Using fluoroform in trifluoromethylation reactions

Conversion of fluoroform to CHCl3 and AlClxF3−xvia its mechanochemical reaction with AlCl3

“…2 Thus, they are called "super pollutants" and "super greenhouse gases", and their production and emission are controlled by the Kigali Amendment to the Montreal Protocol. 3 HFC-23 is produced as a by-product of CHF 2 Cl or HCFC-22 4 at ca. 20 Gg per year.…”

Isotopologues of potassium 2,2,2-trifluoroethoxide for applications in positron emission tomography and beyond

“…Over the past decade, substantial advances have been made in trifluoromethylation methods 2 – 4 . Fluoroform (HCF 3 ) is a major industrial byproduct and now gains attention as an affordable and atom-efficient source of the trifluoromethyl group (CF 3 ) 5 , 6 . Strategies for installing a trifluoromethyl group from fluoroform deploy nucleophilic or metal-mediated conversions (Fig.…”

Copper(i)-free syntheses of [11C/18F]trifluoromethyl ketones from alkyl or aryl esters and [11C/18F]fluoroform

“…15 In addition, trifluoromethyl ketones (TFMKs) are very useful synthons for the syntheses of important classes of compounds, such as trifluoromethyl alcohols and amines, [15][16][17][18] lactones, [19][20][21] and heterocycles. 22 [ 11 C]Fluoroform is readily synthesized 23 and converted into reactive [ 11 C]CF 3 Cu(I), which has been utilized to produce [ 11 C]trifluoromethylarenes in high molar activities from aryl iodides, boronic acids, diazonium salts, 24,25 or diaryliodonium salts. 26 [ 11 C]Trifluoromethylstyrenes have also been produced from arylvinyliodonium salts.…”

“…[ 11 C]Fluoroform is readily synthesized 23 and converted into reactive [ 11 C]CF 3 Cu( i ), which has been utilized to produce [ 11 C]trifluoromethylarenes in high molar activities from aryl iodides, boronic acids, diazonium salts, 24,25 or diaryliodonium salts. 26 [ 11 C]Trifluoromethylstyrenes have also been produced from arylvinyliodonium salts.…”