Uterine Anomalies

Freedman, Martin

doi:10.1055/s-2007-1022483

Cited by 7 publications

(4 citation statements)

References 64 publications

(95 reference statements)

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“…Although congenitally malformed Type II‐A‐1‐b uteri are, by definition, abnormal non‐communicating dual‐chambered uteri, the fallopian tubes of such uteri are not typically affected as a result of the derangement of the midline fusion and resorption of the mullerian ducts that occurs early in fetal development 22 . Thus, there is no reason to suspect that the results of this study are limited in scope to such dual‐chambered uteri, and the transmigration results that have been found in this study can be generalised to other types of uteri, including the normal single‐chambered variety that is possessed by >99% of women in the general population 23 .…”

Section: Discussionmentioning

confidence: 99%

“…In order to answer how often gametes transmigrate across the peritoneal cavity spontaneously in humans, a natural model of intrauterine ectopic pregnancy involving non‐communicating rudimentary uterine horns was chosen for investigation. In women with such congenital uterine malformations, there is a failure of midline fusion of the mullerian ducts early in embryologic development that results in the presence of two separate uterine cavities, only one of which has connection to a single cervix and vagina 21,22 . A diagram of such a congenital type II‐A‐1‐b uterine anomaly is shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

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Preventing ectopic pregnancies: how often does transperitoneal transmigration of sperm occur in effecting human pregnancy?

Nahum

Stanislaw

McMahon

2004

BJOG

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a Objective Transperitoneal transmigration of sperm constitutes the mechanism by which ectopic pregnancies occur in unilaterally obstructed fallopian tubes. This study was undertaken to determine how often sperm transmigrate across the peritoneal cavity to effect human pregnancy. Design In women with non-communicating rudimentary uterine horn pregnancies, the ratio of total uterine horn pregnancies to prior contralateral hemi-uterine pregnancies was calculated to infer the overall transperitoneal sperm transmigration rate. The prior parity frequency distribution was also determined to calculate the best-fit per-pregnancy probability of attaining a rudimentary horn pregnancy with each subsequent gestation using maximum likelihood estimation. Setting 20th century.Sample Non-communicating rudimentary uterine horn pregnancies reported from 40 countries.Methods Two hundred and seventy-two cases were identified using manual and computerised searches of Index Medicus, Excerpta Medica, the Index-Catalogue of the Library of the Surgeon-General's Office and standard reference tracing. Main outcome measures The ratio of total prior non-rudimentary uterine horn pregnancies to rudimentary uterine horn pregnancies and the frequency distribution of prior maternal parities. Results Prior to the incident 272 uterine horn pregnancies, the number of observed pregnancies was 292 (ratio ¼ 0.93), implying an aggregate sperm transmigration rate of 0.48. Using the prior parity frequency distribution, the best-fit probability of attaining a rudimentary horn gestation per-pregnancy was 0.51 (95% CI 0.48 -0.56). Conclusions Intraperitoneal sperm transmigration occurs approximately half the time in effecting spontaneous human pregnancies. To minimise the risk of ectopic tubal pregnancy in woman with unilaterally damaged fallopian tubes, salpingectomy should be the preferred surgical treatment, rather than attempting tubal salvage and repair.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preventing ectopic pregnancies: how often does transperitoneal transmigration of sperm occur in effecting human pregnancy?

Nahum

Stanislaw

McMahon

2004

BJOG

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“…This is consistent with the lower incidence of preeclampsia observed among women with recurrent abortions. These women might be expected to have a higher blocking activity as a consequence of repeated stimulation by fetal antigens [15], The genital tract is related embryologically to the for mation of the urinary tract [10]. The normal growth of the mullerian (paramesonephric) ducts depends on the development of the wolfian (mesonephric) ducts, fore runners of the urinary system [5].…”

Section: Discussionmentioning

confidence: 99%

The Association of Pregnancy-Induced Hypertension and Uterine Malformations

Ben‐Rafael

Seidman

Recabi

et al. 1990

Gynecol Obstet Invest

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To evaluate the incidence of pregnancy-induced hypertension (PIH) in women with congenital uterine malformations, we examined the pregnancy complications of 67 women with uterine anomalies demonstrated by hysterosalpingography (HSG). The study group was compared with a control group of 130 women with normal-shaped uterus proven by HSG – matched for age, parity and presenting complaint. A significantly increased (p < 0.04) rate of PIH was found for women with uterine malformation as well as a 2-fold higher frequency of preeclampsia. The etiology for this association is unknown, however; it is suggested that uterine malformation is a predisposing condition to PIH.

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“…On occasion a longitudinal vaginal septum will also be present. In rare cases cervical duplication may be seen in conjunction with complete uterine and vaginal septa, often confounding attempts at clinical diagnosis [5][6][7] .…”

Section: Embryological Development Of the Uterusmentioning

confidence: 99%