Using nicotine in scalp hair to assess maternal passive exposure to tobacco smoke

Li, Zhenjiang; Li, Zhiwen; Zhang, Jingxu; Huo, Wenhua; Zhu, Yibing; Xie, Jing; Lü, Qun; Wang, Bin

doi:10.1016/j.envpol.2016.12.044

Cited by 13 publications

(4 citation statements)

References 31 publications

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“…5,6 Nicotine is an important emerging pollutant that can be found on surfaces, 7 water, 8 soil, air 9 and even in pregnant woman's hair. 10 We have previously demonstrated that maternal nicotine exposure during lactation compromises rat offspring's phenotype at long-term in a sex-dependent manner: male offspring showed, at adulthood, obesity, normophagia, despite hypothalamic leptin resistance, hyperleptinemia, hypercorticosteronemia and hypothyroidism, while female offspring had normal body mass, despite hyperphagia, unchanged leptinemia and corticosteronemia, but hyperthyroidism. [11][12][13] Several different mechanisms have been associated with endocrine dysfunctions, some of which have been linked to obesity onset.…”

Section: Introductionmentioning

confidence: 98%

Nicotine exposure during breastfeeding alters the expression of endocannabinoid system biomarkers in female but not in male offspring at adulthood

Miranda

Rodrigues

Peixoto

et al. 2023

J Dev Orig Health Dis

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Early nicotine exposure compromises offspring’s phenotype at long-term in both sexes. We hypothesize that offspring exposed to nicotine during breastfeeding show deregulated central and peripheral endocannabinoid system (ECS), compromising several aspects of their metabolism. Lactating rats received nicotine (NIC, 6 mg/Kg/day) or saline from postnatal day (PND) 2 to 16 through implanted osmotic minipumps. Offspring were analyzed at PND180. We evaluated protein expression of N-acylphosphatidylethanolamide-phospholipase D (NAPE-PLD), fatty acid amide hydrolase (FAAH), diacylglycerol lipase (DAGL), monoacylglycerol lipase (MAGL) and cannabinoid receptors (CB1 and/or CB2) in lateral hypothalamus, paraventricular nucleus of the hypothalamus, liver, visceral adipose tissue (VAT), adrenal and thyroid. NIC offspring from both sexes did not show differences in hypothalamic ECS markers. Peripheral ECS markers showed no alterations in NIC males. In contrast, NIC females had lower liver DAGL and CB1, higher VAT DAGL, higher adrenal NAPE-PLD and higher thyroid FAAH. Endocannabinoids biosynthesis was affected by nicotine exposure during breastfeeding only in females; alterations in peripheral tissues suggest lower action in liver and higher action in VAT, adrenal and thyroid. Effects of nicotine exposure during lactation on ECS markers are sex- and tissue-dependent. This characterization helps understanding the phenotype of the adult offspring in this model and may contribute to the development of new pharmacological targets for the treatment of several metabolic diseases that originate during development.

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Section: Introductionmentioning

confidence: 98%

Nicotine exposure during breastfeeding alters the expression of endocannabinoid system biomarkers in female but not in male offspring at adulthood

Miranda

Rodrigues

Peixoto

et al. 2023

J Dev Orig Health Dis

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“…One of the two subjects with the lowest cotinine level was a child aged 6 to 12 months, and for four subjects where cotinine was detected alone, these levels were low. Present-day studies provide subjects with low levels of cotinine not associated with nicotine [ 30 ]. (iii) An older woman from the end of the 18th century was the only subject with a level of nicotine associated with the highest cotinine level; she died with anthracosis pigments associated with emphysema.…”

Section: Discussionmentioning

confidence: 99%

At the Origins of Tobacco-Smoking and Tea Consumption in a Virgin Population (Yakutia, 1650–1900 A.D.): Comparison of Pharmacological, Histological, Economic and Cultural Data

Macé¹,

Richeval

Alcouffe

et al. 2021

Biology

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(1) Background: The way tobacco and tea spread among virgin populations is of major interest our understanding of how ancient economic and cultural practices could have influenced current habits. (2) Methods: hair concentrations of theobromine, theophylline, caffeine, nicotine, and cotinine were measured in hair samples from 47 frozen bodies of people from eastern Siberia, dated from the contact with Europeans to the assimilation of people into Russian society. (3) Results: hair concentration of theobromine, theophylline, and caffeine vary with the type of beverage consumed: green, black, or local herbal teas. Shortly after the first contacts, a few heavy consumers of tobacco were found among light or passive consumers. Tobacco-related co-morbidities began to be recorded one century after and heavy tea users were only found from the 19th century (4) Conclusions: Economic factors and social and family contacts seem to have played a decisive role in tobacco consumption very early on. Behavioral evolution governed the process of substance integration into Siberian culture and was a determinant for the continuity of its use across long periods of time. Analyzing the respective contributions of social and economic processes in the use of these substances opens avenues of investigation for today’s public health.

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“…NNAL has a longer half-life but is not present in nicotine replacement products or e-cigarettes making it less useful for those products 11 . Several studies have reported correlations between the hair nicotine levels of mother-infant dyads exposed to secondhand smoke, which was able to reflect a longer duration of exposure (over a period of several months) compared to the other biomarkers [12][13][14][15] . Toenail nicotine levels were also reported to capture the longer term overall burden of tobacco smoke exposure in adults 5,16 , while newborn nails have been demonstrated to reflect drug exposure to substances such as caffeine, nicotine, cocaine, benzoylecgonine, morphine, and methadone, during pregnancy 17 .…”

Section: Introductionmentioning

confidence: 99%

Hair and nail nicotine levels of mothers and their infants as valid biomarkers of exposure to intrauterine tobacco smoke

Go¹,

Al-Delaimy²,

Schilling³

et al. 2021

Tob. Induc. Dis.

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Using nicotine in scalp hair to assess maternal passive exposure to tobacco smoke

Cited by 13 publications

References 31 publications

Nicotine exposure during breastfeeding alters the expression of endocannabinoid system biomarkers in female but not in male offspring at adulthood

Nicotine exposure during breastfeeding alters the expression of endocannabinoid system biomarkers in female but not in male offspring at adulthood

At the Origins of Tobacco-Smoking and Tea Consumption in a Virgin Population (Yakutia, 1650–1900 A.D.): Comparison of Pharmacological, Histological, Economic and Cultural Data

Hair and nail nicotine levels of mothers and their infants as valid biomarkers of exposure to intrauterine tobacco smoke

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