Using the venous angle as a pressure reservoir to retrogradely fill the subclavian lymphatic trunk with contrast agent for lymphatic mapping

Stouthandel, Michael E. J.; Debbaut, Charlotte; Deviche, Jurgen; Truyens, Bart; Veldeman, Liv; Hoof, Tom Van

doi:10.1016/j.aanat.2020.151562

Cited by 2 publications

(4 citation statements)

References 29 publications

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“…Based on previous experiments, a proof of concept for retrograde lymphatic filling was provided [72,77]. However, many variables play a role in this process and a combination of adaptations to the current experimental approaches is still required to optimise the retrograde filling methodology.…”

Section: Discussionmentioning

confidence: 99%

Section: Techniques To Characterise Breast Lymphatic Anatomymentioning

confidence: 99%

“…The lymphatic valves withstood pressures of up to 55 mmHg, while no such pressures were tolerated by the lymphatic walls or the venous walls. Therefore, even though a proof of concept was provided for retrograde lymphatic injections, the experimental set up needed to be optimised further to allow a significant amount of retrograde filling of the subclavian lymphatic trunk [77]. From the previous studies it became clear that retrograde filling of the lymphatics was in fact possible, yet it would require technical adaptations and additional experiments to optimise the experimental procedure.…”

Section: Techniques To Characterise Breast Lymphatic Anatomymentioning

confidence: 99%

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The Lymphatic System in Breast Cancer: Anatomical and Molecular Approaches

et al. 2021

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Breast cancer is one of the most important causes of premature mortality among women and it is one of the most frequently diagnosed tumours worldwide. For this reason, routine screening for prevention and early diagnosis is important for the quality of life of patients. Breast cancer cells can enter blood and lymphatic capillaries, then metastasizing to the regional lymph nodes in the axilla and to both visceral and non-visceral sites. Rather than at the primary site, they seem to enter the systemic circulation mainly through the sentinel lymph node and the biopsy of this indicator can influence the axillary dissection during the surgical approach to the pathology. Furthermore, secondary lymphoedema is another important issue for women following breast cancer surgical treatment or radiotherapy. Considering these fundamental aspects, the present article aims to describe new methodological approaches to assess the anatomy of the lymphatic network in the axillary region, as well as the molecular and physiological control of lymphatic vessel function, in order to understand how the lymphatic system contributes to breast cancer disease. Due to their clinical implications, the understanding of the molecular mechanisms governing lymph node metastasis in breast cancer are also examined. Beyond the investigation of breast lymphatic networks and lymphatic molecular mechanisms, the discovery of new effective anti-lymphangiogenic drugs for future clinical settings appears essential to support any future development in the treatment of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Techniques To Characterise Breast Lymphatic Anatomymentioning

confidence: 99%

Section: Techniques To Characterise Breast Lymphatic Anatomymentioning

confidence: 99%

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The Lymphatic System in Breast Cancer: Anatomical and Molecular Approaches

et al. 2021

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“…Like the ESTRO and PROCAB guidelines, our PCP specific guidelines are primarily based on the vasculature, because the lymphatics are located in close proximity to the veins 13,14,21 . Vessel based guidelines are less patient and position dependent, compared to bony landmarks as reference points 13,14,17 .…”

Section: Discussionmentioning

confidence: 99%

Delineation guidelines for the lymphatic target volumes in ‘prone crawl’ radiotherapy treatment position for breast cancer patients

Stouthandel

Kayser

Vakaet

et al. 2021

Sci Rep

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Our recently developed prone crawl position (PCP) for radiotherapy of breast cancer patients with lymphatic involvement showed promising preliminary data and it is being optimized for clinical use. An important aspect in this process is making new, position specific delineation guidelines to ensure delineation (for treatment planning) is uniform across different centers. The existing ESTRO and PROCAB guidelines for supine position (SP) were adapted for PCP. Nine volunteers were MRI scanned in both SP and PCP. Lymph node regions were delineated in SP using the existing ESTRO and PROCAB guidelines and were then translated to PCP, based on the observed changes in reference structure position. Nine PCP patient CT scans were used to verify if the new reference structures were consistently identified and easily applicable on different patient CT scans. Based on these data, a team of specialists in anatomy, CT- and MRI radiology and radiation oncology postulated the final guidelines. By taking the ESTRO and PROCAB guidelines for SP into account and by using a relatively big number of datasets, these new PCP specific guidelines incorporate anatomical variability between patients. The guidelines are easily and consistently applicable, even for people with limited previous experience with delineations in PCP.

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Using the venous angle as a pressure reservoir to retrogradely fill the subclavian lymphatic trunk with contrast agent for lymphatic mapping

Cited by 2 publications

References 29 publications

The Lymphatic System in Breast Cancer: Anatomical and Molecular Approaches

The Lymphatic System in Breast Cancer: Anatomical and Molecular Approaches

Delineation guidelines for the lymphatic target volumes in ‘prone crawl’ radiotherapy treatment position for breast cancer patients

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