2014
DOI: 10.3390/s140407084 View full text |Buy / Rent full text
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Abstract: It is difficult to accurately measure the volume of transdermally extracted interstitial fluid (ISF), which is important for improving blood glucose prediction accuracy. Skin resistance, which is a good indicator of skin permeability, can be used to determine the volume of extracted ISF. However, it is a challenge to realize in vivo longitudinal skin resistance measurements of microareas. In this study, a three-electrode sensor was presented for measuring single-point skin resistance in vivo, and a method for … Show more

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“…Normal skin impedance was proven to be an important indicator of skin permeability (19). Therefore, normal skin impedance experiments were conducted firstly to verify the possibility of the proposed thermal activation method by a noninvasive three-electrode measurement method (20). The measurement method, setup, and data are shown in figs.…”
Section: Thermal Activation To Facilitate Isf Extractionmentioning
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“…Normal skin impedance was proven to be an important indicator of skin permeability (19). Therefore, normal skin impedance experiments were conducted firstly to verify the possibility of the proposed thermal activation method by a noninvasive three-electrode measurement method (20). The measurement method, setup, and data are shown in figs.…”
Section: Thermal Activation To Facilitate Isf Extractionmentioning
“…Under low frequency conditions (100 Hz~1000 Hz), skin impedance can better reflect its penetration. The smaller the impedance of skin becomes, the greater the penetration of skin becomes [ 11 , 12 , 13 ]. Traditionally, skin permeability evaluation, which is realized by impedance detected at a certain frequency based on macro-electrode, has the disadvantages of large measurement error, low sensitivity, and difficulty in integration [ 14 , 15 ].…”
Section: Introductionmentioning