Usefulness of the delta neutrophil index to predict 30-day mortality in patients with ST segment elevation myocardial infarction

Kong, Taeyoung; You, Je Sung; Park, In-Cheol

doi:10.1016/j.resuscitation.2017.08.114

Cited by 3 publications

(6 citation statements)

References 22 publications

(31 reference statements)

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“…Mobilisation of neutrophils occurs rapidly after AMI in mice and humans (1, 3, 4) and their number in peripheral blood correlates with the extent of myocardial injury (1-3) . The bone marrow has been regarded as the principal source for neutrophils that are mobilised to peripheral blood after injury, because (i) it is the primary site for granulopoiesis (8-10) ; (ii) it contains ample reserves of mature cells and; (iii) releases neutrophils in response to injection of exogenous chemokines (12-16) .…”

Section: Discussionmentioning

confidence: 99%

“…Acute myocardial infarction (AMI) is a substantial sterile injury that leads to a rapid increase in peripheral blood neutrophils (1-5) . Elevated peripheral blood neutrophil number post-AMI correlates with the extent of myocardial injury, degree of cardiac dysfunction, and mortality (1-3) . Defective neutrophil removal enhances susceptibility to cardiac rupture (6) and inhibition of neutrophil recruitment in AMI reduces infarct size (1) , but antibody depletion of neutrophils prior to AMI increases infarct size, enhances fibrosis and lowers the number of M2 macrophages in the healing myocardium (1, 7) .…”

Section: Introductionmentioning

confidence: 99%

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Endothelial Cell-Derived Extracellular Vesicles Elicit Neutrophil Deployment From the Spleen Following Acute Myocardial Infarction

Akbar

Braithwaite

Corr

et al. 2020

Preprint

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Acute myocardial infarction rapidly increases blood neutrophils (<2 hours). Release of neutrophils from bone marrow, in response to chemokine elevation, has been considered their source, but chemokine levels peak up to 24 hours after injury, and after neutrophil elevation. This suggests that additional non chemokine-dependent processes may be involved. Endothelial cell (EC) activation promotes the rapid (<30 minutes) release of extracellular vesicles (EVs), which are enriched in vascular cell adhesion molecule-1 (VCAM-1) and miRNA-126, and are thus a potential mechanism for communicating with remote tissues. Here, we show that injury to the myocardium rapidly mobilises neutrophils from the spleen to peripheral blood and induces their transcriptional activation prior to their arrival at injured tissue. Ischemic myocardium leads to the generation and release of EC-derived-EVs bearing VCAM-1. EC-EV delivery to the spleen alters inflammatory gene and chemokine protein expression, and mobilises neutrophils to peripheral blood. Using CRISPR/Cas9 genome editing we generated VCAM-1-deficient EV and showed that its deletion removed the ability of EC-EV to provoke the mobilisation of neutrophils. Furthermore, inhibition of miRNA-126 in vivo reduced myocardial infarction size in a mouse model. Our findings show a novel mechanism for the rapid mobilisation of neutrophils to peripheral blood from a splenic reserve, independent of classical chemokine signalling, and establish a proof of concept for functional manipulation of EV-communications through genetic alteration of parent cells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Endothelial Cell-Derived Extracellular Vesicles Elicit Neutrophil Deployment From the Spleen Following Acute Myocardial Infarction

Akbar

Braithwaite

Corr

et al. 2020

Preprint

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“…In 2008, Nahm et al [13] reported for the first that DNI was implicated in identifying disease severity in patients with sepsis, Subsequently, several studies have reported on the usefulness of DNI for various infectious diseases such as pneumonia, urinary tract infection, and liver abscess [25–27] . It has also recently been found that DNI is associated with disease severity or prognosis in noninfectious, inflammation-related diseases such as vasculitis, myocardial infarction, pulmonary embolism, AKI, and cardiac arrest [28–32] . A study on the usefulness of DNI in predicting the incidence of multiorgan dysfunction syndrome (MODS) and mortality in trauma patients was also reported [33] .…”

Section: Discussionmentioning

confidence: 99%

Usefulness of delta neutrophil index as a biomarker to predict postoperative complication in patients who underwent esophagectomy

2021

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Esophagectomy demonstrates a high incidence of complications owing to its complexity and invasiveness; hence, early detection of complications is important. We aimed to evaluate the predictive value of the delta neutrophil index (DNI) for complications after esophagectomy. We retrospectively analyzed patients who underwent esophagectomy in the department of general surgery at a single institution between January 2011 and October 2020. Patient characteristics, laboratory findings, and clinical outcomes were assessed. Fifty-seven patients were enrolled in this study, of whom 31 (54.4%) had complications. The complication group had significantly longer mean mechanical ventilation, hospital stay and intensive care unit stay periods, and higher acute physiology, age, chronic health evaluation score and mortality rate than the noncomplication group. DNI on postoperative day (POD) 2 was also significantly higher in the complication group. Logistic regression analysis showed that DNI on POD 2 was an independent risk factor associated with the complications. Receiver operating characteristic curve analysis showed that the area under curve of DNI on POD 2 was 0.712 (cutoff value: 2.15%, sensitivity 61.5%, and specificity 70.8%). Our study indicated that postoperative DNI can be useful as an early predictive biomarker of the complications after esophagectomy.

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“…The results were presented as odds ratios (ORs) and 95% con dential intervals (CIs) [15]. The net reclassi cation improvement (NRI) and integrated discrimination improvement (IDI) values were measured to verify how the addition of the TMA score improved the prediction model for clinical outcomes [21]. To determine the statistical signi cance of the IDI and NRI indices, we resampled 1,000 times using a standard bootstrap method [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…The net reclassi cation improvement (NRI) and integrated discrimination improvement (IDI) values were measured to verify how the addition of the TMA score improved the prediction model for clinical outcomes [21]. To determine the statistical signi cance of the IDI and NRI indices, we resampled 1,000 times using a standard bootstrap method [21,22]. The 30-day survival was plotted using Kaplan-Meier curves and compared using log-rank test [19].…”

Section: Discussionmentioning

confidence: 99%

Thrombotic Microangiopathy Score as a New Predictor for Neurologic Outcome in Patients Undergoing Targeted Temperature Management After Out-of-hospital Cardiac Arrest

Kong

Lee

Jeon

et al. 2020

Preprint

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Abstract Background: Given the morphological characteristics of schistocytes, thrombotic microangiopathy (TMA) score can be beneficial as it can be quickly and serially measured without additional effort or costs. This study aimed to investigate whether the serial TMA scores until 48 h post admission are associated with clinical outcomes in patients undergoing targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA). Methods:We retrospectively evaluated a cohort of 185 patients using a prospective registry. We analyzed the TMA score at admission and after 12, 24, and 48 hours. The primary outcome measures were poor neurologic outcome at discharge and 30-day mortality. Results:Increased TMA scores at all measured time points were independent predictors of poor neurologic outcomes and 30-day mortality, with the TMA score at time-12 showing the strongest correlation (OR, 3.008; 95% CI, 1.707–5.3; p=0.001 and HR, 1.517; 95% CI, 1.196–1.925; p=0.001.Specifically, TMA score ≥2 at time-12 was closely associated with increased predictability of poor neurologic outcome (OR, 6.302; 95% CI: 2.841–13.976; p<0.001) and 30-day mortality (HR, 2.656; 95% CI: 1.675–4.211; p<0.001).Conclusions: Increased TMA scores predicted the neurologic outcome and 30-day mortalityin patients undergoing TTM after OHCA. In addition to the benefit of being quickly and serially measured by using an automated hematology analyzer without additional effort or costs, this finding indicates that the TMA score may be a helpful tool for rapid risk stratification and identification of the need for intensive care in patients with ROSC after OHCA.

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Usefulness of the delta neutrophil index to predict 30-day mortality in patients with ST segment elevation myocardial infarction

Cited by 3 publications

References 22 publications

Endothelial Cell-Derived Extracellular Vesicles Elicit Neutrophil Deployment From the Spleen Following Acute Myocardial Infarction

Endothelial Cell-Derived Extracellular Vesicles Elicit Neutrophil Deployment From the Spleen Following Acute Myocardial Infarction

Usefulness of delta neutrophil index as a biomarker to predict postoperative complication in patients who underwent esophagectomy

Thrombotic Microangiopathy Score as a New Predictor for Neurologic Outcome in Patients Undergoing Targeted Temperature Management After Out-of-hospital Cardiac Arrest

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