Using the NIH Toolbox Cognition Battery (NIHTB-CB) in individuals with traumatic brain injury.

Tulsky, David S.; Carlozzi, Noelle E.; Holdnack, James A.; Heaton, Robert K.; Wong, Alex; Goldsmith, Arielle; Heinemann, Allen W.

doi:10.1037/rep0000174

Cited by 52 publications

(48 citation statements)

References 62 publications

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“…For individuals with acquired brain injury, the Crystallized Cognition Composite Score can serve as an estimate of pre-injury general cognitive ability. This composite correlates strongly with other known “hold” tests (Gershon et al, 2014) and is resistant to the effects of TBI (Tulsky et al, under review). The fluid cognition tests are List Sorting Working Memory, Picture Sequence Memory, Pattern Comparison Processing Speed, Flanker Inhibitory Control and Attention Test (measuring both attention and executive functioning), and the Dimensional Change Card Sort Test.…”

Section: Methodsmentioning

confidence: 63%

“…This study provides validity evidence for the NIHTB-CB in TBI. Another study involving the same samples reported significant group differences between people with and without TBI, and illustrated that performance on the NIHTB-CB is associated with injury severity (Tulsky et al, under review). The present study adds two important findings.…”

Section: Discussionmentioning

confidence: 96%

“…These are the same clinical samples as used in a broader study relating to the NIHTB-CB following TBI (Tulsky et al, under review). They were recruited at three rehabilitation centers: Rehabilitation Institute of Chicago (Northwestern University), Washington University, and the University of Michigan.…”

Section: Methodsmentioning

confidence: 99%

“…If no GCS was available, TBI cases were classified based on the detailed description of their injury and confirmed by a neuropsychologist on staff independent of performance on the NIHTB-CB or traditional neurocognitive tests. See Figure 1 in Tulsky et al (under review) for more information regarding the review of medical records and the classification of TBI severity.…”

Section: Methodsmentioning

confidence: 99%

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NIH toolbox cognition tests following traumatic brain injury: Frequency of low scores.

Holdnack¹,

Silverberg²,

Tulsky³

et al. 2017

Rehabilitation Psychology

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Purpose/Objective To apply multivariate base rate analyses to the National Institutes of Health Toolbox Cognition Battery (NIHTB-CB) to facilitate the identification of cognitive impairment in individuals with traumatic brain injury (TBI). Research Method/Design In a multisite cross-sectional design, 158 participants who sustained a complicated mild or moderate TBI (n=74) or severe TBI (n=84) at least one year earlier were administered the NIHTB-CB. The NIHTB-CB is comprised of two crystallized cognition tests (reflecting premorbid ability) and five fluid cognition tests, measuring processing speed, memory, and executive functioning. Base rates for obtaining 0 to 5 low fluid cognition scores were calculated across a range of cutoffs for defining a low test score (≤25th to 5th percentiles). Base rates of low scores in the TBI sample were compared to the NIHTB-CB normative sample using diagnostic accuracy statistics. Results The proportion of the TBI sample obtaining low scores decreased as the cutoff for defining a low score decreased. Individuals with lower premorbid cognitive ability, as measured by NIHTB-CB crystallized composite score, tended to produce more low scores on the NIHTB-CB fluid cognition tests, even when using fully demographically-adjusted scores. Certain patterns of low scores were associated with TBI (defined as Likelihood Ratio>2.0), whereas others were non-specific, occurring almost as often in participants without TBI. Conclusions/Implications Premorbid ability stratified base rate tables provided in this article can guide researchers and clinicians in the interpretation of NIHTB-CB performance in adults with TBI.

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Section: Methodsmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

NIH toolbox cognition tests following traumatic brain injury: Frequency of low scores.

Holdnack¹,

Silverberg²,

Tulsky³

et al. 2017

Rehabilitation Psychology

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“…Four tests were chosen were used as a brief neuropsychological tests battery to assess memory and speed functions. NIH Toolbox tests have excellent reliability and validity as reported by Tulsky et al (2017). Before the 2016 season, the Toolbox testing platform was changed from a desk-top computer to an iPad.…”

Section: Nih Toolboxmentioning

confidence: 99%

Psychometric properties of the standardized assessment of concussion in youth football: Validity, reliability, and demographic factors

Maerlender

Smith

Brolinson

et al. 2020

Applied Neuropsychology: Child

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The objective of this study was to determine the psychometrics (reliability, validity) of the original Standardized Assessment of Concussion (SAC) in a youth sample (ages 11 to 13). Demographic factors of race, level of vocabulary knowledge, mother's level of education were also considered. Over 150 youth football athletes completed the SAC and a brief battery of NIH Toolbox cognitive tests as part of a larger study on biomechanical factors in youth sport concussion. This was a withinsubjects design (pre-season, post-season assessments), and correlational analysis of convergent and discriminant validity. Between groups analysis based on demographic differences was also employed. The pre-season SAC scores were not different by age; however, SAC scores were statistically different by race: t(155) = 3.162, p = .002, d = .519. Maternal level of education and participant vocabulary scores were related to racial group membership. Convergent and discriminant validity were established compared to NIH Toolbox tests of memory and speed. Pre-post-season tests for 108 participants established marginally acceptable test-retest reliability (ICC = .692). These data support the use of the original SAC in youth football although clinicians must be aware of racial differences in scores.

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Associations between NIH Toolbox Cognition Battery and in vivo brain amyloid and tau pathology in non‐demented older adults

Snitz

Tudorascu

et al. 2020

Alzheimer's & Dementia: Diagnosis, Assessment &

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Introduction The National Institutes of Health (NIH) Toolbox Cognition Battery (NIHTB‐CB) was developed to be a common assessment metric across a broad array of research studies. We investigated associations between NIHTB‐CB and brain amyloid and tau deposition in cognitively unimpaired older adults. Methods One hundred eighteen community‐based volunteers completed magnetic resonance imaging (MRI), Pittsburgh compound B (PiB)‐PET (positron emission tomography) and AV‐1451‐PET neuroimaging, a neuropsychological evaluation, NIHTB‐CB, and the Clinical Dementia Rating (CDR) scale. Demographically adjusted regression models evaluated cognition–biomarker associations; standardized effect sizes allowed comparison of association strength across measures. Results No NIHTB‐CB measures were associated with amyloid deposition. NIHTB‐CB measures of fluid cognition, including Pattern Comparison Processing Speed, Dimensional Change Card Sort, and Fluid Cognition Composite, were associated with tau deposition in higher Braak regions. Pattern Comparison Processing Speed was the most robust association with sensitivity analyses. Discussion NIHTB‐CB tasks of processing speed and executive functions may be sensitive to pathologic tau deposition on imaging in normal aging.

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Using the NIH Toolbox Cognition Battery (NIHTB-CB) in individuals with traumatic brain injury.

Abstract: Findings provide evidence of construct validity and the clinical utility of the NIHTB-CB in individuals with TBI. (PsycINFO Database Record

Cited by 52 publications

References 62 publications

NIH toolbox cognition tests following traumatic brain injury: Frequency of low scores.

NIH toolbox cognition tests following traumatic brain injury: Frequency of low scores.

Psychometric properties of the standardized assessment of concussion in youth football: Validity, reliability, and demographic factors

Associations between NIH Toolbox Cognition Battery and in vivo brain amyloid and tau pathology in non‐demented older adults

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