Advances in Magnetic Nanoparticle‐Mediated Cancer Immune‐Theranostics

Cheng, Hung Wei; Tsao, Hsin Yi; Chiang, Chih Sheng; Chen, San Yuan

doi:10.1002/adhm.202001451

Cited by 67 publications

(47 citation statements)

References 156 publications

(90 reference statements)

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“…The anti-cancer effects of MHT, such as DNA damage, Fenton reaction, and mechanical shear force, can lead to tumor cell necrosis and apoptosis 9 - 11 . Importantly, magnetic hyperthermia has a variety of effects on the tumor immune microenvironment 12 - 14 . These treatment strategies not only directly act on the cancer cells but also carry out immune effects on dendritic cell (DC) activation and T cell infiltration and thus elicit anticancer immunity.…”

Section: Introductionmentioning

confidence: 99%

Magnetism-mediated targeting hyperthermia-immunotherapy in “cold” tumor with CSF1R inhibitor

Fang

et al. 2021

Theranostics

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Background: Immunotherapy has profoundly changed the landscape of cancer management and represented the most significant breakthrough. Yet, it is a formidable challenge that the majority of cancers - the so-called “cold” tumors - poorly respond to immunotherapy. To find a general immunoregulatory modality that can be applied to a broad spectrum of cancers is an urgent need. Methods: Magnetic hyperthermia (MHT) possesses promise in cancer therapy. We develop a safe and effective therapeutic strategy by using magnetism-mediated targeting MHT-immunotherapy in “cold” colon cancer. A magnetic liposomal system modified with cell-penetrating TAT peptide was developed for targeted delivery of a CSF1R inhibitor (BLZ945), which can block the CSF1-CSF1R pathway and reduce M2 macrophages. The targeted delivery strategy is characterized by its magnetic navigation and TAT-promoting intratumoral penetration. Results: The liposomes (termed TAT-BLZmlips) can induce ICD and cause excessive CRT exposure on the cell surface, which transmits an “eat-me” signal to DCs to elicit immunity. The combination of MHT and BLZ945 can repolarize M2 macrophages in the tumor microenvironment to relieve immunosuppression, normalize the tumor blood vessels, and promote T-lymphocyte infiltration. The antitumor effector CD8 + T cells were increased after treatment. Conclusion: This work demonstrated that TAT-BLZmlips with magnetic navigation and MHT can remodel tumor microenvironment and activate immune responses and memory, thus inhibiting tumor growth and recurrence.

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Section: Introductionmentioning

confidence: 99%

Magnetism-mediated targeting hyperthermia-immunotherapy in “cold” tumor with CSF1R inhibitor

Fang

et al. 2021

Theranostics

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“…Superparamagnetic iron oxide nanoparticles possess characteristic magnetic properties for bioimaging applications. Their coating with polysaccharides provide robust drug delivery materials with theranostic applications [111,112]. Furthermore, as an innovative method for achieving a controlled drug delivery and bioimaging applications, superparamagnetic iron oxide nanoparticles coated with hyaluronan (HA) (HA-FeO).…”

Section: Polysaccharide-based Contrast Agentmentioning

confidence: 99%

Current-status and applications of polysaccharides in drug delivery systems

Prasher

Sharma

Mehta

et al. 2021

Colloid and Interface Science Communications

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The polysaccharide-based advanced drug delivery system owing to their biocompatibility, ability to encapsulate the drug molecules in their interspaces, and ability to achieve a controlled release of the cargo drug molecules result in improved drug pharmacokinetics. The drug-loaded polysaccharides possess ability to evade the multidrug-resistant microbial efflux pumps by aggregation effect, whereas the drug loaded polysaccharidefabricated metal nanoparticles present an exceptional candidature for effectively transporting the drug molecules across the membrane barriers while enabling the theranostic applications at the same time. The biodegradability of polysaccharide based drug delivery systems ensure a sustained release of the encapsulated drug molecules, which minimizes the side effects caused by a burst release of the cargo therapeutics. These drug delivery systems proved highly beneficial for the NSAIDs that otherwise manifest ulcerogenic effect in the gastrointestinal tract. The large surface area of polysaccharides further provide a higher drug-loading capacity, which maintains the optimal concentration of the cargo drug at the target sites. The emerging applications of biodegradable polysaccharides in the designing of multicompartmental microspheres revolutionized tissue engineering, multi drug delivery, and cell culturing technologies. The present review deals with the current-status of polysaccharides as advanced drug delivery systems.

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“…Maintaining T cell activity after activating the immune response is also the key to obtaining antitumor immunity. Combining checkpoint inhibitors with hyperthermia to avoid immune escape has been confirmed to provide significantly improved antitumor immunity 117 . MHT can overcome poor penetration of PTT into deeper tumor tissues, and should be explored as an alternative for combined PTT and immunotherapy.…”

Section: Image-guided Ptt and Immunotherapymentioning

confidence: 99%

Tumor immunotherapy and multi-mode therapies mediated by medical imaging of nanoprobes

Yang¹,

Guan²,

Zhang³

2021

Theranostics

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Immunotherapy is an effective tumor treatment strategy that has several advantages over conventional methods such as surgery, radiotherapy and chemotherapy. Studies show that multifunctional nanoprobes can achieve multi-mode image-guided multiple tumor treatment modes. The tumor cells killed by chemotherapies or phototherapies release antigens that trigger an immune response and augment the effects of tumor immunotherapy. Thus, combining immunotherapy and multifunctional nanoprobes can achieve early cancer diagnosis and treatment. In this review, we have summarized the current research on the applications of multifunctional nanoprobes in image-guided immunotherapy. In addition, image-guided synergistic chemotherapy/photothermal therapy/photodynamic therapy and immunotherapy have also been discussed. Furthermore, the application potential and clinical prospects of multifunctional nanoprobes in combination with immunotherapy have been assessed.

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Advances in Magnetic Nanoparticle‐Mediated Cancer Immune‐Theranostics

Cited by 67 publications

References 156 publications

Magnetism-mediated targeting hyperthermia-immunotherapy in “cold” tumor with CSF1R inhibitor

Magnetism-mediated targeting hyperthermia-immunotherapy in “cold” tumor with CSF1R inhibitor

Current-status and applications of polysaccharides in drug delivery systems

Tumor immunotherapy and multi-mode therapies mediated by medical imaging of nanoprobes

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