Usefulness of the histamine intolerance assessment questionnaire for diagnosis

Mayo‐Yáñez, Miguel; Díaz-Díaz, Andrea; Calvo‐Henríquez, Christian; Chiesa‐Estomba, Carlos Miguel; Figueroa, Angélica; Martín-Martín, Carlos

doi:10.1016/j.reval.2020.10.002

Cited by 5 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, the presence of dermatological symptoms was not associated with a deficit in DAO activity, although the presence of both entities simultaneously does not seem to be so clear, being found only in small subgroups in the literature [ 11 , 12 , 28 ]. The low specificity and complex variability of symptoms undoubtedly contribute to the current difficulty in creating associations between symptoms and DAO deficit, as well as achieving consensus on the diagnostic criteria for histamine intolerance [ 6 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…Other limitations would be the cross-sectional design without a control group, the lack of other determinations (IgE, histamine, allergens), the lack of follow-up, or the lack of repeated DAO activity levels in the same patient [ 37 , 38 ]. The strengths are the measurement of the NPIF and to relate it for the first time with DAO activity and histamine intolerance in AR, but even the analysis of DAO activity has been called into question as a diagnostic method for histamine intolerance [ 10 , 25 , 29 , 30 , 39 ]. This study opens up a range of possibilities, but the degree of the relationship found might not be enough to define the real link between DAO activity and AR severity.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between allergic rhinitis and diamine oxidase activity: A preliminary report

Mayo‐Yáñez¹,

Díaz-Díaz²,

Vázquez-Barro³

et al. 2021

ALS

View full text Add to dashboard Cite

Aim: To analyze the diamine oxidase (DAO), the main catabolic enzyme of histamine, degradation activity and its relation with symptoms of persistent allergic rhinitis. Methods: In this descriptive and analytical observational study, we collected DAO activity levels and the nasal peak inspiratory flow. Results: Enzymatic activity deficit in 108 patients was 46.3% (95% CI, 0.44 – 0.63), 33.33% in mild and 47.92% in moderate/severe rhinitis (p = 0.376). The nasal peak inspiratory flow in patients with a deficit in DAO activity was 76.30 ± 28.40 L/min compared to 93.62 ± 37.50 L/min in patients with normal enzymatic activity (p = 0.010). Conclusions: It seems that the lower the catabolic activity of DAO, the lower the nasal peak inspiratory flow observed. Although DAO activity levels could be a severity biomarker in allergic rhinitis, a cause-effect association cannot be concluded. The enzyme could be another actor in the pathophysiology of allergic rhinitis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relationship between allergic rhinitis and diamine oxidase activity: A preliminary report

Mayo‐Yáñez¹,

Díaz-Díaz²,

Vázquez-Barro³

et al. 2021

ALS

View full text Add to dashboard Cite

show abstract

“…Several diagnostic strategies involving various tests have been proposed, because direct HIT-specific diagnostic criteria are lacking. Following the recommendations of the clinical guidelines, only cases matching the analytical criteria and presenting a compatible clinical history (history of flushing, itching, diarrhea, nausea/vomiting, abdominal pain, dyspnea, rhinitis, dysphonia, dizziness, low blood pressure, or tachycardia) were classified as DAO deficiency [ 20 , 21 , 32 , 33 , 34 ]. It was necessary to analyze the symptoms with reference to their temporal onset for the differential diagnosis, because adverse food reactions are only suspected in the case of a temporal relationship (min <4 h) to food intake.…”

Section: Methodsmentioning

confidence: 99%

Diamine Oxidase Activity Deficit and Idiopathic Rhinitis: A New Subgroup of Non-Allergic Rhinitis?

Mayo‐Yáñez

Díaz-Díaz

Calvo-Henríquez

et al. 2023

Life

Self Cite

View full text Add to dashboard Cite

Idiopathic rhinitis represents more than 50% of non-allergic rhinitis, a heterogeneous group that involves the symptomatic inflammation of the nasal mucosa. The TRPV1 receptor of unmyelinated C-type neurons appears to be involved in its pathophysiology. Histamine, whose main catabolic enzyme is DAO, is one of the mediators that can activate this receptor. The failure of DAO causes an increase in the level of histamine in the body and, consequently, the activation of TRPV1. The objective was to investigate the existence of a DAO enzyme activity deficit in idiopathic rhinitis and its correlation with symptoms. A cross-sectional study was conducted in 116 idiopathic rhinitis patients, and DAO activity, nasal peak inspiratory flow, and rhinitis severity were recorded. The prevalence of a DAO activity deficit was 41.38% (95%CI 0.33–0.50; p = 0.05). The DAO activity in patients with mild rhinitis was 52.93 ± 8.72 HDU/mL, in those with moderate rhinitis it was 120.33 ± 71.63 HDU/mL, and in those with severe rhinitis it was 92.58 ± 27.75 HDU/mL (p = 0.006). The NPIF in patients with a DAO activity deficit was 107.92 ± 34.05 L/min, compared to 72.35 ± 27.16 L/min in patients with normal enzymatic activity (p < 0.001), demonstrating a linear correlation between activity levels and nasal obstruction (−0.45; p < 0.001). Therefore, patients with a DAO deficiency and idiopathic rhinitis could present a milder disease course, because the repeated and continuous activation of TRPV1 led to a partial or total decrease in their response (desensitization). This new theory represents a different perspective for the study of idiopathic rhinitis and its relationship with TRPV1, with the regulation or modulation of the desensitization of TRPV1 being an important therapeutic target for patients with idiopathic rhinitis in the future.

show abstract

“…Concerns have been raised regarding fact that HIT suspected patients often receive questionnaires from non-scientific sources and after filling them out they come to the specialist already convinced of their diagnosis and accordingly refuse further examination. Questionnaires from non-scientific sources are not considered to be a reliable diagnostic approach [ 70 ].…”

Section: Diagnostic Approachesmentioning

confidence: 99%

Histamine Intolerance—The More We Know the Less We Know. A Review

et al. 2021

View full text Add to dashboard Cite

The intake of food may be an initiator of adverse reactions. Food intolerance is an abnormal non-immunological response of the organism to the ingestion of food or its components in a dosage normally tolerated. Despite the fact that food intolerance is spread throughout the world, its diagnosing is still difficult. Histamine intolerance (HIT) is the term for that type of food intolerance which includes a set of undesirable reactions as a result of accumulated or ingested histamine. Manifestations may be caused by various pathophysiological mechanisms or a combination of them. The problem with a “diagnosis” of HIT is precisely the inconstancy and variety of the manifestations in the same individual following similar stimuli. The diagnosing of HIT therefore requires a complex time-demanding multidisciplinary approach, including the systematic elimination of disorders with a similar manifestation of symptoms. Among therapeutic approaches, the gold standard is a low-histamine diet. A good response to such a diet is considered to be confirmation of HIT. Alongside the dietary measures, DAO supplementation supporting the degradation of ingested histamine may be considered as subsidiary treatment for individuals with intestinal DAO deficiency. If antihistamines are indicated, the treatment should be conscious and time-limited, while 2nd or 3rd generation of H1 antihistamines should take precedence.

show abstract

Usefulness of the histamine intolerance assessment questionnaire for diagnosis

Cited by 5 publications

References 25 publications

Relationship between allergic rhinitis and diamine oxidase activity: A preliminary report

Relationship between allergic rhinitis and diamine oxidase activity: A preliminary report

Diamine Oxidase Activity Deficit and Idiopathic Rhinitis: A New Subgroup of Non-Allergic Rhinitis?

Histamine Intolerance—The More We Know the Less We Know. A Review

Contact Info

Product

Resources

About