Using skin impedance to improve prediction accuracy of continuous glucose monitoring system

Yu, Haixia; Liu, Jin; Shi, Ting; Li, Dachao; Du, Zhenhui

doi:10.1117/12.762154

Cited by 9 publications

(5 citation statements)

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“…To simplify the analysis, the skin was treated as a pure resistance model. The structure of the three-electrode sensor was shown in Figure 1 ( E A , E B , and E C are electrodes A, B, and C, respectively) [ 16 ]. The area of skin to be measured was under electrode B. R A , R B , and R C were the longitudinal resistances of the epidermis under electrodes A, B, and C, respectively; R 1 and R 2 were the resistances of the tissue under the epidermis between electrodes B and C and between electrodes A and B, respectively.…”

Section: Design Of the Three-electrode Sensor For Skin Resistance Meamentioning

confidence: 99%

A Method for Measuring the Volume of Transdermally Extracted Interstitial Fluid by a Three-Electrode Skin Resistance Sensor

Wang

et al. 2014

Sensors

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It is difficult to accurately measure the volume of transdermally extracted interstitial fluid (ISF), which is important for improving blood glucose prediction accuracy. Skin resistance, which is a good indicator of skin permeability, can be used to determine the volume of extracted ISF. However, it is a challenge to realize in vivo longitudinal skin resistance measurements of microareas. In this study, a three-electrode sensor was presented for measuring single-point skin resistance in vivo, and a method for determining the volume of transdermally extracted ISF using this sensor was proposed. Skin resistance was measured under static and dynamic conditions. The correlation between the skin resistance and the permeation rate of transdermally extracted ISF was proven. The volume of transdermally extracted ISF was determined using skin resistance. Factors affecting the volume prediction accuracy of transdermally extracted ISF were discussed. This method is expected to improve the accuracy of blood glucose prediction, and is of great significance for the clinical application of minimally invasive blood glucose measurement.

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Section: Design Of the Three-electrode Sensor For Skin Resistance Meamentioning

confidence: 99%

A Method for Measuring the Volume of Transdermally Extracted Interstitial Fluid by a Three-Electrode Skin Resistance Sensor

Wang

et al. 2014

Sensors

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“…This can be effectively achieved by measuring glucose concentrations in transdermally extracted ISF samples, which have been showed to have good correlation with blood glucose concentrations [1]. Recently, MEMS technology has been used to produce miniaturized devices for transdermal ISF extraction [2] as well as glucose sensing, but there is a lack of on-chip ISF volume measurement capabilities, which are required to compensate for skin permeability variations over time [3]. The enzymatic electrochemical sensor has been commonly realized for glucose monitoring, in which electroactive chemical generation and hydrogen peroxide production may cause erosion of the sensor electrodes and deactivation of the functional enzymes [4].…”

Section: Introductionmentioning

confidence: 99%

A microfluidic system with volume sensor and dielectric glucose sensor for continuous glucose monitoring

Huang

et al. 2013

2013 Transducers &Amp; Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems

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We present a microfluidic system for interstitial fluid (ISF) transdermal extraction, ISF volume measurement, and dielectric glucose sensing towards the application of continuous glucose monitoring. This device significantly incorporates a MEMS volume sensor, which measures extracted ISF volume via conductance monitoring, and integrates a MEMS dielectric glucose sensor, which specifically measures glucose concentrations in the transdermally extracted ISF via affinity binding. The volume sensor and the glucose sensor in the microfluidic system are characterized. The feasibility of the single-chip device for automated, accurate, and continuous monitoring of subcutaneous ISF glucose concentrations is verified.

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“…This transdermal ISF extraction technique offers promise of non-invasive, continuous, and real-time glucose monitoring, but unfortunately only a minute volume of ISF is extracted and scatters on the skin surface, making it unsuitable to be collected and measured with macroscale systems. Furthermore, skin permeability varies with time, requiring precise ISF volume measurement in order to calculate the blood glucose concentration accurately [2].…”

Section: Introductionmentioning

confidence: 99%

An integrated microfluidic system for interstitial fluid transdermal extraction

Roberts

et al. 2011

2011 16th International Solid-State Sensors, Actuators and Microsystems Conference

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We present a new microfluidic system for transdermal interstitial fluid (ISF) extraction, collection, and volumetric measurement towards the application of continuous glucose monitoring. This device consists of a venturi tube, a volume sensor, pneumatic valves, and microchannels. Under the management of pneumatic valves, demonstration of the defined volume normal saline injection, ISF extraction, collection and volumetric measurement functions of the system is presented using the stable vacuum generated by the integrated venturi structure. The stability of defined volume normal saline injection is tested, and the coefficient of variation for 20 tests is 0.0041. A simulating test of ISF collection and volumetric measurement is done with the system, and the measurement results correlate well (R 2 =0.9992) with the values measured by micro syringe.

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Using skin impedance to improve prediction accuracy of continuous glucose monitoring system

Cited by 9 publications

References 0 publications

A Method for Measuring the Volume of Transdermally Extracted Interstitial Fluid by a Three-Electrode Skin Resistance Sensor

A Method for Measuring the Volume of Transdermally Extracted Interstitial Fluid by a Three-Electrode Skin Resistance Sensor

A microfluidic system with volume sensor and dielectric glucose sensor for continuous glucose monitoring

An integrated microfluidic system for interstitial fluid transdermal extraction

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