Usefulness of serum Wisteria floribunda agglutinin‐positive Mac‐2 binding protein in children with primary sclerosing cholangitis

Abstract

Serum WFA -M2BP levels are useful to identify patients with advanced liver histology in pediatric PSC.

Mac‐2 binding protein glycan isomer as noninvasive tool to assess liver fibrosis in children with chronic liver disease

“…This comes in line with Yeh et al 23 24 Moreover, several studies confirmed a positive correlation between M2GBPI and liver function test (ALT and total bilirubin), and a negative correlation with albumin. 18,[25][26][27] Furthermore, positive correlation of serum WFA þ -M2BPGI was reported with AST, ALT and alpha fetoprotein while a negative correlation was found with platelet counts in HBV-related HCC patients. 28 We found that serum M2BPGI along with AST, total bilirubin, PELD, histological activity index and APRI were predictors of fibrosis in CLD patients.…”

“…Moreover, several studies confirmed a positive correlation between M2GBPI and liver function test (ALT and total bilirubin), and a negative correlation with albumin 18 ,. 25–27 Furthermore, positive correlation of serum WFA + ‐M2BPGI was reported with AST, ALT and alpha fetoprotein while a negative correlation was found with platelet counts in HBV‐related HCC patients 28 …”

Functional glycomics: Application to medical science and hepatology

“…In the clinic, a high‐sensitivity chemiluminescence enzyme immunoassay can be used to measure serum M2BPGi . M2BPGi can be used as a liver fibrosis biomarker not only for chronic hepatitis C, but also for other chronic liver diseases, such as chronic hepatitis B, non‐alcoholic fatty liver disease, autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis (Table ). The predictive abilities of M2BPGi levels in serum for these chronic liver diseases are relatively lower than that for chronic hepatitis C. It is known that Mac‐2bp serum levels increase with acute liver injury and decrease after recovery, suggesting that certain mechanisms underlie the increase of serum M2BPGi levels, especially in chronic hepatitis C, and these should be further investigated.…”

Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein evaluates liver function and predicts prognosis in liver cirrhosis

“…developed a glycan‐based immunoassay, FastLec‐Hepa, to simply and accurately measure serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein (WFA + ‐M2BP) which is a specific glycosylation isomer of M2BP with GalNAc residue or the clustered LacNAc (Gal‐GlcNAc) structure in chronic hepatitis C (CHC) patients, and found that it increased with advanced fibrosis and could be used to assess patient's response to anti‐viral therapy. Since then, accumulated evidence has indicated the usefulness of WFA + ‐M2BP as a novel and non‐invasive marker for the assessment of liver fibrosis in CHC, chronic hepatitis B (CHB), NAFLD, non‐alcoholic steatohepatitis (NASH), autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). Moreover, WFA + ‐M2BP has also been validated to predict the development of hepatocellular carcinoma (HCC) in CHC and CHB patients.…”