Uterine artery Doppler and mid-trimester maternal plasma homocysteine in subsequent pre-eclampsia

Yu, Christina; Lakasing, Lorin; Papageorghiou, A.T.; Spencer, Kevin; Nicolaides, Kypros H.

doi:10.1080/jmf.16.2.134.139

Cited by 18 publications

(11 citation statements)

References 20 publications

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“…In contrast, other studies detected no differences in midtrimester maternal circulating level of homocysteine between women who developed preeclampsia and normal pregnant women 15,[18][19][20] .…”

Section: Discussionmentioning

confidence: 55%

Circulating levels of homocysteine in preeclamptic women

Khosrowbeygi

Ahmadvand

2011

Bangladesh Med Res Counc Bull

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It has been hypothesized that maternal hyperhomocysteinemia to be associated with preeclampsia. The aims of the present study were to examine maternal serum levels of total homocysteine in preeclamptic women and its association with the severity of the disease. The study population consisted of 30 preeclamptic patients and 30 matched healthy pregnant women. Serum levels of total homocysteine were assessed using enzyme immunoassay method. Maternal serum levels of total homocysteine were significantly higher in preeclamptic group than in normal pregnant women. Women with severe preeclampsia had higher serum levels of total homocysteine than mild preeclamptic patients. Levels of total homocysteine correlated positively with systolic blood pressure values in preeclamptic women. In summary, maternal serum levels of total homocysteine were increased in preeclamptic women and hyperhomocysteinemia was associated with severity of preeclampsia.

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Section: Discussionmentioning

confidence: 55%

Circulating levels of homocysteine in preeclamptic women

Khosrowbeygi

Ahmadvand

2011

Bangladesh Med Res Counc Bull

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“…This relationship has been shown in early pregnancy (Cotter et al 2001), in the second trimester (Sorensen et al 1999;Hogg et al 2000), and in the third trimester of pregnancy (Sanchez et al 2001). However, it has been suggested that midtrimester plasma homocysteine concentrations in asymptomatic women are not predictive of the subsequent development of preeclampsia (Hietala et al 2001;Raijmakers et al 2001;D'Anna et al 2004;Yu et al 2004).…”

Section: Discussionmentioning

confidence: 96%

Elevated Plasma Homocysteine Concentrations in Severe Preeclampsia and Eclampsia

İngeç

Borekci

Kadanali

2005

Tohoku J. Exp. Med.

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INGEC, M., BOREKCI, B. and KADANALI, S. Elevated Plasma Homocysteine Concentrations in Severe Preeclampsia and Eclampsia. Tohoku J. Exp. Med., 2005, 206 (3), 225-231 Homocysteine is an essential amino acid required for the growth of cells and tissues in the human body. Maternal hyperhomocysteinemia is associated with a number of placenta-mediated diseases such as preeclampsia. The aim of this study was to evaluate the plasma level of homocysteine and its association with severity of preeclampsia. A case-control study was performed with 32 mild preeclamptic patients, 25 severe preeclamptic patients, 16 eclamptic patients and 34 controls. Maternal plasma homocysteine concentration was measured prospectively at antenatal period by high-performance liquid chromatography. There were no significant differences in demographic characteristics between the study and control groups. Mean plasma levels of homocysteine in women with severe preeclampsia (16.7 ± 10.1 μ mol/l, mean ± S.D., n = 25) and eclampsia (16.5 ± 9.6 μ mol/l, mean ± S.D., n = 16) were significantly higher than those in mild preeclampsia (7.7 ± 2.4 μ mol/l, mean ± S.D., n = 32) and controls (6.7 ± 1.6 μ mol/l, mean ± S.D., n = 34) (p < 0.0001). It should be noted that plasma levels of homocysteine are not significantly different between mild preeclampsia and controls. In conclusion, plasma homocysteine concentrations are increased in severe preeclampsia and eclampsia, but not in mild preeclampsia.

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“…Earlier, a case-control study reported increased homocysteine levels at early midtrimester in women with subsequent severe and non-severe pre-eclampsia (Cotter et al, 2003). In contrast, other studies detected no difference in midtrimester homocysteine serum levels between women who developed pre-eclampsia and controls (Yu et al, 2004;Onalan et al, 2006;D'Anna et al, 2004). The contradictory results undermine the potential of homocysteine as a marker for subsequent pre-eclampsia.…”

Section: Homocysteinementioning

confidence: 87%