Characterization of inclusion complex of vitamin E compound with 2,6-di-O-methylated β-cyclodextrin as the solubility enhancer and its kinetic determination for radical scavenging ability

Sueishi, Yoshimi; Hori, Masashi; Inazumi, Naoya

doi:10.1007/s10847-011-0018-3

Cited by 16 publications

(8 citation statements)

References 17 publications

(26 reference statements)

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“…Vitamin E has a wide range of use as food supplements and in pharmaceuticals; however, its poor solubility is a drawback for its use and processing. Inclusion complexation with CD molecules enables to overcome this challenge and enhance the water solubility of Vitamin E compounds. − Here, to show the fast dissolution of Vitamin E/HPβCD-IC NF and to show the enhanced water-solubility of Vitamin E in Vitamin E/HPβCD-IC NF, a piece of Vitamin E/HPβCD-IC NF web sample (approximately 4 cm × 4 cm) and a drop of pure Vitamin E (at the similar amount presence in the nanofiber) put into separate Petri-dishes and water was poured onto the samples. As apparent from Figure and the Movie S1, Vitamin E/HPβCD-IC NF web was dissolved immediately in water, whereas pure Vitamin E remained in the Petri dishes without dissolving.…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, CDs have drawn interest to parry the limitations of Vitamin E by inclusion complexation. As reported in the literature, CD-IC of Vitamin E can be utilized to enhance the solubility and oxidation stability of this active agent. − Even in the related studies, which were performed by our group, CD-ICs of Vitamin E were incorporated into polymeric nanofibers such polylactic acid and polycaprolactone for potential applications in food packaging and wound healing, where we have achieved enhanced release and effective antioxidant profile along with the improved water-solubility and UV-light stability for Vitamin E.…”

Section: Introductionmentioning

confidence: 96%

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Antioxidant Vitamin E/Cyclodextrin Inclusion Complex Electrospun Nanofibers: Enhanced Water Solubility, Prolonged Shelf Life, and Photostability of Vitamin E

Çelebioğlu

Uyar

2017

J. Agric. Food Chem.

101

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Here, we demonstrated the electrospinning of polymer-free nanofibrous webs from inclusion complex (IC) between hydroxypropyl-β-cyclodextrin (HPβCD) and Vitamin E (Vitamin E/HPβCD-IC NF). The inclusion complexation between HPβCD and Vitamin E was prepared by using two different molar ratios (Vitamin E/HPβCD; 1:2 and 1:1), which correspond to theoretical value of ∼13% (w/w) and 26% (w/w) loading of Vitamin E in the nanofiber (NF) matrix. After electrospinning and storage, a very high loading of Vitamin E (up to ∼11% w/w, with respect to fiber matrix) was preserved in Vitamin E/HPβCD-IC NF. Because of the cyclodextrin inclusion complexation, only a minimal weight loss (only ∼2% w/w) was observed. While pure Vitamin E is insoluble in water, Vitamin E/HPβCD-IC NF web has displayed fast-dissolving behavior. Because of the greatly enhanced water-solubility of Vitamin E, Vitamin E/HPβCD-IC NF web has shown effective antioxidant activity. Additionally, Vitamin E/HPβCD-IC NF web has provided enhanced photostability for the sensitive Vitamin E by the inclusion complexation in which Vitamin E/HPβCD-IC NF still kept its antioxidant activity even after exposure to UV-light. Moreover, a 3 year-old Vitamin E/HPβCD-IC NF sample has shown very similar antioxidant efficiency when compared with freshly prepared Vitamin E/HPβCD-IC NF indicating that long-term stability was achieved for Vitamin E in the CD-IC fiber matrix. In brief, our results suggested that polymer-free electrospun Vitamin E/HPβCD-IC nanofibrous webs could have potential applications in food, pharmaceuticals, and healthcare thanks to its efficient antioxidant activity along with enhanced water-solubility, prolonged shelf life, and high photostability of Vitamin E.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Antioxidant Vitamin E/Cyclodextrin Inclusion Complex Electrospun Nanofibers: Enhanced Water Solubility, Prolonged Shelf Life, and Photostability of Vitamin E

Çelebioğlu

Uyar

2017

J. Agric. Food Chem.

101

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“…Recently, there has been a rising interest of using CDs in order to overcome limitations of antioxidants, antibacterials, drugs and provide advantages as mentioned above. The studies associated with IC of a-TC with CDs were reported in the literature as well to increase solubility [14,15] and improve oxidative stability of foods [16]. In addition to these studies, there are studies in which a-TC/CD-IC incorporated into polymeric films [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity and photostability of α-tocopherol/β-cyclodextrin inclusion complex encapsulated electrospun polycaprolactone nanofibers

Aytaç

Uyar

2016

European Polymer Journal

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Cyclodextrin inclusion complexes (CD-ICs) can be encapsulated into electrospun nanofibers in order to achieve delivery systems having high surface area and highly porous nanofibrous structures. In this study, a well-known antioxidant molecule, a-tocopherol (a-TC) (vitamin E) was chosen as an active agent for inclusion complexation with bcyclodextrin. Polycaprolactone (PCL) nanofibers encapsulating a-tocopherol/b-cyclodex trin inclusion complex (a-TC/b-CD-IC) which has high antioxidant activity and photostability was produced via electrospinning (PCL/a-TC/b-CD-IC-NF). The formation of a-TC/b-CD-IC was confirmed by XRD. Phase solubility studies showed A n-type complex formation between a-TC and b-CD. SEM revealed that bead-free nanofibers were successfully produced from PCL/a-TC/b-CD-IC system. PCL nanofibers encapsulating a-TC without CD-IC was also produced for comparison (PCL/a-TC-NF). Antioxidant test results showed that PCL/a-TC/b-CD-IC-NF had higher antioxidant activity as compared to PCL/a-TC-NF in methanol:water (1:1) system due to the stabilization and solubility increment of a-TC in the cavity of b-CD. PCL/a-TC/b-CD-IC-NF was more stable against UV-light when compared to PCL/a-TC-NF due to the presence of inclusion complexation. In brief, PCL/a-TC/b-CD-IC-NF with the advantages of having nanofibrous structure and encapsulating CD-ICs, may serve as a novel route for administration of a-TC due to its higher antioxidant activity and better UV-light stability.

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“…Vitamins are essential micro-nutrients that the human body requires for the proper functioning of its metabolism (Kamal-Eldin and Appelqvist, 1996; Suarra et al , 1993; Suzuki et al , 1993). Among various vitamins, vitamin E (VE), which is obtained from many fruits and vegetables, nuts and seeds, and seed oils, is a strong and effective free radical scavenger to protect the body cells and bio-macromolecules from the radical attacks (Sueishi et al , 2012; Koontz et al , 2009). Hence, VE possesses many advantages like anti-aging, prevention and treatment of cardiovascular diseases and anti-tumor effect.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity of vitamin E enhanced by cyclodextrin inclusion complex

Chen¹,

Liu²,

Zhou³

et al. 2021

BFJ

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PurposeThe study aims to find potential method to enhance the stability and antioxidant activity of vitamins.Design/methodology/approachVitamin E (VE) and β-cyclodextrin (CD) were used to prepare the VE-β-CD inclusion complex via a solution method. The yielded VE-β-CD obtained from optimal experimental conditions was characterized. The mechanism of complex formation and the properties of the complex was investigated by steady-state and time-resolved fluorescence techniques. The antioxidant activity of VE-β-CD was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and compared with pure VE.FindingsThree experimental factors – reaction temperature (T), molar ratio of VE to β-CD (rm) and inclusion time (t) – were studied for the preparation of VE-β-CD. At experimental conditions of T = 60°C, rm = 1:3 and t = 3 h, a maximum inclusion rate of VE (78.62%) was obtained. The Fourier-transform infrared spectroscopy (FTIR) shows that VE molecule was physically encapsulated by β-CD in the yielded product. Subsequentially, the steady-state fluorescence intensity of VE was found to increase upon encapsulation by β-CD due to the hindrance of fluorescence quenching of VE molecules inside the hydrophobic cavity of β-CD, and an inclusion constant K was determined to equal 3.58 × 103 L/mol from the fluorescence results. The fluorescent observation was confirmed by time-resolved fluorescence experiment as the lifetime of VE increased with an increase in β-CD concentration.Originality/valueThe ability of removing radicals by VE was significantly enhanced after the formation of inclusion complex with β-CD.

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Characterization of inclusion complex of vitamin E compound with 2,6-di-O-methylated β-cyclodextrin as the solubility enhancer and its kinetic determination for radical scavenging ability

Cited by 16 publications

References 17 publications

Antioxidant Vitamin E/Cyclodextrin Inclusion Complex Electrospun Nanofibers: Enhanced Water Solubility, Prolonged Shelf Life, and Photostability of Vitamin E

Antioxidant Vitamin E/Cyclodextrin Inclusion Complex Electrospun Nanofibers: Enhanced Water Solubility, Prolonged Shelf Life, and Photostability of Vitamin E

Antioxidant activity and photostability of α-tocopherol/β-cyclodextrin inclusion complex encapsulated electrospun polycaprolactone nanofibers

Antioxidant activity of vitamin E enhanced by cyclodextrin inclusion complex

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