Usefulness of the forced oscillation technique in assessing the therapeutic result of tracheobronchial central airway obstruction

Matsumura, Yasuo; Kitaguchi, Yoshiaki; Kinota, Fumiya; Kosaka, Makoto; Urushihata, Kazuhisa; Ushiki, Atsuhito; Yamamoto, Hiroshi; Kawakami, Satoshi; Hanaoka, Masayuki

doi:10.1016/j.resinv.2018.01.005

Cited by 5 publications

(7 citation statements)

References 18 publications

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“…6 Recently, our previous study revealed that patients with CAO exhibited relatively high values of R5 and R20, Fres, and ALX, and a negative reactance at 5 Hz. 8 In the present study, we first demonstrated the similarities and differences between CAO and COPD, in terms of FOT and PFT parameters. These groups were analyzed with the FOT and PFTs in parallel at one respiratory institute.…”

Section: Discussionsupporting

confidence: 51%

“…In that study, airway resistance was measured in patients with CAO; the FOT was applied with the MostGraph-01 (Chest Co., Ltd., Tokyo, Japan) before and after interventional bronchoscopy. 8 We found that the resistance measured at 20 Hz (R20) with the FOT was significantly correlated with the amount of airway dilation achieved with interventional bronchoscopy. 8 To date, no study has directly compared FOT measurements between patients with CAO and those with peripheral airway obstruction, such as COPD.…”

Section: Introductionmentioning

confidence: 78%

“…8 We found that the resistance measured at 20 Hz (R20) with the FOT was significantly correlated with the amount of airway dilation achieved with interventional bronchoscopy. 8 To date, no study has directly compared FOT measurements between patients with CAO and those with peripheral airway obstruction, such as COPD. In the current study, we applied the FOT to evaluate airway resistance in patients with CAO prior to interventional bronchoscopy and treatment-naïve patients with COPD.…”

Section: Introductionmentioning

confidence: 78%

“…In patients with CAO, our previous study revealed that an alteration in the R20 was a useful parameter in estimating airway dilation in CAO after interventional bronchoscopy. 8 Thus, the R20 appeared to be the optimal parameter for evaluating mechanical changes in CAO. On the other hand, in patients with COPD, our group previously found that the R20 was weakly correlated with airway reversibility.…”

Section: Discussionmentioning

confidence: 98%

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Differences Between Central Airway Obstruction and Chronic Obstructive Pulmonary Disease Detected with the Forced Oscillation Technique

Matsumura

Kitaguchi

Tokoro

et al. 2020

COPD

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Background: Obstructive ventilatory disturbances occur in both chronic obstructive pulmonary disease (COPD), a typical disease representative of peripheral airway obstruction, and central airway obstruction (CAO). Pulmonary function tests (PFTs), which depend on patient effort, are traditionally used to evaluate lung function. The forced oscillation technique (FOT) is an effort-independent method for examining lung function during tidal breathing. The FOT is used universally to assess respiratory function in patients with COPD. Several studies have measured FOT to assess ventilatory disturbances in CAO. The results showed that FOT measurements in patients with CAO were similar to those reported in patients with COPD. However, no studies have compared FOT measurements directly between CAO and COPD. The aim of this study was to identify differences in ventilatory disturbances between peripheral and central airway obstructions in COPD and CAO, before patients received pharmacological therapy or bronchoscopic interventions, respectively. Patients and Methods: We retrospectively included 16 patients with CAO (10 cases of tracheal obstruction and 6 cases of bronchial obstruction) and 75 treatment-naïve patients with COPD (60 cases in Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage II and 15 cases in GOLD stage III) that were admitted from December 2013 to May 2017. Prior to treatment, patients were examined with the FOT and PFTs. Results: All parameters measured with the FOT in the inspiratory phase were significantly worse in patients with CAO than in patients with COPD. The PFTs showed that the CAO group had a significantly lower peak expiratory flow rate. In the airway wall thickening phenotype of COPD, a difference between the inspiratory and expiratory phases of the resonance frequency (ΔFres) was the best indicator for distinguishing between peripheral and central airway obstructions. Conclusion:This study compared differences between CAO and COPD (mainly GOLD stage II). We found that the FOT measurement, ΔFres, was the optimal indicator of the difference between the airway wall thickening COPD phenotype and CAO. Thus, the difference might be due to mechanical changes that occur in COPD with airway wall thickening.

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Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 98%

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Differences Between Central Airway Obstruction and Chronic Obstructive Pulmonary Disease Detected with the Forced Oscillation Technique

Matsumura

Kitaguchi

Tokoro

et al. 2020

COPD

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“…Another study concluded that the therapeutic results can also be estimated in the case of patients with central airway obstruction using the oscillometric parameter Rrs20. 82 …”

Section: Clinical Applicationsmentioning

confidence: 99%

Lung Function Assessment by Impulse Oscillometry in Adults

Porojan-Suppini¹,

Fira-Mlădinescu²,

Marc³

et al. 2020

TCRM

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Over the past decades, impulse oscillometry (IOS) has gained ground in the battery of pulmonary function tests. Performing the test requires minimal cooperation of the patient; therefore, it is a useful tool, especially in evaluating lung mechanics in children, elderly patients, and those who cannot perform spirometry. Oscillometry has also been used in both clinical and research departments. Studies were published mainly in asthma regarding detection of bronchodilator response and the therapeutic response to different drugs. Furthermore, it has been shown to be a sensitive technique to evaluate disease control. Other studied diseases were COPD, interstitial lung diseases, small airway disease, impairment of lung function due to exposure to occupational hazards or smoking, central airways obstruction, cystic fibrosis, monitoring lung mechanics during mechanical ventilation and sleep, neuromuscular diseases, lung transplant, and graft function. The aim of this review is to present the utility of oscillometry on the previously mentioned clinical fields.

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Is R5-R20 a marker of small airway function?

Shirai

2018

Respiratory Investigation

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Usefulness of the forced oscillation technique in assessing the therapeutic result of tracheobronchial central airway obstruction

Abstract: The FOT is suitable and convenient for assessing therapeutic results in patients with tracheobronchial CAO. The alteration of R20 is useful for estimating the airway dilation of CAO after interventional bronchoscopy.

Cited by 5 publications

References 18 publications

<p>Differences Between Central Airway Obstruction and Chronic Obstructive Pulmonary Disease Detected with the Forced Oscillation Technique</p>

<p>Differences Between Central Airway Obstruction and Chronic Obstructive Pulmonary Disease Detected with the Forced Oscillation Technique</p>

<p>Lung Function Assessment by Impulse Oscillometry in Adults</p>

Is R5-R20 a marker of small airway function?

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