Using magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: tracers, hardware, and future medical applications

Chandrasekharan, Prashant; Tay, Zhi Wei; Hensley, Daniel; Zhou, Xinyi; Fung, K. L. Barry; Colson, Caylin; Lu, Yao; Fellows, Benjamin D.; Huynh, Quincy; Saayujya, Chinmoy; Yu, Elaine; Orendorff, Ryan; Zheng, Bo; Goodwill, Patrick; Rinaldi, Carlos; Conolly, Steven M.

doi:10.7150/thno.40858

Cited by 136 publications

(110 citation statements)

References 114 publications

Supporting

Mentioning

109

Contrasting

Order By: Relevance

“…MHT is a technique used to convert magnetic energy into heat using magnetic nanoparticles, such as Fe 3 O 4 , administering of alternating magnetic fields (AMF). [ 126 ] Unlike the widely explored PTT using light for heat generation to kill the tumor, the MHT can deal with deep tumors in various tissues because of the excellent tissue penetration ability of AMF. [ 127 ] Nevertheless, it has been shown that MHT alone cannot obtain a satisfactory therapeutic effect and thus is often used as a coadjutant in combination with other treatments in oncological therapy.…”

Section: Sonodynamic Therapy Combined With Other Treatmentsmentioning

confidence: 99%

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

et al. 2020

View full text Add to dashboard Cite

Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such as deeper penetration depth, absence of phototoxicity, and fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks to the facile engineering nature of nanotechnology, numerous novel nanoplatforms are being applied in this emerging field to tackle these intrinsic barriers and achieve continuous innovations. In particular, the combination of SDT with other treatment strategies has demonstrated a superior efficacy in improving anticancer activity relative to that of monotherapies alone. Therefore, it is necessary to summarize the nanomaterial-assisted combinational sonodynamic cancer therapy applications. Herein, the design principles in achieving synergistic therapeutic effects based on nanomaterial engineering methods are highlighted. The ultimate goals are to stimulate the design of better-quality combined sonodynamic treatment schemes and provide innovative ideas for the perspectives of SDT in promoting its future transformation to clinical application.

show abstract

Section: Sonodynamic Therapy Combined With Other Treatmentsmentioning

confidence: 99%

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

et al. 2020

View full text Add to dashboard Cite

show abstract

“…[60] Importantly, MPI as a new imaging modality with near-infinite contrast and linearly quantifiable signal compared with MRI has demonstrated a significant role when used in combination with SPIONs. [61] The concept of MPI is to exploit the intrinsic saturation property of SPIONs to create images. In other words, compared with MRI and other imaging modalities, MPI is free from the background signals of tissues.…”

Section: Immunoimaging With Mnpsmentioning

confidence: 99%

Section: Magnetic Dds Loaded With Immunomodulatory Agentsmentioning

confidence: 99%

Advances in Magnetic Nanoparticle‐Mediated Cancer Immune‐Theranostics

Cheng

Tsao

Chiang

et al. 2020

Adv Healthcare Materials

View full text Add to dashboard Cite

Cancer immunotherapy is a cutting‐edge strategy that eliminates cancer cells by amplifying the host's immune system. However, the low response rate and risks of inducing systemic toxicity have raised uncertainty in the treatment. Magnetic nanoparticles (MNPs) as a versatile theranostic tool can be used to target delivery of multiple immunotherapeutics and monitor cell/tissue responses. These capabilities enable the real‐time characterization of the factors that contribute to immunoactivity so that future treatments can be optimized. The magnetic properties of MNPs further allow the implementation of magnetic navigation and magnetic hyperthermia for boosting the efficacy of immunotherapy. The multimodal approach opens an avenue to induce robust immune responses, minimize safety issues, and monitor immune activities simultaneously. Thus, the object of this review is to provide an overview of the burgeoning fields and to highlight novel technologies for next‐generation immunotherapy. The review further correlates the properties of MNPs with the latest treatment strategies to explore the crosstalk between magnetic nanomaterials and the immune system. This comprehensive review of MNP‐derived immunotherapy covers the obstacles and opportunities for future development and clinical translation.

show abstract

“…[ 21 ] In the past decades, MHT has achieved promising clinical results in the treatment of brain cancer, prostate cancer, and esophageal cancer. [ 22 ] In general, compared with traditional therapies, the nanomaterial‐based PTT and MHT mediated by external stimuli displays tremendous advantages, such as noninvasiveness, spatiotemporal controllability, good targeting property, and reduced toxicity to normal tissues. [ 23 ]…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

et al. 2020

View full text Add to dashboard Cite

Figure 3. a) Schematic illustration of the PTT-assisted immunotherapy. b) PD-L1 expression on 4T1 tumor cells after different treatments. c) Flow cytometric examination of the intratumor infiltration of CD4 + and CD8 + T cells. d,e) The primary and distal tumor growth curves of 4T1 tumor-bearing mice. f) Quantification of pulmonary metastasis nodules in different groups of 4T1 tumor-bearing mice. g) The tumor growth curves of B16F10-bearing mice model (*p < 0.05, **p < 0.01, ***p < 0.001). Reproduced with permission. [52] Copyright 2019, Nature Research.

show abstract

Using magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: tracers, hardware, and future medical applications

Cited by 136 publications

References 114 publications

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Advances in Magnetic Nanoparticle‐Mediated Cancer Immune‐Theranostics

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Contact Info

Product

Resources

About