Using the power of organic synthesis for engineering the interactions of nanoparticles with biological systems

Mizuhara, Tsukasa; Moyano, Daniel F.; Rotello, Vincent M.

doi:10.1016/j.nantod.2015.11.002

Cited by 28 publications

(27 citation statements)

References 77 publications

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“…The surface functionality of NPs controls the protein corona composition and dictates interactions with target cells [41,[43][44][45]. For example, it has been demonstrated that surface modifications of alkyne-terminated thermally hydrocarbonized porous silicon NPs with dextran reduces the percentage of immune proteins (e.g., fibrinogen and immunoglobulin G) in the protein corona [46].…”

Section: Surface Functionality Directs Protein Corona Profilementioning

confidence: 99%

Emerging understanding of the protein corona at the nano-bio interfaces

2016

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Upon entering the physiological environment, nanoparticles (NPs) are immediately surrounded by a complex and tightly bound layer of biomolecules, or '(hard) protein corona'. The corona controls NP fate in vivo and becomes the interface with cells. One of nanomedicine's central goals is to make NPs capable of active targeting in both imaging and therapy. If the NP is not designed correctly, the resulting corona can cause mistargeting and aberrant biodistribution, unanticipated toxicity, and low therapeutic efficacy. Here we present groundbreaking concepts about nanobio interactions and discuss approaches to bypass protein corona issues and thus enhance the efficacy of NPs.

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Section: Surface Functionality Directs Protein Corona Profilementioning

confidence: 99%

Emerging understanding of the protein corona at the nano-bio interfaces

2016

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“…Broadly speaking, nano-scale objects are recognized and actively internalized by cells (i.e., cells expend their energy), subsequently following intracellular routes originally intended to carry biomolecules for messaging and other processes 1 . Consequently, much effort has been directed towards functionalizing the nanoparticle surface to control the organism and intracellular fate 10 11 12 . For instance, for genetic medicines intracellular delivery to the nucleus is a key aim.…”

mentioning

confidence: 99%

Spatial and Structural Metrics for Living Cells Inspired by Statistical Mechanics

Åberg

Varela

Fitzpatrick

et al. 2016

Sci Rep

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Experimental observations in cell biology have advanced to a stage where theory could play a larger role, much as it has done in the physical sciences. Possibly the lack of a common framework within which experimentalists, computational scientists and theorists could equally contribute has hindered this development, for the worse of both disciplines. Here we demonstrate the usage of tools and concepts from statistical mechanics to describe processes inside living cells based on experimental data, suggesting that future theoretical/computational models may be based on such concepts. To illustrate the ideas, we describe the organisation of subcellular structures within the cell in terms of (density) pair correlation functions, and subsequently use the same concepts to follow nano-sized objects being transported inside the cell. Finally, we quantify an interesting subcellular re-organisation, not previously discerned by molecular biology methods.

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“…We have plenty to work on just taking our systems where they need to go, be it in vivo or in the clinic [ 97 – 98 ]. Broader picture, what I really want to see is the integration of the synthetic and biological worlds to generate new systems that can do things that neither can do alone [ 99 – 100 ]. This vision of "cyborg" constructs with emergent behavior is motivating both my own research and my editorial efforts with Bioconjugate Chemistry .…”

Section: Reviewmentioning

confidence: 99%