Isotopologues of potassium 2,2,2-trifluoroethoxide for applications in positron emission tomography and beyond
Qunchao Zhao,
Sanjay Telu,
Susovan Jana
et al.
Abstract:The 2,2,2-trifluoroethoxy group increasingly features in drugs and potential tracers for biomedical imaging with positron emission tomography (PET). Herein, we describe a rapid and transition metal-free conversion of fluoroform with paraformaldehyde into highly reactive potassium 2,2,2-trifluoroethoxide (CF3CH2OK) and demonstrate robust applications of this synthon in one-pot, two-stage 2,2,2-trifluoroethoxylations of both aromatic and aliphatic precursors. Moreover, we show that these transformations translat… Show more
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