Uselessness of Topical Calcipotriol as Monotherapy for Acrodermatitis Continua of Hallopeau

Kokelj, F; Plozzer, Carmela; Trevisan, Giusto

doi:10.1080/00015550152384416

Cited by 7 publications

(3 citation statements)

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“…However, case studies about the efficiency of calcipotriol in the treatment of ACH have been completely controversial. Piraccini et al[ 16] found 9 of their 15 patients with ACH of the nail responding to topical calcipotriol, whereas Kokelj et al[ 7] reported on 7 patients with ACH resistant to calcipotriol and presumed that monotherapy with this agent might be useless. In our patient, the topical treatment with calcipotriol has been effective, but did not lead to clearance of all inflammatory signs, with persisting pain and erythema.…”

Section: Discussionmentioning

confidence: 99%

“…There is still no established treatment regime for ACH since various treatment modalities (topical and systemic treatments, table 1) showed different individual efficiency. Topical treatments with corticosteroids, tar, dithranol, fluorouracil, calcipotriol and tacrolimus were reported as therapeutic options [3,4,5,6,7,8]. In some refractory ACH patients even systemic therapy with retinoids, corticosteroids or different other immunosuppressing and immunomodulating drugs, colchicine, dapsone, sulphasalazine, retinoids, tetracycline, PUVA, methotrexate, cyclosporin A and infliximab did not always lead to total clearance of clinical symptoms [3,4,5,9,10,11,12,13,14].…”

Section: Introductionmentioning

confidence: 99%

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Successful Treatment of Acrodermatitis Continua of Hallopeau with Sequential Combination of Calcipotriol and Tacrolimus Ointments

Brill¹,

Elshorst-Schmidt²,

Valesky³

et al. 2005

Dermatology

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Acrodermatitis continua of Hallopeau (ACH) is a rare type of pustular psoriasis affecting the digits. We report on a 43-year-old female patient who had been suffering from ACH for more than 20 years. Despite the fact that the disease was localized on one finger during the whole period, several topical and systemic treatments resulted in only temporary or partial improvement of the lesion. Although the monotherapies with calcipotriol and tacrolimus ointments gave no satisfying results in the long-term management of the disease, the combination of both agents led to a continuous improvement of the patient’s skin condition.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Successful Treatment of Acrodermatitis Continua of Hallopeau with Sequential Combination of Calcipotriol and Tacrolimus Ointments

Brill¹,

Elshorst-Schmidt²,

Valesky³

et al. 2005

Dermatology

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“…Topical treatment is usually ineffective, even though there have been occasional reports on the beneficial effect of 5-fluorouracil [1] and topical calcipotriol [2,3,4], especially in combination with acitretin [5], tacrolimus [6,7] or in a fixed combination with betamethasone dipropionate [8]; betamethasone valerate has been reported to be effective under occlusion and in combination with oral tetracyclines [9]. Topical 8-methoxypsoralen has also been reported to be effective in association with both UVA [10] and narrow-band UVB [11].…”

Section: Discussionmentioning

confidence: 99%

Treatment of Acrodermatitis Continua of Hallopeau with TNF-Blocking Agents: Case Report and Review

et al. 2010

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Acrodermatitis continua of Hallopeau (ACH) is a rare acropustular eruption, characterized by sterile pustules, paronychia and atrophic skin changes, onychodystrophy and osteolysis of the distal phalanges of the fingers and toes. It is considered to be a variant of pustular psoriasis with a chronic relapsing course and frequent refractoriness to many therapeutic modalities, which can be amenable to successful treatment by tumor necrosis factor α antagonists. We report 1 patient with pustular psoriasis and ACH whom we have treated successfully with etanercept (for 30 months) and then adalimumab (for 13 months and ongoing). Blanching was initially achieved with etanercept 50 mg twice a week, but suppression of periungual inflammation then required combination therapy with etanercept 50 mg twice a week and methotrexate 10 mg weekly; lower doses of both drugs did not allow complete control of the disease. Eventually, adalimumab 40 mg every 2 weeks has provided the most cost-effective response in this patient, allowing maintenance of response with partial nail regrowth under monotherapy.

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Dermatological Disorders

Piraccini

Holzberg

Pasch

et al. 2018

Baran &Amp; Dawber's Diseases of the Nails and Their Management

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Uselessness of Topical Calcipotriol as Monotherapy for Acrodermatitis Continua of Hallopeau

Cited by 7 publications

References 0 publications

Successful Treatment of Acrodermatitis Continua of Hallopeau with Sequential Combination of Calcipotriol and Tacrolimus Ointments

Successful Treatment of Acrodermatitis Continua of Hallopeau with Sequential Combination of Calcipotriol and Tacrolimus Ointments

Treatment of Acrodermatitis Continua of Hallopeau with TNF-Blocking Agents: Case Report and Review

Dermatological Disorders

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