Background:Seroma and hematoma formations are the most common complications after plastic
surgery. The aim of this study was to assess the efficacy of autologous
platelet-rich plasma (A-PRP) glue to reduce postoperative wound complications and
improve surgical outcomes.Methods:Fifty-four patients were included in this study. They underwent breast reduction
surgery, abdominoplasty, or limb lifting with A-PRP glue application on the entire
surface of the subcutaneous tissue at the time of suture. Retrospective data were
used for the control group. The primary endpoint was the incidence of
postoperative seroma or hematoma. The secondary endpoint was the Patient and
Observer Scar Assessment Scale score.Results:Demographics and clinical characteristics were not statistically different between
the A-PRP glue group and the control group regarding age, sex ratio, and body mass
index. After abdominoplasty, 37.5% of patients (3/8) in the control group
experienced seroma and hematoma complications versus 12.5% of patients (2/16) in
the A-PRP glue group (P = 0.55 and P = 0.25,
respectively). After limb lifting, 50% of patients experienced postoperative
complications in the control group versus no patient in the A-PRP glue group
(P = 0.03*; * indicates that the
P value is significant). After breast reduction, no patient
experienced complication in the A-PRP glue group versus 25% of patients in the
control group who experienced hematoma (P = 0.04*). The
scar quality assessed 12 months after surgery showed no statistical differences
between the groups.Conclusions:A-PRP glue seems effective to prevent seroma formation after limb lifting and
hematoma formation after breast reduction. Wound-healing quality did not seem to
be improved.