Using the method of biotesting to assess the toxicity of waste medical and biological practices containing nanomaterials

Abstract

One of the current modern scientific directions is the research and introduction of products obtained using nanotechnologies into various spheres of human activity. Among the variety of nanostructures, metal nanoparticles are found to be the most widely used, which, due to the uniqueness of their properties and small size, are considered as the most promising agents in the composition of bactericidal agents. They are used as specific carriers of drugs and as components in the composition of antibacterial agents. In addition, it has been proven that the bacteriolytic and bacteriostatic properties of some metals are greatly enhanced with decreasing size. Nanoparticles of various metals, among which silver nanoparticles are the most widely used, can be used independently; however, their high ability to aggregate requires the choice of stabilizers, which usually use natural and synthetic polymers. However, their use is limited due to the high toxicity of metallic nanoparticles. Therefore, the search for the safest options for metal nanoparticles is relevant. This article presents data on the toxicity study of prototypes of silver nanoparticles stabilized by synthetic and natural polymers on biological test objects.

Antimicrobial activity of aqueous dispersions of silver nanoparticles against pathogens of purulent-inflammatory diseases

“…Наночастицы серебра, стабилизированные додецилсульфатом натрия, показали высокую эффективность в отношении исследуемых грамположительных и грамотрицательных бактерий, что, возможно, обусловлено высокой степенью токсичности полимера, данные по которой были получены ранее на биотест-объектах при проведении биотестирования и культурах клеток млекопитающих. Остальные природные и синтетические полимерные стабилизаторы, используемые в работе, по показателям острой токсичности были отнесены к малоопасным соединениям [32,34].…”