This study aimed to screen an effective combination of treatment times for the processing of garden cress seeds (GCS) to enhance nutritional value. GCS was subjected to different combinations of pre-treatments, namely boiling (10 min), blanching (3 min), and soaking (12 hr) followed by roasting (2.5, 5 and 7.5 min), respectively which were compared with control sample for maximum mineral retention, especially calcium. It was found that treatment with SR 2.5 increased total protein and ash to 22.90% and 5.24%, respectively. BoR 7.5 treatment increased the fat content to 23.86%. The greatest calcium retention (378 mg/100 g) was observed when treating SR 7.5, as the ANF decreased from 458.3 to 414.5 mg/100 g for phytate and from 152.11 to 93.93 mg for oxalate /100 g. Therefore, treatment with SR 7.5 can be considered as the best pre-treatment to improve the nutritional value of GCS and reduce the anti-nutritional components.