Using LIPCOF (Lid-Parallel Conjunctival Fold) for Assessing the Degree of Dry Eye, It is Essential to Observe the Exact Position of That Specific Fold

Schirra, F.; Höh, H.; Kienecker, Christina; Ruprecht, Klaus W.

doi:10.1007/978-1-4615-5359-5_120

Cited by 21 publications

(12 citation statements)

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“…The following parameters were analyzed with regard to episodes of endothelial allograft rejection: age and gender of the recipient, atopic dermatitis (manifest or by history), dry eye symptoms, surgeon, graft diameter, post-mortem time and storage time of grafts, graft preservation method, and duration of postoperative epithelial defects. In patients with dry eye symptoms or signs, the diagnosis was confirmed by performing the Schirmer test (<5 mm/5 min) and assessing the presence of lid parallel conjunctival folds (LIPCOF ≥2) [32]. It was also determined whether tear deficiency had been present before the episode of allograft rejection or was first observed following the rejection episode.…”

Section: Methodsmentioning

confidence: 99%

Risk factors for corneal allograft rejection: intermediate results of a prospective normal-risk keratoplasty study

Küchle¹,

Cursiefen²,

Nguyen³

et al. 2002

Graefe's Arch Clin Exp Ophthalmol

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The incidence of episodes of corneal endothelial allograft rejection following normal-risk keratoplasty was 13.5% within the first two postoperative years. However, the frequency of irreversible immunologic graft failure (3 per thousand) was lower than reported in the literature. Patients should be regularly followed up for at least 18 months postoperatively. Patients with underlying atopic dermatitis or dry eyes should receive special ophthalmological care.

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Section: Methodsmentioning

confidence: 99%

Risk factors for corneal allograft rejection: intermediate results of a prospective normal-risk keratoplasty study

Küchle¹,

Cursiefen²,

Nguyen³

et al. 2002

Graefe's Arch Clin Exp Ophthalmol

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“…However, in this study, we classified LIPCOF using an optimised grading scale, 13,[17][18][19] rather than the 'LIPCOF score' published by Hö h et al, 16 which evaluated the height of the set of folds in comparison to the tear meniscus height. 16,69 Previous findings of our group suggested an improvement of the predictive ability of LIPCOF using a new classification, 13,17 where the LIPCOF score is not derived from the height of the folds, but from the number of lid-parallel conjunctival folds that accumulate one above the other. 17 This optimised LIPCOF score enhanced the evaluation of both temporal and nasal LIPCOF, but nasal LIPCOF performed better than temporal LIPCOF and even LIPCOF Sum.…”

Section: Discussionmentioning

confidence: 99%

The relationship between clinical signs and dry eye symptoms

Pult

Purslow

Murphy

2011

Eye

146

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Purpose To evaluate (i) the relationship between traditional and new clinical tests (lid-wiper epitheliopathy (LWE), lid-parallel conjunctival folds (LIPCOF)) and dry eye symptoms in non-contact lens wearers, and (ii) that a combination of these tests can improve predictive ability for the development of dry eye symptoms. Methods Tear meniscus height (TMH), non-invasive break-up time (NIBUT), ocular hyperaemia, LIPCOF, phenol red thread test (PRTT), corneal and conjunctival staining, and LWE grades were observed in a cohort of 47 healthy, non-lens wearers (male ¼ 17, female ¼ 30, median age ¼ 35 years, range ¼ 19-70). Symptoms were assessed using the Ocular Surface Disease Index (OSDI). Results LWE was significantly correlated to both temporal and nasal LIPCOF (0.537or o0.607, Po0.05). LIPCOF and LWE were significantly correlated to NIBUT and PRTT (r4À0.248, Po0.001). Significant correlations were found between NIBUT and TMH (r ¼ 0.461, P ¼ 0.001) and PRTT (r ¼ 0.640, Po0.001). OSDI scores were significant correlated to NIBUT, TMH, PRTT, LIPCOF, and LWE (r4|0.31|; Po0.05). Significant discriminators of OSDI þ /À were NIBUT (area under the receiver operative characteristic curve (AUC) ¼ 0.895), TMH (0.715), PRTT (0.781), LIPCOF (temporal/nasal/Sum 0.748/0.828/0.816), and LWE (0.749). Best predictive ability was achieved by combining NIBUT with nasal LIPCOF (AUC ¼ 0.944). Conclusions The individual tests NIBUT, TMH, PRTT, LIPCOF, and LWE were significantly, but moderately, related to OSDI scores. The strongest relationship appeared by combining NIBUT with nasal LIPCOF.

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“…LIPCOF have been described as a sub-type of conjunctivochalasis that might represent a mild stage. [35] This hypothesis may be supported by the finding that the cross-sectional area of LIPCOF tissue appeared to be much smaller than that of conjunctivochalasis, and that even after conjunctivochalasis treatment the remaining tissue is still commonly much larger than LIPCOF. [23] However, with an increasing LIPCOF grade, an increase in crosssectional TMA was found for the temporal location.…”

Section: Discussionmentioning

confidence: 93%

Influence of Conjunctival Folds on Calculated Tear Meniscus Volume Along the Lower Eyelid

et al. 2016

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-nc-nd/4.0/ 2 Purpose: When calculating tear meniscus volume (TMV), tear meniscus height (TMH), radius (TMR) and cross-sectional area (TMA) are mostly measured at the centre of the lower lid margin. Lid-parallel conjunctival folds (LIPCOF) are known to influence the tear meniscus regularity. The aim of this study was to analyse the influence of LIPCOF on TMA measured by optical coherence tomography (OCT) and consequently, the calculated tear meniscus volume (TMV).Methods: Using OCT (Cirrus-HD; Carl Zeiss Meditec, Jena, Germany), TMH, TMR and TMA of 42 subjects (13M, 29F; mean age 27.3 SD±8.4 years) were measured directly below the pupil centre, plus at temporal and nasal locations perpendicularly below the limbus, where LIPCOF was also evaluated and graded. TMV for the different locations was calculated. Correlations between LIPCOF and the tear meniscus parameters were analysed using the Spearman Rank-Order coefficients.Differences between tear meniscus parameters at the different locations were evaluated by the paired t-test.Results: Central TMV (5.30±1.42x10 -2 µl/mm) was significantly positively correlated to LIPCOFsum (2.4±1.2) (r=0.422; p<0.05). The calculated temporal TMV was greater by 0.53x10 -2 µl/mm compared to the central TMV (p=0.037), while there was no significant difference in tear volume between the other locations.

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Using LIPCOF (Lid-Parallel Conjunctival Fold) for Assessing the Degree of Dry Eye, It is Essential to Observe the Exact Position of That Specific Fold

Cited by 21 publications

References 0 publications

Risk factors for corneal allograft rejection: intermediate results of a prospective normal-risk keratoplasty study

Risk factors for corneal allograft rejection: intermediate results of a prospective normal-risk keratoplasty study

The relationship between clinical signs and dry eye symptoms

Influence of Conjunctival Folds on Calculated Tear Meniscus Volume Along the Lower Eyelid

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