2010
DOI: 10.1021/jp100777u
|View full text |Cite
|
Sign up to set email alerts
|

Using Cyclodextrins to Encapsulate Oxygen-Centered and Carbon-Centered Radical Adducts: The Case of DMPO, PBN, and MNP Spin Traps

Abstract: We present electron spin resonance (ESR) experiments that describe the interaction of beta-cyclodextrin (beta-CD) with spin adducts of three spin traps: 5,5-dimethyl-1-pyrroline N-oxide (DMPO), N-tert-butyl-alpha-phenylnitrone (PBN), and 2-methyl-2-nitrosopropane (MNP). The focus was on spin adducts of oxygen-centered radicals trapped by DMPO and PBN and on carbon-centered radical adducts trapped by MNP. The radicals were generated by reaction with hydroxyl radicals and the spin adducts studied were DMPO/OH an… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

3
18
0

Year Published

2011
2011
2023
2023

Publication Types

Select...
4
1
1

Relationship

0
6

Authors

Journals

citations
Cited by 23 publications
(21 citation statements)
references
References 38 publications
3
18
0
Order By: Relevance
“…The upfield chemical shift indicates that the C(2)-H moiety is located close to the polar -OCH 3 groups of the CD portals and the downfield chemical shift indicates that the -CH 3 and C(3)-H moieties are encapsulated into the DM-b-CD cavity. Figure 2b depicts a plausible structure of the inclusion complex with DM-b-CD, which is in agreement with the optimized structure of the inclusion complex of native b-CD with DMPO-OH adduct using Gaussian 03 software [12].…”
Section: Resultssupporting
confidence: 77%
“…The upfield chemical shift indicates that the C(2)-H moiety is located close to the polar -OCH 3 groups of the CD portals and the downfield chemical shift indicates that the -CH 3 and C(3)-H moieties are encapsulated into the DM-b-CD cavity. Figure 2b depicts a plausible structure of the inclusion complex with DM-b-CD, which is in agreement with the optimized structure of the inclusion complex of native b-CD with DMPO-OH adduct using Gaussian 03 software [12].…”
Section: Resultssupporting
confidence: 77%
“…In the absence of CeNP (control), the time scans for the DMPO/ . OH adduct show a significant decrease with time, and a half-life (τ 1/2 ) of 960 s, which is similar to the reported value 48,58 . Surprisingly, in the presence of 2.5 mM and 1.5 mM free CeNP the relative intensity of the DMPO/ .…”
Section: Hydroxyl Radical Scavenging Activity Of Cenp and Nanoreactorssupporting
confidence: 87%
“…The characteristic DMPO/ . OH spin adduct has a half-life of around 15 min 57 , and its EPR spectrum consists of four lines with peak intensity ratios of 1:2:2:1 and hyperfine coupling constants a N and a H for 14 N and 1 H equal to 14.9 G (inset Figure 3A). Hydroxyl radicals were generated by a typical Fenton reaction involving Fe 2+ and H 2 O 2 , 42 and their scavenging activity by CeNP was estimated by analyzing the plots (time scans) for DMPO/ .…”
Section: Hydroxyl Radical Scavenging Activity Of Cenp and Nanoreactorsmentioning
confidence: 99%
See 1 more Smart Citation
“…β‐CD as the reducing agent provided an interesting test, as β‐CD is known to encapsulate the nitroso radical trap used in these systems . There is even evidence that β‐CD may lead to higher amounts of the active monomeric form of MNP, which exists in an equilibrium with inactive aggregates .…”
Section: Resultsmentioning
confidence: 99%