative of the risk of asymptomatic pregnant women subsequently developing complications of pregnancy. Recent studies highlight the putative utility of tissue-specific nanovesicles (i.e. exosomes) in the diagnosis of disease onset and treatment monitoring. It was hypothesized that presymptomatic women who subsequently develop pregnancy complications display altered exosome profile (i.e. concentration and/or protein content) at first trimester of pregnancy (i.e. 6-12 weeks). The general aim of this thesis was to identify blood-borne biomarkers (i.e. exosomes) that may be used at the first antenatal visit to identify presymptomatic women who are at risk of developing complications of pregnancy. Methods:A time-series experimental design was used to establish pregnancy-associated changes in maternal plasma exosome concentrations during first trimester. Serial samples of plasma were collected from normal healthy pregnant women (n=10) at 6, 7, 8, 9, 10, 11 and 12 weeks of gestation. Plasma samples from pregnant women at 11-14 weeks of gestation who developed preeclampsia (n=15) and gestational diabetes mellitus (n=7) were also collected. Exosomes were isolated by differential and buoyant density centrifugation and characterised by size distribution and morphology using nanoparticles tracking analysis (NTA; NanoSight™) and transmission electron microscopy (TEM) respectively. The total number of exosome vesicles and placenta-derived exosome vesicles were determined by quantifying immunoreactive exosomal CD63 and a placentaspecific marker (PLAP) by ELISA. Finally, the differentially expressed exosomal proteins and peptides were identified by Liquid Chromatography and Mass Spectrometry based approaches (LC-MS/MS). Statistical analysis was performed using the Graph Pad Prism software.ii Results: EM and NTA identified the presence of 50 -120 nm spherical vesicles in maternal plasma as early as 6 weeks of pregnancy. The number of exosomes in maternal circulation increased significantly (ANOVA, p=0.002) with the progression of pregnancy (from 6 to 12 weeks). The concentration of placenta-derived exosomes in maternal plasma (i.e. PLAP + ) increased progressively with gestational age, from 6 weeks 70.6 ± 5.7 pg/ml t...

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Changes in uterine artery Doppler velocimetry and circulating angiogenic factors in the first half of pregnancies delivering a small‐for‐gestational‐age neonate

Triunfo

Crovetto

Rodrı́guez-Sureda

et al. 2017

Ultrasound in Obstet & Gyne

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Uterine artery Doppler longitudinal changes in pregnancies complicated with intrauterine growth restriction without preeclampsia

Abstract: We presented a reliable multivariable statistical model to evaluate the temporal changes of UtA-PI values as a function of both gestational age and IUGR.

Cited by 9 publications

References 17 publications

Predictive accuracy of the first trimester Doppler scan: a meta-study

Predictive accuracy of the first trimester Doppler scan: a meta-study

First trimester plasma-derived exosomal proteins: putative biomarker for early detection of pathological pregnancies

Changes in uterine artery Doppler velocimetry and circulating angiogenic factors in the first half of pregnancies delivering a small‐for‐gestational‐age neonate

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