Usnic acid-loaded polyaniline/polyurethane foam wound dressing: preparation and bactericidal activity

Santos, Marcelo R. dos; Alcaraz-Espinoza, José J.; Costa, Mateus Matiuzzi da; Oliveira, Helinando Pequeno de

doi:10.1016/j.msec.2018.03.019

Cited by 45 publications

(26 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6, the comparison of inhibition haloes for different colonies revealed that, in both cases (against E. coli and S. aureus), the C. procera disk returned negligible inhibitory activity, while PANI-coated fibers and pure PANI showed a clear inhibitory figure against both E. coli (inhibition halo of 20 and 23 mm, respectively) and S. aureus (inhibition halo of 24 and 25 mm, respectively), confirming the improved diffusion on agar is observed for the PANI-CP sample against S. aureus. These data confirm the antibacterial activity of doped PANI (emeraldine salt) [2], and the high inhibition halo values suggest that the release of diffusion species can cause potential disruption of the cell wall, favoring the antibacterial activity of the resulting material. By comparison with PANI-CP samples, a slight variation has been observed for the inhibition halos measured for pure PANI (24 and 25 mm, respectively).…”

Section: Antibacterial Activity Of Pristine and Chemically Modified Fsupporting

confidence: 69%

“…The synthesis of PANI followed the general steps described in Ref. [2] with some modifications: C. procera fibers were freshly washed with Milli-Q water and dried at 50 °C for 6 h. In the following step, 150 μL of aniline monomers was dissolved in hydrochloric acid (50 mL at 1.0 M). Fibers of C. procera (1 g) were then incorporated into the solution, which was kept under continuous stirring in an ice bath.…”

Section: Preparation Of Pani-coated C Procera (Pani-cp) Hollow Tubesmentioning

confidence: 99%

“…In addition, the scarcity of new effective antibiotics reinforces the need for strategies in the development of alternative antibacterial agents. In particular, the use of conducting polymers [2][3][4] as antibacterial agents has been considered a promising strategy. In general, the production of structures with large surface area and a well-defined morphology plays a critical role in the performance of hierarchical devices.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polyaniline-coated Calotropis procera L. hollow tubular fibers with remarkable antibacterial activity

et al. 2020

Self Cite

View full text Add to dashboard Cite

The development of environmentally friendly prototypes for use as antibacterial agents and as alternatives to antibiotics is a necessary step toward the control of infections. With this in mind, the production of hybrid composites based on natural and synthetic materials has been successfully explored. Herein, the chemical polymerization of polyaniline on natural fibers of Calotropis procera was used to explore the combined available surface area of fibers with the intrinsic properties of the conductive layer of PANI. What resulted was a coating of conducting polymer on natural fibers with strong antibacterial activity against Staphylococcus aureus and Escherichia coli. The characteristic time for the complete elimination of colonies (kill time) observed in assays was in the region of 3-4 h of treatment, with an inhibition halo of 20 mm (against E. coli) and 24 mm (against S. aureus). In addition to the antibacterial activity against S. aureus and E. coli, the modified fibers exhibited antibiofilm activity against S. aureus, which was evidenced in the reduction in the degree of bacterial adhesion to the surface applied in treatment (with a 39.96% biofilm inhibition). The proposed method represents a simple, low-cost, and one-step method for the modification of natural fibers with relevant applications in antibacterial agents.

show abstract

Section: Antibacterial Activity Of Pristine and Chemically Modified Fsupporting

confidence: 69%

Section: Preparation Of Pani-coated C Procera (Pani-cp) Hollow Tubesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Polyaniline-coated Calotropis procera L. hollow tubular fibers with remarkable antibacterial activity

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Foam dressings provide thermal insulation and maintain moisture to the wound, and prevent damage to the wound at the time of removal. These dressings may also be used as secondary dressings with hydrogel or alginate dressings, in conjunction with a topical antimicrobial agent for infected wounds (Davies et al, 2017)Moreover, polyaniline/polyurethane foam dressing carried an anti-biofilm lichen metabolite usnic acid indicated an improved antibiofilm activity of conducting polymer (dos Santos et al, 2018).…”

Section: Wound Dressingsmentioning

confidence: 99%

Selection of Appropriate Wound Dressing for Various Wounds

Shi

Wang

et al. 2020

Front. Bioeng. Biotechnol.

298

157

View full text Add to dashboard Cite

There are many factors involved in wound healing, and the healing process is not static. The therapeutic effect of modern wound dressings in the clinical management of wounds is documented. However, there are few reports regarding the reasonable selection of dressings for certain types of wounds in the clinic. In this article, we retrospect the history of wound dressing development and the classification of modern wound dressings. In addition, the pros and cons of mainstream modern wound dressings for the healing of different wounds, such as diabetic foot ulcers, pressure ulcers, burns and scalds, and chronic leg ulcers, as well as the physiological mechanisms involved in wound healing are summarized. This article provides a clinical guideline for selecting suitable wound dressings according to the types of wounds.

show abstract

“…A number of polymer-based DDSs have been devised for delivering usnic acid [25][26][27][28][29]. However, this review will focus only on the polymeric nano-and microcarriers (i.e., micro and nanospheres (matrix and capsules), as well as nonspherical nanoparticles (nanofibers)) as systems developed with the aim of achieving maximum tissue compatibility and minimal cytotoxicity [13,30].…”

Section: Polymeric Nano-and Microcarriersmentioning

confidence: 99%

Nano- and Microcarriers as Drug Delivery Systems for Usnic Acid: Review of Literature

2020

View full text Add to dashboard Cite

Usnic acid is one of the most investigated lichen secondary metabolites, with several proven biological properties with potential medical relevance. However, its unfavorable physico-chemical properties, as well as observed hepatotoxicity, have discouraged wide-range utilization of usnic acid as a promising therapeutic agent. In accordance with the growing research interest in the development of nanotechnology, especially in the arena of preparations based on natural sources of medicinal compounds, usnic acid incorporated into nano- and microsized colloidal carriers has been a subject of a large number of publications. Therefore, this review discusses the overall results of the studies dealing with usnic acid encapsulated into lipid-based, polymeric and nonorganic micro- and/or nanocarriers, as potential drug delivery systems for this natural compound, in an attempt to introduce its usage as a potential antitumor, antimicrobial, wound-healing, antioxidative and anti-inflammatory drug.

show abstract

Usnic acid-loaded polyaniline/polyurethane foam wound dressing: preparation and bactericidal activity

Cited by 45 publications

References 66 publications

Polyaniline-coated Calotropis procera L. hollow tubular fibers with remarkable antibacterial activity

Polyaniline-coated Calotropis procera L. hollow tubular fibers with remarkable antibacterial activity

Selection of Appropriate Wound Dressing for Various Wounds

Nano- and Microcarriers as Drug Delivery Systems for Usnic Acid: Review of Literature

Contact Info

Product

Resources

About