Mac‐2 binding protein glycan isomer as noninvasive tool to assess liver fibrosis in children with chronic liver disease

Behairy, Ola Galal; Elgendy, S.A.; Ibrahim, Dalia; Mansour, Amira I.; El-Shimi, O.S.

doi:10.1111/hepr.13608

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…The previous studies on serum biomarkers including APRI, FIB-4, and FibroTest have shown that they are useful for selecting pediatric patients with liver cirrhosis who should undergo a liver biopsy (21)(22)(23)(24). However, chronic hepatitis C generally progresses slowly during childhood with no cases showing liver cirrhosis in our subjects, consistent with reports in previous studies (25,26).…”

Section: Discussionsupporting

confidence: 89%

The role of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in the assessment of fibrosis in children with chronic hepatitis C

Tajiri

Suzuki

Bessho

et al. 2021

Preprint

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BackgroundAt present non-invasive fibrosis markers are not available for assessment of liver fibrosis in children with chronic hepatitis C. MethodsSixty-three children with chronic hepatitis C were included. Changes in Wisteria floribunda agglutinin-positive Mac-2 binding protein (M2BPGi) levels were evaluated in l3 of 27 treatment-naive patients during the observation period of the natural course of disease (median 4, range 3-6 years). Changes during treatment were evaluated in 27 of 36 patients for 4 (2-9) years of post-treatment follow-up. ResultsThere were significant differences in the levels of M2BPGi between the control group and HCV F0 group (P=0.002) and between the control group and HCV F1 group (P<0.001). Receiver operating characteristic curve analysis showed that to detect stage F1 fibrosis cut off value was 0.95 for M2BPGi with sensitivity 52%, specificity 90%, and area under the curve 0.687. A substantial decrease in M2BPGi levels by treatment was shown from 0.98±0.57 at pre-treatment to 0.42±0.15 at post-treatment (P<0.001) in the 27 treated-patients. ConclusionsOur study shows new findings that M2BPGi may be useful to predict the presence of a mild degree of fibrosis in children with chronic hepatitis C and such a mild fibrosis may be quickly resolved by antiviral therapies.

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Section: Discussionsupporting

confidence: 89%

The role of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in the assessment of fibrosis in children with chronic hepatitis C

Tajiri

Suzuki

Bessho

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…Regarding adults, there are various articles evaluating the diagnostic capability of patients with NAFLD ( 36 – 39 ). However, regarding children, there are only articles evaluating biliary atresia or multiple diseases together ( 40 – 43 ). It is of great significance that we evaluated the diagnostic capability of M2BPGi for assessing the advanced fibrosis status in pediatric patients with NAFLD for the first time.…”

Section: Discussionmentioning

confidence: 99%

Stratification by Non-invasive Biomarkers of Non-alcoholic Fatty Liver Disease in Children

et al. 2022

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BackgroundThe spectrum of non-alcoholic fatty liver disease (NAFLD) ranges from isolated hepatic steatosis to non-alcoholic steatohepatitis to fibrosis. We aimed to introduce useful biomarkers released during liver inflammation and fibrogenesis that are easy to use in outpatient clinic and adjust to children to evaluate each NAFLD stage without biopsy.MethodsThis prospective study included 60 patients aged under 19 years whose alanine aminotransferase (ALT) levels were elevated from March 2021. All patients were proven to have NAFLD by ultrasonography and laboratory work-up to exclude other causes of hepatitis. Fibroscan and additional laboratory tests for biomarkers [procollagen type1 amino-terminal propeptide (P1NP), osteocalcin, interleukin-6 (IL-6), and Mac-2 binding protein glycosylated isomer (M2BPGi)] were performed. Fibroscan-AST (FAST) score was used for the comparison of steatohepatitis and liver stiffness measurement (kPa) was used for the comparison of advanced fibrosis.ResultsThe biomarker that showed a significant difference between the FAST-positive and negative groups was the P1NP/osteocalcin ratio with a p-value of 0.008. The area under receiver operating characteristic (AUROC) of P1NP/osteocalcin ratio*ALT values (values obtained through multivariate analysis) was 0.939 with the cut-off value of 305.38. The biomarkers that showed a significant difference between the LSM-positive and negative groups were IL-6 and M2BPGi with a p-values of 0.005 and <0.001. AUROC of IL-6 *AST values (values obtained through multivariate analysis) was 0.821 with the cut-off value of 228.15. M2BPGi showed a significant linear relationship with LSM in Pearson correlation analysis (Pearson correlation coefficient = 0.382; p = 0.003). The diagnostic capability of M2BPGi to evaluate advanced fibrosis showed an acceptable result (AUROC = 0.742; p = 0.022).ConclusionsNon-invasive biomarkers can be used to predict each stage of NAFLD in children. The measurements of P1NP, IL-6 or M2BPGi along with the basic chemistry tests would help determine the stage of NAFLD they correspond to at the time of initial diagnosis and predict responsiveness after the treatment.

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“…Previous studies on serum biomarkers, including APRI, FIB-4, and FibroTest, have shown that they are useful for selecting pediatric patients with liver cirrhosis who should undergo a liver biopsy 21 – 24 . However, chronic hepatitis C generally progresses slowly during childhood, with no cases showing liver cirrhosis in our subjects, consistent with reports in previous studies 25 , 26 .…”

Section: Discussionmentioning

confidence: 99%

The role of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in the assessment of fibrosis in children with chronic hepatitis C

Tajiri

Suzuki

Bessho

et al. 2022

Sci Rep

View full text Add to dashboard Cite

At present, noninvasive fibrosis markers are not available for the assessment of liver fibrosis in children with chronic hepatitis C. Sixty-three children with chronic hepatitis C were included. Changes in Wisteria floribunda agglutinin-positive Mac-2 binding protein (M2BPGi) levels were evaluated in l3 of 27 treatment-naive patients during the natural course of disease (median 4, range 3–6 years). Changes during treatment were evaluated in 27 of 36 patients for 4 (2–9) years of posttreatment follow-up. There were significant differences in the levels of M2BPGi between control group and HCV F0 group (P = 0.002) and between control group and HCV F1 group (P < 0.001). Receiver operating characteristic curve analysis showed that to discriminate stage F1 fibrosis from F0, the cut-off value was 0.95 for M2BPGi with a sensitivity of 52%, specificity of 90%, and area under the curve of 0.687. A substantial decrease in M2BPGi levels by treatment was shown from 0.98 ± 0.57 at pretreatment to 0.42 ± 0.15 at posttreatment (P < 0.001) in the 27 treated patients. Our study shows new findings that M2BPGi may be useful to predict the presence of a mild degree of fibrosis in children with chronic hepatitis C, and such mild fibrosis may be quickly resolved by treatment.

show abstract

Mac‐2 binding protein glycan isomer as noninvasive tool to assess liver fibrosis in children with chronic liver disease

Cited by 5 publications

References 27 publications

The role of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in the assessment of fibrosis in children with chronic hepatitis C

The role of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in the assessment of fibrosis in children with chronic hepatitis C

Stratification by Non-invasive Biomarkers of Non-alcoholic Fatty Liver Disease in Children

The role of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in the assessment of fibrosis in children with chronic hepatitis C

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