Is R5-R20 a marker of small airway function?

Shirai, Toshihiro

doi:10.1016/j.resinv.2018.02.003

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…Asthma treatment may differ slightly depending on the particle size and the site of the inflammation, according to certain research. ( Shirai, 2018 ) On the other hand, there is disagreement on the appropriate ICS particle sizes to utilize for CVA therapy.…”

Section: Introductionmentioning

confidence: 99%

Patient response to the management during the acute presentation of cough variant Asthma: Retrospective cohort study

Ibrahim Arif,

Amer,

Adnan Alkamal

et al. 2023

Saudi Journal of Biological Sciences

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Section: Introductionmentioning

confidence: 99%

Patient response to the management during the acute presentation of cough variant Asthma: Retrospective cohort study

Ibrahim Arif,

Amer,

Adnan Alkamal

et al. 2023

Saudi Journal of Biological Sciences

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“…Conversely, the resistance of the respiratory system at 20 Hz (R20) is considered indicative of only the central airway, while the difference between R5 and R20 (R5–R20) is considered indicative of only the peripheral airway. Some studies have reported that the interpretation of the difference (R5–R20) between respiratory resistance (Rrs) values at 5 and 20 Hz remains debatable [14]. However, in this study, we analyzed by dividing participants into three groups with R20 and R5–R20 values, described above, to elucidate the discussion points.…”

Section: Introductionmentioning

confidence: 99%

Comparison of therapeutic effects of inhaled corticosteroids on three subtypes of cough variant asthma as classified by the impulse oscillometry system

et al. 2019

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Background Cough variant asthma (CVA) is one of the most common causes of chronic persistent cough, and early treatment with inhaled corticosteroids (ICSs) is recommended to attenuate the inflammation and remodeling. The impulse oscillometry system (IOS) is a novel device for respiratory functional assessment that has not yet been assessed in terms of CVA. Therefore, we investigated the relationship between CVA and IOS, and the difference in therapeutic effects of ICSs among the subtype classifications by IOS. Methods The following ICSs were randomly prescribed in daily medical care: coarse-particle ICS (fluticasone propionate [FP]), fine-particle ICS (mometasone furoate [MF]), and moderate-particle ICS (budesonide [BUD]). Treatment effects were assessed by the Leicester cough questionnaire (LCQ) and were compared among three separated subtypes based on IOS measurements: central, peripheral, and resistless. Results Regarding LCQ scores, in the central type, the LCQ of the MF group was significantly lower than FP and BUD. In the peripheral type, the LCQ of the FP group was significantly lower than MF and BUD. In the resistless type, the LCQ of the MF group was significantly lower than BUD. Also, IOS factors were improved by 4 weeks of therapy with ICS. Thus, there was strong relationship between subtypes and particle size in terms of effectiveness. Conclusions There is a strong relationship between IOS subtype classification and ICS particle size in terms of therapeutic efficiency in CVA. It appears important to determine the ICS particle size, based on the IOS subtype classification, before treatment. Electronic supplementary material The online version of this article (10.1186/s12931-019-1005-2) contains supplementary material, which is available to authorized users.

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